Protein Alignment dnc and PDE6A

DIOPT Version :9

• Sequence 1: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Sequence 2: NP_000431.2
• Gene: PDE6A / 5145
• HGNCID: 8785
• Length: 860
• Species: Homo sapiens
• Alignment Length: 390
• Identity: 104/390 - (26%)
• Similarity: 184/390 - (47%)
• Gaps: 38/390 - (9%)

  Fly   800 ENELGTLL-GEL---DTWGIQIFSIGEFSVNRPLT------CVAYTIFQSRELLTSLMIPPKTFL 854
            |.||..:| .||   |.:.|..|...:.    |||      | ...::...:::....||.:..:
Human   484 EEELAEILQAELPDADKYEINKFHFSDL----PLTELELVKC-GIQMYYELKVVDKFHIPQEALV 543

  Fly   855 NFMSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLT 919
            .||.:|...|.|.. :||..|..:|.|:...||.|..|:..||.||....:.||..||:||.|..
Human   544 RFMYSLSKGYRKIT-YHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHDIDHRGTN 607

  Fly   920 NQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDM 984
            |.:.:.|.:.||.::. .|:||.|||.....||:::..:||.|:.::|.:....|:...:::||:
Human   608 NLYQMKSQNPLAKLHG-SSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIHMMDIAIIATDL 671

  Fly   985 SKHMSLLADLKTMVETKKVAGS-----GVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWV 1044
            :.:.......:.:|:..|...|     ..::|:.....| |:..::...|||..|||..:..:..
Human   672 ALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEI-VMAMMMTACDLSAITKPWEVQSQVA 735

  Fly  1045 ALLMEEFFLQGDKERE-SGMDISPMCDRHNA-TIEKSQVGFIDYIVHPLWETWADLVHPDAQDIL 1107
            .|:..||:.|||.||. ...:..||.||:.| .:.|.||||||::...:::.::.. |.:...:|
Human   736 LLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFVCTFVYKEFSRF-HEEITPML 799

  Fly  1108 DTLEENRDYYQSMIPPSPPPSGVDENPQEDRIRFQVTLEESDQENLAELEEGDESGGESTTTGTT 1172
            |.:..||..::::         .||...:.:::.:   ::..|::......|::.||..:..|.|
Human   800 DGITNNRKEWKAL---------ADEYDAKMKVQEE---KKQKQQSAKSAAAGNQPGGNPSPGGAT 852

  Fly  1173  1172
            Human   853  852

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDEase_I	870..1111	CDD:278654	74/247 (30%)
PDE6A	NP_000431.2	GAF	75..232	CDD:214500
		GAF	254..441	CDD:214500
		PDEase_I	558..802	CDD:365964	74/246 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	821..860		6/35 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820