Protein Alignment dnc and pde5ab

DIOPT Version :10

• Sequence 1: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Sequence 2: XP_005166620.1
• Gene: pde5ab / 553270
• ZFINID: ZDB-GENE-060824-4
• Length: 868
• Species: Danio rerio
• Alignment Length: 916
• Identity: 195/916 - (21%)
• Similarity: 327/916 - (35%)
• Gaps: 190/916 - (20%)

  Fly   281 PSTNPCQ------SAVQNQGQNSNPNPNQNPNTNPNQNQQRCSCQPQTSPLPHIKEEEESDQANF 339
            ||..|.:      :||.:.|. ::..|:.:|  .|:...::.|......||..|..::......|
Zfish    49 PSREPSKAVPEPVTAVHSLGP-TDVVPSSSP--APSTPTRKISASEFDRPLRPIVVKDAEGSFTF 110

  Fly   340 KHQTSLKEHQPLPPPITIATGYCGSCESVHHSSATSSSAGTVPPGGQQTQ----------EYIAG 394
            ...|. :...||||                 |....|..||...||.:.:          |.:..
Zfish   111 LSDTE-RVQMPLPP-----------------SQRPGSDNGTDEGGGIRDRGNGDRCARLLELVRD 157

  Fly   395 TSSTPSPRIKLK------FRKPHKSCWSRIVLAPIGS---AGGSSSATTVIGSN-----SNETLA 445
            .||    .:.|.      |...|:     ::.|...|   .|..||....:.|.     ...||.
Zfish   158 VSS----HLDLTALCHKIFLHTHE-----LIAADRYSLFLVGEDSSNRKFLVSRLFDVAEGSTLE 213

  Fly   446 SSSTTGGTATTTQNSSSVSVAAHHRLTSSSASALATSHPSN-SQLLPTSKMQAEQGSIGDLQKYH 509
            .||.:|  .....|...|...|            ||..|.| ......|:..||   :..:..|.
Zfish   214 ESSNSG--IRLEWNKGIVGYVA------------ATGQPLNIKNAYEDSRFNAE---VDQITGYK 261

  Fly   510 SRY-----LKNRRHTLANVRFDVENGQGARSPLEGGSPS--------AGLVLQNLPQRRESFLYR 561
            ::.     :||.|..:..|...:....|..|........        :|:||.|      :.||
Zfish   262 TQSILCLPIKNHRDEVVGVAQAINKKCGENSTFTEQDEKDFSSYLAFSGIVLHN------AQLY- 319

  Fly   562 SDSDFEMSPKSMSRNS---SIASERFKEQEASILVDRSHGEDLIVTPFAQ---ILASLRSVRNNL 620
                 |.|.....||.   .:||..|:||::..::.|.....::....||   :..|.|...|..
Zfish   320 -----ETSQLENRRNQVLLDLASLIFEEQQSLEVLLRKTVATILSFMQAQECTVFISDRETANTF 379

  Fly   621 LSLTNV---PASNKSRRPNQSSSASRSGNPPGAPLSQGEEAYTRLATDTIEELDWCLDQLETIQT 682
            .|:.::   ..:..:..||:....::        ::.....|.:...:|:...|...|||
Zfish   380 ASVFHMEYEEIAGSTDFPNRECDVNK--------INYMYAQYVKNTMETLNITDTTKDQL----- 431

  Fly   683 HRSVSDMASLKFKRMLNKELSHFSESSRSGN-QISEYICSTFLDKQQE-----------FDLPSL 735
                               .|..||..:|.| ||...:|:...:.:::           .|..|.
Zfish   432 -------------------FSWTSEDPQSTNCQIKSLLCTPIRNGKKDKVIGVCQLVNKMDEASG 477

  Fly   736 RV-------EDNPELVAANAAAGQQSAGQY-ARSRSPRGPPMSQISGVKRPLSHTNSFTGERLPT 792
            .|       |...|..|.....|.|:...| |..|:     |::.......||:..|...|....
Zfish   478 EVKAFNRNDEQFLEAFAVFCGLGIQNTQMYEAVERA-----MAKQEVTLEVLSYHASAAEEETRA 537

  Fly   793 FGVETPRENELGTLLGELDTWGIQIFSIGEFSV-NRPLTCVAYTIFQSRELLTSLMIPPKTFLNF 856
            ..|...........|..:|      :|..:|.: :...|.....:|...:|:.:..|..|:...:
Zfish   538 LQVTAAATIPSAQSLRLMD------YSFSDFDLTDAETTQATIRMFVDLKLVQNFQIKYKSLCQW 596

  Fly   857 MSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQ 921
            :.:::.:|.|:..:||..||.:.:|....:|.:..::...:.||....:.|...||:||.|:.|.
Zfish   597 ILSVKKNYRKNVVYHNWRHAFNTSQCMFAVLKSGRVQNNLSDLETLALMIATLSHDLDHRGVNNS 661

  Fly   922 FLVNSSSELALMYNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSK 986
            ::..|...||.:| ..|.:|:||......:|.:.|..|...:...:.:...||:...:|:||::.
Zfish   662 YIKRSDHPLAQLY-CHSTMEHHHFDQCLMILNSPGNQILSGLSLDEYKATLKMIEKAILATDLAV 725

  Fly   987 HMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEEF 1051
            :|      |...|..::|.:.....::...|..:...|:...|:|..|||.|:.|:...|:..||
Zfish   726 YM------KKRTEFFELAKNSQFEWEDDCHRDLLRSMLMTACDISAITKPWPVQKKIAELVATEF 784

  Fly  1052 FLQGDKERESGMDISPMCDRHNA----TIEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEE 1112
            |.||||||.. ::|.|: |..|.    .|...||.|||.|...|:|.... :......:|:...:
Zfish   785 FEQGDKERRE-LNIEPI-DLMNREKQDKIPSMQVSFIDAICTQLYEALTG-ISEFCSPLLEGCRK 846

  Fly  1113 NRDYYQ 1118
            ||..::
Zfish   847 NRQNWK 852

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDE4_UCR	603..725	CDD:465648	22/128 (17%)
		PDEase_I	870..1110	CDD:459723	68/243 (28%)
pde5ab	XP_005166620.1	GAF	163..323	CDD:214500	38/193 (20%)
		GAF	346..511	CDD:214500	33/196 (17%)
		PDEase_I	610..844	CDD:459723	68/243 (28%)