Protein Alignment dnc and PDE9A

DIOPT Version :9

• Sequence 1: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Sequence 2: NP_002597.1
• Gene: PDE9A / 5152
• HGNCID: 8795
• Length: 593
• Species: Homo sapiens
• Alignment Length: 727
• Identity: 166/727 - (22%)
• Similarity: 298/727 - (40%)
• Gaps: 197/727 - (27%)

  Fly   454 ATTTQNSSSVSVAAHHRLTSSSAS-ALATSHPSNSQLLP--TSKMQAEQGSIGDLQKYHSRYLKN 515
            ||....::::|:     ||:..|. ::..:.|:||:..|  ...:..:|.|.|         :::
Human    42 ATGLPRNTTISL-----LTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAG---------VED 92

  Fly   516 RRHTLANVRFDVENGQGARSPLEGGSPSAGLVLQNLPQRRESFLYRSDSDFEMSPKS----MSRN 576
            :|.|        ..||.|..||.    ...:|....|:|..:|   .....|..|:.    ....
Human    93 KRTT--------SRGQSAERPLR----DRRVVGLEQPRREGAF---ESGQVEPRPREPQGCYQEG 142

  Fly   577 SSIASERFKEQEASILVDRSHGEDLIVTPFAQILASL-RSVRNNLLSLTNVPASNKSRRPNQSSS 640
            ..|..||               |:||.:..||:.... |:.:.|.|.
Human   143 QRIPPER---------------EELIQSVLAQVAEQFSRAFKINELK------------------ 174

  Fly   641 ASRSGNPPGAPLSQGEEAYTRLAT--DTIEELDWCLDQLETIQTHRSVSDMASLKFKRMLNKELS 703
                           .|....||.  ..:|     |:.|:.::..:..||:      :.:.:||:
Human   175 ---------------AEVANHLAVLEKRVE-----LEGLKVVEIEKCKSDI------KKMREELA 213

  Fly   704 HFSESSRSGNQISEYICSTFLDKQQEF----DLPSL-RVEDNPELVAANAAAGQQSAGQYARSRS 763
              :.|||: |...:|   :|||..::.    |:|:. :...:||.:.|
Human   214 --ARSSRT-NCPCKY---SFLDNHKKLTPRRDVPTYPKYLLSPETIEA----------------- 255

  Fly   764 PRGPPMSQISGVKRPLSHTNSFTGERLPTFGVETPRENELGTLLGELDTWGIQIFSIGEFSVNRP 828
                                    .|.|||                 |.|        .:..|..
Human   256 ------------------------LRKPTF-----------------DVW--------LWEPNEM 271

  Fly   829 LTCVAYTIFQSRELLTSLMIPPKTFLNFMSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALE 893
            |:|:.: ::....|:....|.|.|...::..:.|:| ::|||||..|...|.|....::...:|:
Human   272 LSCLEH-MYHDLGLVRDFSINPVTLRRWLFCVHDNY-RNNPFHNFRHCFCVAQMMYSMVWLCSLQ 334

  Fly   894 GVFTPLEVGGALFAACIHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNQGCD 958
            ..|:..::...:.||..||:||||..|.:.:|:.:|||:.|||.|.|||||.||||::|....|:
Human   335 EKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECN 399

  Fly   959 IFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLEN 1023
            ||.|:.....:.:|:.:|.::|:|||::|..::...|..:|....:.      :.:...::::
Human   400 IFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSN------EEHMTLLKMI-- 456

  Fly  1024 LVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKERESGMDISPMCDRHNATIEKSQVGFIDYIV 1088
            |:.|.|:||..:|:.:.:.||..|:||:|:|.|:|:..|:.::|..||...|...:|:|||.:::
Human   457 LIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVL 521

  Fly  1089 HPLWETWADLVHPDAQDILDTLEENRDYYQSMIPPSPPPSGVDENPQE-----DRIRFQVTLEES 1148
            .|::||...|.....:.:|..|.|:||.|:.:       ..:|:..:|     |.:....|.:..
Human   522 IPMFETVTKLFPMVEEIMLQPLWESRDRYEEL-------KRIDDAMKELQKKTDSLTSGATEKSR 579

  Fly  1149 DQENLAELEEGD 1160
            ::....:..|||
Human   580 ERSRDVKNSEGD 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDEase_I	870..1111	CDD:278654	77/240 (32%)
PDE9A	NP_002597.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	87..141		15/77 (19%)
		PDEase_I	311..539	CDD:278654	76/235 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	564..593		5/28 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2223
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850