DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dnc and PDE4D

DIOPT Version :9

Sequence 1:	NP_726846.1	Gene:	dnc / 31309	FlyBaseID:	FBgn0000479	Length:	1209	Species:	Drosophila melanogaster
Sequence 2:	NP_001098101.1	Gene:	PDE4D / 5144	HGNCID:	8783	Length:	809	Species:	Homo sapiens

Alignment Length:	979	Identity:	449/979 - (45%)
Similarity:	563/979 - (57%)	Gaps:	235/979 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 AAASLASGLVARRAEPETLSDASVSPTAVVQQQQQQQQQLQQP---LLQSQPHFVPSSGNILSQV 273
            |.|...||..:..|...||.    :|..:.:.:|..|..|:||   ||....|..|.
Human     8 APARAGSGEGSDSAGGATLK----APKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPP-------- 60

  Fly   274 TLYSGSNPSTNPCQSAVQNQGQNSNPNPNQNPNTNPNQNQQRCSCQPQTSPLPHIKEEEESDQAN 338
                                     |.|:..|       |.:|..||...|
Human    61 -------------------------PPPSPQP-------QPQCPLQPPPPP-------------- 79

  Fly   339 FKHQTSLKEHQPLPPPITIATGYCGSCESVHHSSATSSSAGTVPPGGQQTQEYIAGTSSTPSPRI 403
                       |||||                           ||
Human    80 -----------PLPPP---------------------------PP-------------------- 86

  Fly   404 KLKFRKPHKSCWSRIVLAPIGSAGGSSSATTVIGSNSNETLASSSTTGGTATTTQNSSSVSVAAH 468
                              |.|:|.|              ..|||..||  ....:..|......:
Human    87 ------------------PPGAARG--------------RYASSGATG--RVRHRGYSDTERYLY 117

  Fly   469 HRLTSSSASALATSHPSNSQLLPTSKMQAEQGSIGDLQKYHSRYLKNRRHTLANVRFDVENGQGA 533
            .|....::.|:.|.|...   |..|:|           .:.|.:...|       ||||:||..|
Human   118 CRAMDRTSYAVETGHRPG---LKKSRM-----------SWPSSFQGLR-------RFDVDNGTSA 161

  Fly   534 -RSPLEG-GSPSAGLVLQ-NL--PQRRESFLYRSDSDFEMSPKSMSRNSSIASERFKEQEASILV 593
             ||||:. .||.:||:|| |.  .|||||||||||||:::|||||||||||||:
Human   162 GRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASD----------- 215

  Fly   594 DRSHGEDLIVTPFAQILASLRSVRNNLLSLTNVPASNKSRRPNQSSSASRSGNPPGAPLSQGEEA 658
              .||:|||||||||:|||||:||||..:|||:    :.|.|::.|......:...|.::  |||
Human   216 --IHGDDLIVTPFAQVLASLRTVRNNFAALTNL----QDRAPSKRSPMCNQPSINKATIT--EEA 272

  Fly   659 YTRLATDTIEELDWCLDQLETIQTHRSVSDMASLKFKRMLNKELSHFSESSRSGNQISEYICSTF 723
            |.:||::|:||||||||||||:||..|||:|||.|||||||:||:|.||.||||||:||:|.:||
Human   273 YQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTF 337

  Fly   724 LDKQQEFDLPSLRVEDNPELVAANAAAGQQSAGQYARSRSPRGPPMSQISGVKRPLSHTNSFTGE 788
            ||||.|.::|                    |..|..:.:..|  |||||||||: |.|::|.|..
Human   338 LDKQHEVEIP--------------------SPTQKEKEKKKR--PMSQISGVKK-LMHSSSLTNS 379

  Fly   789 RLPTFGVETPRENELGTLLGELDTWGIQIFSIGEFSVNRPLTCVAYTIFQSRELLTSLMIPPKTF 853
            .:|.|||:|.:|:.|...|.:::.||:.:|.|.|.|.|||||.:.:||||.|:||.:..||..|.
Human   380 SIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTL 444

  Fly   854 LNFMSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGL 918
            :.::.||||||..|..:||::|||||.|||:|||:|||||.|||.||:..|:||:.||||||||:
Human   445 ITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGV 509

  Fly   919 TNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTD 983
            :||||:|::|||||||||.||||||||||.|||||.:.||||.|:.|||||:||||||||||:||
Human   510 SNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATD 574

  Fly   984 MSKHMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLM 1048
            |||||:||||||||||||||..|||||||||:||||||:|:|||||||||||||.||::|...:|
Human   575 MSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIM 639

  Fly  1049 EEFFLQGDKERESGMDISPMCDRHNATIEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEEN 1113
            ||||.|||:|||.||:||||||:|||::|||||||||||||||||||||||||||||||||||:|
Human   640 EEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDN 704

  Fly  1114 RDYYQSMIPPSPPPSGVDENPQE------DRIRFQVTLEESDQENLAELEEG-----DESGGEST 1167
            |::|||.||.||.|:  .::|:|      ::.:|::|||| |.|:..|.:.|     |.|..:|.
Human   705 REWYQSTIPQSPSPA--PDDPEEGRQGQTEKFQFELTLEE-DGESDTEKDSGSQVEEDTSCSDSK 766

  Fly  1168 TTGT 1171
            |..|
Human   767 TLCT 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDEase_I	870..1111	CDD:278654	191/240 (80%)
PDE4D	NP_001098101.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..107		41/248 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	343..364		8/42 (19%)
		PDEase_I	461..702	CDD:278654	191/240 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	710..729		8/20 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	739..809		13/33 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	409	1.000	Domainoid score	I695
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H129755
Inparanoid	1	1.050	749	1.000	Inparanoid score	I580
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	1	1.000	-	-		otm40691
orthoMCL	1	0.900	-	-		OOG6_100782
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4715
SonicParanoid	1	1.000	-	-		X171
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.760