Protein Alignment dnc and PDE7A

DIOPT Version :9

• Sequence 1: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Sequence 2: NP_001229247.1
• Gene: PDE7A / 5150
• HGNCID: 8791
• Length: 482
• Species: Homo sapiens
• Alignment Length: 530
• Identity: 144/530 - (27%)
• Similarity: 237/530 - (44%)
• Gaps: 80/530 - (15%)

  Fly   626 VPASNKSRRP--NQSSSASRSGNPPGAPLSQGEEAYTRLATDTIEELDWCLDQLETIQTHRSVSD 688
            ||....|||.  :.|||::..|.|....|||...|   ::.|:                    ||
Human    16 VPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGA---ISYDS--------------------SD 57

  Fly   689 MASLKFKRMLN----KELSHFSESSRSGNQISEYICSTFLDKQQEFDLPSLRVEDNPELVAANAA 749
            ..:| :.|||.    :..:.| ||.|.|:.  .||.......|.|.::.          |:|...
Human    58 QTAL-YIRMLGDVRVRSRAGF-ESERRGSH--PYIDFRIFHSQSEIEVS----------VSARNI 108

  Fly   750 AGQQSAGQYAR-SRSPRGPPMSQISGVKRPLSHTNSFTGERLPTFGVETPRENELGTLLGELDTW 813
            ....|..:|.| ||..||..:|....:                   ::.....:...:|.::..|
Human   109 RRLLSFQRYLRSSRFFRGTAVSNSLNI-------------------LDDDYNGQAKCMLEKVGNW 154

  Fly   814 GIQIFSIGEFSVNRPLTCVAYTIFQSRELLTSLMIPPKTFLNFMSTLEDHYVKDNPFHNSLHAAD 878
            ...||.....:....|..:.:.:|....|:....:.......|:..:::.|...||:||::||||
Human   155 NFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAAD 219

  Fly   879 VTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQFLVNSSSELALMYNDESVLENH 943
            |||:.:..|..|.|....||.::..:|.||..||:||||:...||:.::..||.:|.:.||||||
Human   220 VTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENH 284

  Fly   944 HLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMVETKKVAGSGV 1008
            |...|..||:..|  :|.::..:.||.:...:..::|:||:|:....|:..::.::      .|.
Human   285 HWRSAVGLLRESG--LFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLD------RGD 341

  Fly  1009 LLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKERESGMDISPMCDRHN 1073
            |.|::...|..||:..:.|||:.||.:...|.|:|...:.||||.|||.|::..:.:||:||||.
Human   342 LCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHT 406

  Fly  1074 ATIEKSQVGFIDYIVHPLWETWADLVHPD-AQDILDTLEENRDYYQSMIPPSPPPSGVDEN---- 1133
            .:|...|:||:.|:|.||:..||...:.. :|.:|..:..|:..::.:..........|..
Human   407 ESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELN 471

  Fly  1134 ----PQEDRI 1139
                |||:|:
Human   472 SQLLPQENRL 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDEase_I	870..1111	CDD:278654	87/241 (36%)
PDE7A	NP_001229247.1	PDEase_I	211..444	CDD:395177	87/240 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820