Protein Alignment dnc and pde11a

DIOPT Version :10

• Sequence 1: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Sequence 2: XP_689838.4
• Gene: pde11a / 561338
• ZFINID: ZDB-GENE-070912-207
• Length: 894
• Species: Danio rerio
• Alignment Length: 888
• Identity: 192/888 - (21%)
• Similarity: 318/888 - (35%)
• Gaps: 281/888 - (31%)

  Fly   482 SHPSNSQLLPTSKMQAEQGSIGD-LQKYHSRYLKNRRHTL-------ANVRFDVENGQGARSPL- 537
            |||...:...::..:....|.|| ||:..|:  |..|.|.       ||..:|......|:.||
Zfish    41 SHPKTPEKAASACAKDSWASRGDGLQRRASQ--KELRKTFARSKAINANRTYDEHVNSRAQEPLT 103

  Fly   538 ---------EGGS--PSAGLVLQ-------NLPQ----------------RRESFLYRSDSDFEM 568
                     :..|  |:...:|.       |:||                .||.||       |:
Zfish   104 SMRRRALLRKASSLPPTTAHILSALLESRVNIPQYPSTAVDYKYYLKEHNEREFFL-------EL 161

  Fly   569 SPKSMSRNSSIASERFK-----------EQEASILVDRSHGEDLIVTPFAQILAS---LRSVRNN 619
             .|.:|.:..:.|..:|           ::.:..||:....:..:|:.|..:.|.   |.|:.|:
Zfish   162 -VKDISNDLDLTSLSYKILVFVCIMVDADRCSLFLVEGPTNKKTLVSKFFDVHAGTTVLPSLSNS 225

  Fly   620 ----------LL-------SLTNVPASNKSRR-------------------PNQSSSASRSG--- 645
                      ::       ...|:|.:.:..|                   |..:|.....|
Zfish   226 DEVQVPWGKGIIGYVAEHGETVNIPDAYQDHRFSDEIDKLTGYKTKSLLCMPIHNSDGEVIGVAQ 290

  Fly   646 ----NPPGAPLSQGEE--------------AYTRLATDTIEELDWCLDQLETI------QT---- 682
                :|.||..:|.:|              :..:|...:.:|.|.....||.:      ||
Zfish   291 AINKSPNGALFTQDDEKVLQMYLPFCGIAISNAQLFAASRKEYDRSRALLEVVNDLFEEQTDLEK 355

  Fly   683 ------HRS-------------VSDMAS--LKFKR------------MLNKELSHFSESSRS--- 711
                  ||:             :.|:.|  :||.:            |.|.......:||.|
Zfish   356 IVRKIMHRAQTLLKCERCSVQLLEDIESPVVKFTKSFELLSPKCSADMENSFKDSMDKSSYSDWL 420

  Fly   712 -GNQISEYICSTFL-----DKQQE--FDLPSLRVEDNPELVAANAAAGQQSAGQYARS--RSPRG 766
             .|.|:|.:.||.|     |..|:  ||                 |...|.:|.:.||  ..|..
Zfish   421 INNSIAELVASTGLPVNISDAYQDPRFD-----------------AEADQFSGFHIRSVLCVPIW 468

  Fly   767 PPMSQISGVKRPLSHTNS----------------FTGERLPTFGVE------------------- 796
            ....||.||.:.|:..:.                |.|     .|:.
Zfish   469 NSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCG-----LGINNTIMYDQVKKSWAKQSVAL 528

  Fly   797 -------TPRENELG-------TLLGELDTWGIQIFSIGEFSVN-RPLTCVAYTIFQSRELLTSL 846
                   |..:.|:.       .|:.||   ||...|..:||:: ..:...|..:|....::...
Zfish   529 DVLSYHATCSKTEVDKFKAANIPLVCEL---GIDKLSFDDFSLDVDAMVTAALRMFMELGMVQKF 590

  Fly   847 MIPPKTFLNFMSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACI- 910
            .|..:|...::.|:..:| :...:||..||.:|.|....:|.|...:...|.:|. .||...||
Zfish   591 KIDYETLCRWLLTVRKNY-RMVLYHNWRHAFNVCQCMFSMLTTAGFQETLTEMET-LALIVGCIC 653

  Fly   911 HDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMV 975
            ||:||.|..|.|...:.|.|:|:|...:.||:||...|..:||::|.:||.|:...:...|.:::
Zfish   654 HDLDHRGTNNAFQAKTGSALSLLYGTSATLEHHHFNHAVMILQSEGHNIFSNLSSHEYGELMQLL 718

  Fly   976 IDIVLSTDMSKHMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLY 1040
            ...:|:||::.:..   :..:..|   :...|....:....|......|:...||...|||..:.
Zfish   719 KQSILATDLTLYFQ---NRNSFFE---LVNKGEYNWNVKEHREMCRSMLMTACDLGAVTKPWEIS 777

  Fly  1041 KRWVALLMEEFFLQGDKERESGMDISP--MCDRHNA-TIEKSQVGFIDYIVHPLWETWADLVHPD 1102
            .:...|:..|||.|||:|| |.:.::|  :.||:.. .:...|:.:||.|..||:||:|.| :|.
Zfish   778 HKVAELVTSEFFEQGDRER-SELKLTPSAIFDRNRKDELPGLQLEWIDGICAPLYETFAKL-NPK 840

  Fly  1103 AQDILDTLEENRDYYQSM------------IPPSPPPSGVDEN 1133
            .|.::|.::.||..::.:            ||.||..:.|..:
Zfish   841 LQPMMDLIKANRAKWEELHHRHQRISQEASIPASPDHAEVSSS 883

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDE4_UCR	603..725	CDD:465648	41/233 (18%)
		PDEase_I	870..1110	CDD:459723	75/243 (31%)
pde11a	XP_689838.4	GAF	170..330	CDD:214500	22/159 (14%)
		GAF	352..518	CDD:214500	35/187 (19%)
		PDEase_I	613..848	CDD:459723	75/243 (31%)