Protein Alignment dnc and pde3a

DIOPT Version :10

• Sequence 1: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Sequence 2: XP_009298269.1
• Gene: pde3a / 567051
• ZFINID: ZDB-GENE-041210-23
• Length: 1124
• Species: Danio rerio
• Alignment Length: 887
• Identity: 218/887 - (24%)
• Similarity: 338/887 - (38%)
• Gaps: 238/887 - (26%)

  Fly   488 QLLPTSKMQAEQGSIGDLQKYHSRYLKNRRHTLANVRFDV-ENGQGARSPLEGGSPSAGLVLQNL 551
            :|||.......:||.||:..:     |.||.:.:.|..|: ::||         |.|......:|
Zfish   197 RLLPEQGASHREGSRGDIPVF-----KRRRRSSSVVSSDMAQHGQ---------SRSKSHRRTSL 247

  Fly   552 P-QRRESFLYRSDSDFEMSPKSMSRNSSIASERFKEQEASILVD-----RSHG--EDLI----VT 604
            | .:||..|.:.:.|    .|..:|.|...|...:....|:.||     .:||  .||:    :.
Zfish   248 PCLQREQMLPQQEWD----NKRGARGSQQPSGLMQSSGTSVTVDIAVMGEAHGLISDLLADQSLA 308

  Fly   605 PFAQILASLRSVRNNLLS--LTNVP------------------ASNKSRRPNQ------------ 637
            |  .|.::||:| :|||:  ||..|                  .|:....|.:
Zfish   309 P--NICSTLRAV-SNLLNTQLTFQPLHHRPRLGPLLAFSDGHTCSDSEEAPEKGERLAIPKRLRR 370

  Fly   638 --------------SSSASRSGNP---PGAPLSQGEEAYTRLATD-----TIEELDWCLDQLETI 680
                          :::.|.:|.|   || |:.:...|..:...|     .:....|....:.:|
Zfish   371 SLHPGLLRRISSTWTTTTSATGLPTLEPG-PVRRDRSASIKAPHDGPSSSLVNSDSWNNSNMLSI 434

  Fly   681 QTHRSVSDMASLKFKRMLNKELSHFSESSR--SGNQISEYICSTFLDKQQEFDL-------PSLR 736
            ...||:    |..:....|.....:|:|.|  |.:.||...........|...|       ||:.
Zfish   435 SKSRSM----SASYAASSNTTNHIYSKSRRGCSSSTISPLASPCHSPPVQSSPLTSPTNKTPSVE 495

  Fly   737 VEDNPELVAA----NAAAGQQSAGQYARSRSPRGPPMSQISGVKRPLS---HTNSFT-------- 786
            :.| |||...    .|....|||...:.:..|  ||....|...||.|   |::..|
Zfish   496 LPD-PELPPPRSPHKALTHSQSAPSSSAALWP--PPTPLCSSCGRPYSKQRHSDGSTEPAERTQQ 557

  Fly   787 ---------------------------------GERLPTFGVETPRENE------------LGTL 806
                                             ..|..|.....|.|.:            |..|
Zfish   558 SDEPAMMSSDYDSTYETNHSDSSDFAQTDEDREARRTLTLATLIPAEEKPILAPEPLLMEGLEPL 622

  Fly   807 LGELDTWGIQIFSIGEFSVNRPLTCV----AYTIFQSRELLTSLMIPPKTFLNFMSTLEDHYVKD 867
            |.:::.|...|||:.| ..|....|:    :|.:|....|..:..||.:.|:|:...||:.| :|
Zfish   623 LCQINNWNFPIFSLVE-KTNGRCGCILSQMSYRLFVDTGLFETFKIPVREFMNYFHALENGY-RD 685

  Fly   868 NPFHNSLHAADVTQSTNVLLNTP----------------------------------------AL 892
            .|:||.:||.||..:...|...|                                        .|
Zfish   686 IPYHNRIHATDVLHAVWYLTTQPVPGLPTLRTLGSSDSDSGLAHGRMKYLMSRTNAVEEEGYGCL 750

  Fly   893 EGVFTPLEVGGALFAACIHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNQ-G 956
            .|:...||:.....||.:||.||||.||.|||.:|:..|::|||.|||||||.|.|:.|..:: .
Zfish   751 SGLIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAASAWNLFMSRPE 815

  Fly   957 CDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMVETKKVAGSGVLLLD--NYTDRIQ 1019
            .:...::...:.:..|.:||:.:|:||:.||...||:...     ||...|...:|  |..||:.
Zfish   816 YNFLASLDHMEFKRFRFLVIEAILATDLKKHFDFLAEFNA-----KVGDDGCSGIDWTNENDRLL 875

  Fly  1020 VLENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKERESGMDISPMCDRHNATIEKSQVGFI 1084
            |.:..:..||::.|.|...|:.:|...::.||:.|||:|...|:.|||..||....:.|.|..||
Zfish   876 VCQMCIKLADINGPLKCKDLHLQWTEGIVNEFYEQGDEESSLGLPISPFMDRSAPQLAKLQESFI 940

  Fly  1085 DYIVHPLWETWADL-------VHP---DAQDILD-TLEENRDYYQSMIPPSPPPSGVDENP---Q 1135
            .:||.||..::...       |||   |..::.| :.||:.|..:.....:...|.:.:.|   :
Zfish   941 THIVGPLCSSYDSAALMPGRWVHPLPKDGDEVEDESEEEDEDTAEEEEEDASTSSELSQKPAPKK 1005

  Fly  1136 EDRIRFQVT---LEESD--QENLAELEEGDESGGESTTTGTT 1172
            ..::..|::   ||..:  ::.:||..:....|.|||...||
Zfish  1006 RRKVFCQISHHLLENHEMWKKVIAEESQSQTEGEESTCLSTT 1047

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDE4_UCR	603..725	CDD:465648	33/177 (19%)
		PDEase_I	870..1110	CDD:459723	89/293 (30%)
pde3a	XP_009298269.1	PDEase_I	688..947	CDD:459723	82/263 (31%)