DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dnc and PDE6B

DIOPT Version :9

Sequence 1:	NP_726846.1	Gene:	dnc / 31309	FlyBaseID:	FBgn0000479	Length:	1209	Species:	Drosophila melanogaster
Sequence 2:	XP_011511775.1	Gene:	PDE6B / 5158	HGNCID:	8786	Length:	941	Species:	Homo sapiens

Alignment Length:	388	Identity:	99/388 - (25%)
Similarity:	171/388 - (44%)	Gaps:	60/388 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   800 ENELGTLLGELDTWGIQIFSIGEFSVNRPLTCV-------AYTIFQSRELLTSLMIPPKTFLNFM 857
            |:|||.:|.| :..|...|.|.||..: .|.|.       ...::....::....||.:..:.|:
Human   555 EDELGEILKE-ELPGPTTFDIYEFHFS-DLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFL 617

  Fly   858 STLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQF 922
            .::...| :...:||..|..:|.|:...||.|..|:..:|.||....:.|...||:||.|..|.:
Human   618 FSISKGY-RRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLY 681

  Fly   923 LVNSSSELALMYNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKH 987
            .:.|.:.||.::. .|:||.|||.....||..:..:|:.|:.::|.:.:..::...:::||::.:
Human   682 QMKSQNPLAKLHG-SSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALY 745

  Fly   988 MSLLADLKTMVETKKVAGSGVLLLDNYTDRIQ--------------VLENLVHCADLSNPTKPLP 1038
            ....|..:.:|:..|          ||.|:..              |:..::...|||..|||..
Human   746 FKKRAMFQKIVDESK----------NYQDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWE 800

  Fly  1039 LYKRWVALLMEEFFLQGDKERESGMDIS--PMCDRHNAT-IEKSQVGFIDYIVHPLWETWADLVH 1100
            :..:...|:..||:.|||.|| :.:|..  ||.||:.|. :.|.||||||::...:::.::.. |
Human   801 VQSKVALLVAAEFWEQGDLER-TVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRF-H 863

  Fly  1101 PDAQDILDTLEENRDYYQS--------------------MIPPSPPPSGVDENPQEDRIRFQV 1143
            .:...:.|.|:.||..:::                    :.|.|..|.|....||....|..|
Human   864 EEILPMFDRLQNNRKEWKALADDRHRNLQWRPSTQVFNLLYPVSTGPMGTLWLPQSSPTRIWV 926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDEase_I	870..1111	CDD:278654	71/257 (28%)
PDE6B	XP_011511775.1	GAF	144..303	CDD:214500
		GAF	325..512	CDD:214500
		PDEase_I	629..874	CDD:278654	71/257 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820