DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dnc and PDE8A

DIOPT Version :9

Sequence 1:	NP_726846.1	Gene:	dnc / 31309	FlyBaseID:	FBgn0000479	Length:	1209	Species:	Drosophila melanogaster
Sequence 2:	NP_002596.1	Gene:	PDE8A / 5151	HGNCID:	8793	Length:	829	Species:	Homo sapiens

Alignment Length:	917	Identity:	219/917 - (23%)
Similarity:	375/917 - (40%)	Gaps:	204/917 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   323 SPLPHIKEEEESDQANFKHQTSLKEHQPLPPPITIATGYCGSCESVHHSSATSSSAGTVPPGGQQ 387
            :|..||.|...::.|          ..|..||:                    ||.|...|.||:
Human     4 APSIHISERLVAEDA----------PSPAAPPL--------------------SSGGPRLPQGQK 38

  Fly   388 TQEYIAGTSSTPSPR------IKLKFRKPHKSCWSRIVLAPIGSAGGSSSATTVIGSNSNET--- 443
                   |::.|..|      .:|:.....|...:.:...|:...........|.....|:.
Human    39 -------TAALPRTRGAGLLESELRDGSGKKVAVADVQFGPMRFHQDQLQVLLVFTKEDNQCNGF 96

  Fly   444 LASSSTTGGTATTTQNSSSVSVA---AHHRLTSSSASALATSHPSNSQL--------LPTSKMQA 497
            ..:....|...|.|:.:.:|...   .||.:       :...|.:..||        :.:||:..
Human    97 CRACEKAGFKCTVTKEAQAVLACFLDKHHDI-------IIIDHRNPRQLDAEALCRSIRSSKLSE 154

  Fly   498 EQGSIGDLQK---------------YHSRYLKNRRHTLA--NVRFDVENGQGARSPLE-GGSPSA 544
            ....:|.:::               :..||::| .:.:|  |....:|.|: .||.|: ....|.
Human   155 NTVIVGVVRRVDREELSVMPFISAGFTRRYVEN-PNIMACYNELLQLEFGE-VRSQLKLRACNSV 217

  Fly   545 GLVLQNLPQRRESFLYRSDSDFEMSPKSMSRNSSIASERFKE---QEASILVDRSHGEDLIVTPF 606
            ...|:|           |:...|::  |..|....|:..|:.   .::..|:.:..||..|....
Human   218 FTALEN-----------SEDAIEIT--SEDRFIQYANPAFETTMGYQSGELIGKELGEVPINEKK 269

  Fly   607 AQILASLRS-VR-----------------NNLLSLTNVPASNKSRRPNQSSSASR--SGNPPGAP 651
            |.:|.::.| :|                 |...::..:|...:..:.....|..|  :||.....
Human   270 ADLLDTINSCIRIGKEWQGIYYAKKKNGDNIQQNVKIIPVIGQGGKIRHYVSIIRVCNGNNKAEK 334

  Fly   652 LSQGEEAYTRLATDTIEELD---WCLD---------QLETIQTHRSVSDMASLKFKRMLNKELSH 704
            :|:..::.|.....|.:..|   ..||         ::.:.:.|.|::.:.|:..:..:.|.::.
Human   335 ISECVQSDTHTDNQTGKHKDRRKGSLDVKAVASRATEVSSQRRHSSMARIHSMTIEAPITKVINI 399

  Fly   705 FSESSRSG--------NQISEYICSTFLDKQQEFDLPSLRVEDNPELVAANAAAGQQSAGQYARS 761
            .:.:..|.        :::.|.:.:|.|...| |...    :|:|.  |.:...|..|.|
Human   400 INAAQESSPMPVTEALDRVLEILRTTELYSPQ-FGAK----DDDPH--ANDLVGGLMSDG----- 452

  Fly   762 RSPRGPPMSQISGVKRPLSHTNSFTGERLPTFGVETP-------------RENELGTLLGELDTW 813
                   :.::||.:..||..|:    ::.:..:.||             .|||        :.|
Human   453 -------LRRLSGNEYVLSTKNT----QMVSSNIITPISLDDVPPRIARAMENE--------EYW 498

  Fly   814 GIQIFSIGEFSVNRPLTCVAYTIFQSRELLTSLMIPPKTFLNFMSTLEDHYVKDNPFHNSLHAAD 878
            ...||.:...:.||||..:...:|....:...|.....|..:::..:|.:|...||:|||.|:||
Human   499 DFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEANYHSSNPYHNSTHSAD 563

  Fly   879 VTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQFLVNSSSELALMYNDESVLENH 943
            |..:|...|:...::....|::...||.||.||||||||.||.||.|:.||||::|||.:|||:|
Human   564 VLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESH 628

  Fly   944 HLAVAFKLLQ-NQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHM-----------SLLADLKT 996
            |.|:||:|.. :..|:||.||::...:|||:.:||:||:|:|:||.           ..||.|:.
Human   629 HAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATLEE 693

  Fly   997 MVETKKVAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKERES 1061
            ..||.|.......:|....:|..:...|:.|||:|||.:||.....|.|.:.||:|.|.|:|::.
Human   694 NGETDKNQEVINTMLRTPENRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQ 758

  Fly  1062 GMD-ISPMCDRHNATIEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEENRDYYQSMIPPS- 1124
            |:. :.|:.||:..:|.|||:.||||.:..:::.|...|  |..|::..|:.|..|::.:....
Human   759 GLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFV--DLPDLMQHLDNNFKYWKGLDEMKL 821

  Fly  1125 ----PPP 1127
                |||
Human   822 RNLRPPP 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDEase_I	870..1111	CDD:278654	100/253 (40%)
PDE8A	NP_002596.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..46		12/66 (18%)
		OmpR	82..>159	CDD:223816	13/83 (16%)
		REC	83..>170	CDD:302758	14/93 (15%)
		PAS_9	226..324	CDD:290162	16/99 (16%)
		PAS	230..324	CDD:238075	15/95 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..360		3/18 (17%)
		Involved in RAF1-binding. /evidence=ECO:0000269\|PubMed:23509299	454..461		2/6 (33%)
		PDEase_I	555..807	CDD:278654	100/253 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2223
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950