Protein Alignment dnc and pde3b

DIOPT Version :10

• Sequence 1: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Sequence 2: XP_691883.5
• Gene: pde3b / 563432
• ZFINID: ZDB-GENE-160728-20
• Length: 1103
• Species: Danio rerio
• Alignment Length: 957
• Identity: 242/957 - (25%)
• Similarity: 363/957 - (37%)
• Gaps: 284/957 - (29%)

  Fly   343 TSLKEHQP-LPPPITIATGYCGSCESV--HHSSATSSSAGTVP----------PGGQQTQEYIAG 394
            |||....| |.|.:....|..||..::  .|......|||.||          |..:.:...:..
Zfish   212 TSLGCLSPSLRPVLACVAGVSGSLLALCFDHYYPPRESAGRVPNAEEKVPVIRPRRRSSCVSLGE 276

  Fly   395 TSSTPSPRIKLKFRKPHKSCWSR--IVL---------AP--IGSAGGSSSATTVIGSNSN---ET 443
            ||::.....|:. |:|...|.||  ::|         .|  .|:..|:....:||....|   |.
Zfish   277 TSTSYYGSCKMP-RRPSLPCISREQMILWDWDLKQWYKPQYQGAVSGNGVDLSVINEARNLVSEL 340

  Fly   444 LASSSTTGGTATTTQNSSSVSVAAHHRLTSSSASALATSHPSN--SQLLPTSKMQAEQGSIGDLQ 506
            |...|.:....::.::.||:       :.:.|.|.....:|..  ....|.::|
Zfish   341 LMDPSLSPHALSSLRSVSSL-------MGAFSGSCRPRVNPFTPFPGFYPCAEM----------- 387

  Fly   507 KYHSRYLKNRRHTLANVRFDVENGQGARSPLEGGSPSAGLVLQNLPQRRESFLYRSDSDFEMSPK 571
                               |..:.:|.|.|::|.|....|   ..||.|.|
Zfish   388 -------------------DDPSERGERKPVKGLSSRNSL---PTPQLRRS-------------- 416

  Fly   572 SMSRNSSI-----ASERFKEQEASILVDRSHGEDLIVTPFAQILASLRS--VRNNLLSLTNVPAS 629
              |.:||:     ||.|::.....    |||.|          |:|..|  ..:|||::....:|
Zfish   417 --SASSSLPPLDPASSRWERTNGK----RSHSE----------LSSFVSNGPNSNLLTIPKQRSS 465

  Fly   630 N--------KSRRPNQSSS----ASRSGNPPGAPLSQGEEAYTRLATDTIEELDWCLDQLETIQT 682
            :        .||||..|.|    .|.|.:||..|   |....||...:..:..|:.        |
Zfish   466 SVTLSYGHTLSRRPGASPSLSPVTSPSHSPPAGP---GSSLVTRSPVEFPDTADFL--------T 519

  Fly   683 HRSVSDMASLKFKRMLNKELSH------FSESSRSGNQISEYICSTFLDKQQEFDLPSLRVEDN- 740
            ..||:          |:|.|.:      |.:..|:  ..|..:| |...:|....:||:.|.:.
Zfish   520 KPSVN----------LHKPLGYTMSSPDFQQQYRT--SASTPLC-TSCGRQMLKGVPSVEVVEGH 571

  Fly   741 ----PELVAANAAAGQQSAGQ--------YARSRSPRGPPMSQISGVK-----RPLSHTNSFTGE 788
                .|:....:|.|.:..|:        .|.|:..|   .|..:|.|     .....|:|....
Zfish   572 HTTANEMQRTRSADGAEYGGENLIREESLEAESQEER---TSDTAGEKVNSQPEEEEQTSSTEQS 633

  Fly   789 RLPTFGVETPR------ENELGTLLGELDTWGIQIFSIGEFS---VNRPLTCVAYTIFQSRELLT 844
            .|...|.|..|      |:|  .|:.:::||..|||.:.:.:   ..|.|:.||||:||...|..
Zfish   634 SLDPEGDEEFRLDLMLVEHE--ELMEKINTWNFQIFELMDLTGGKTGRILSYVAYTLFQDTGLFE 696

  Fly   845 SLMIPPKTFLNFMSTLEDHYVKDNPFHNSLHAADVTQSTNVLL---------------------- 887
            ...||.:.|:.:...||:.| :|.|:||.:||.||..:...|.
Zfish   697 IFKIPVREFMTYFCALENGY-RDIPYHNRVHATDVLHAVWYLTTQPIPGFQQIHNEHVTGSDTDS 760

  Fly   888 -----------------------------NTPALEGVFTPLEVGGALF-AACIHDVDHPGLTNQF 922
                                         |.||||.:        ||: ||.:||.||||.||.|
Zfish   761 DSGISPGRVAYATSKSSSFQDDSYGCLAWNVPALELM--------ALYVAAAMHDYDHPGRTNAF 817

  Fly   923 LVNSSSELALMYNDESVLENHHLAVAFKL-LQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSK 986
            ||.:::..|::|||.|||||||.|.|:.| |.....:..||:...:.:..|.:||:.:|:||:.|
Zfish   818 LVATNAPQAVLYNDRSVLENHHAASAWSLFLSRPEFNFLCNLDHVEFKRFRFLVIEAILATDLKK 882

  Fly   987 HMSLLADLKTMVETKKVAGSGVLLLD--NYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLME 1049
            |...||:..:.|......|     :|  |..||:.|.:..:..||::.|.|...|:.:|...::.
Zfish   883 HFDFLAEFNSKVNDVNSPG-----IDWTNENDRLLVCQVCIKLADINGPAKDRSLHLKWTEGIVN 942

  Fly  1050 EFFLQGDKERESGMDISPMCDRHNATIEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEENR 1114
            ||:.|||:|...|:.|||..||....:.|.|..||.:||.||..::      ||..:|
Zfish   943 EFYEQGDEEGTLGLPISPFMDRSAPQLAKLQESFITHIVGPLCNSY------DAAGLL------- 994

  Fly  1115 DYYQSMIPPSPPPSGVDENPQEDRIRFQVTLEESDQENLAELEEGDE 1161
                       |...:||...:|        ||..::|..|.||.||
Zfish   995 -----------PGYWIDEEGSDD--------EEETEDNETEDEELDE 1022

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDE4_UCR	603..725	CDD:465648	33/141 (23%)
		PDEase_I	870..1110	CDD:459723	90/294 (31%)
pde3b	XP_691883.5	None