Protein Alignment dnc and pde4d

DIOPT Version :10

• Sequence 1: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Sequence 2: XP_068079221.1
• Gene: pde4d / 566998
• ZFINID: ZDB-GENE-081105-16
• Length: 806
• Species: Danio rerio
• Alignment Length: 799
• Identity: 420/799 - (52%)
• Similarity: 527/799 - (65%)
• Gaps: 128/799 - (16%)

  Fly   451 GGTATTTQNSSSVS--VAAHHRLTSSSASALATSHPSNSQLLPTSKMQAEQGSIGDLQKYHSRYL 513
            |...||..:..:|:  .|..|.....:..:|...:...|:    ...:..|....|.:||.:...
Zfish     4 GNEVTTLVSPGNVTDGNAPKHLWRQQNPVSLQIQNSLGSR----KNYRVRQRGFSDTEKYLNPRT 64

  Fly   514 KNRRHTLAN--------------------VRFDVENG-QGARSPLEG-GSPSAGLVLQ-NL--PQ 553
            .:|.:.:..                    .||||:|| ...||||:. .||.:||:|| |.  .|
Zfish    65 MDRTYAVDTGTRPGLKKSRMSWPSSFQGLKRFDVDNGTSSGRSPLDPMASPGSGLILQANFVHSQ 129

  Fly   554 RRESFLYRSDSDFEMSPKSMSRNSSIASERFKEQEASILVDRSHGEDLIVTPFAQILASLRSVRN 618
            ||||||||||||:::|||||||||||||:             .||:|:|||||||:|||||:|||
Zfish   130 RRESFLYRSDSDYDLSPKSMSRNSSIASD-------------IHGDDMIVTPFAQVLASLRTVRN 181

  Fly   619 NLLSLTNV--PASNKSRRPNQSSSASRSGNPPGAPLSQ--------------------------- 654
            |..:||||  ..||..|.|        ..|||  |:::
Zfish   182 NFAALTNVQQERSNNKRSP--------MCNPP--PITKTSYTVLEVQTLKSKSTDAQLHKTQTKQ 236

  Fly   655 ----GEEAYTRLATDTIEELDWCLDQLETIQTHRSVSDMASLKFKRMLNKELSHFSESSRSGNQI 715
                .||||.:|||:|:||||||||||||:||..|||:|||.|||||||:||:|.||.||||||:
Zfish   237 ANGDSEEAYQKLATETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQV 301

  Fly   716 SEYICSTFLDKQQEFDLPSLRVEDNPELVAANAAAGQQSAGQYARSRSPRGPPMSQISGVKRPLS 780
            ||||.|||||||.|.::||                     .|..:.:..:..|||||||||: |:
Zfish   302 SEYISSTFLDKQNEVEMPS---------------------PQSQKDKEKKKRPMSQISGVKK-LT 344

  Fly   781 HTNSFTGERLPTFGVETPRENELGTLLGELDTWGIQIFSIGEFSVNRPLTCVAYTIFQSRELLTS 845
            |::|.|...:|.|||:|..|:||...|.:::.||:.:|.:.|||.|||||.:.|||||.|:||.:
Zfish   345 HSSSLTNSNIPRFGVKTETEDELAKELEDVNKWGLNVFKVSEFSGNRPLTVMMYTIFQERDLLKT 409

  Fly   846 LMIPPKTFLNFMSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACI 910
            ..||..||:.::.||||||..|..:||::|||||||||:|||:|||||.|||.||:..|:||:.|
Zfish   410 FKIPLDTFITYLMTLEDHYHADVAYHNNIHAADVTQSTHVLLSTPALEAVFTDLEILAAIFASAI 474

  Fly   911 HDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMV 975
            |||||||::||||:|::|||||||||.||||||||||.|||||.:.||||.|:.|||||:|||||
Zfish   475 HDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMV 539

  Fly   976 IDIVLSTDMSKHMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLY 1040
            |||||:|||||||:||||||||||||||..|||||||||:||||||:|:|||||||||||||.||
Zfish   540 IDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLY 604

  Fly  1041 KRWVALLMEEFFLQGDKERESGMDISPMCDRHNATIEKSQVGFIDYIVHPLWETWADLVHPDAQD 1105
            ::|...:|||||.|||:|||.||:||||||:|||::|||||||||||||||||||||||||||||
Zfish   605 RQWTDRIMEEFFSQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQD 669

  Fly  1106 ILDTLEENRDYYQSMIPPSPPPSGVDENPQ------EDRIRFQVTLE---ESD---------QEN 1152
            ||||||:||::|||.||.||.|: :|.:.:      :::.:|::|||   |||         :|:
Zfish   670 ILDTLEDNREWYQSTIPQSPSPA-LDTSSEGRRAAGQEKFQFELTLEEDGESDTEKDSGSPPEED 733

  Fly  1153 LAELEEGDESGGESTTTGT 1171
            ..|.||.:.|..:|.|..|
Zfish   734 EEEEEEEENSCSDSKTLCT 752

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDE4_UCR	603..725	CDD:465648	80/154 (52%)
		PDEase_I	870..1110	CDD:459723	191/239 (80%)
pde4d	XP_068079221.1	PDE4_UCR	166..311	CDD:465648	80/154 (52%)
		PDEase_I	434..674	CDD:459723	191/239 (80%)