DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dnc and PDE4C

DIOPT Version :9

Sequence 1:	NP_726846.1	Gene:	dnc / 31309	FlyBaseID:	FBgn0000479	Length:	1209	Species:	Drosophila melanogaster
Sequence 2:	NP_000914.2	Gene:	PDE4C / 5143	HGNCID:	8782	Length:	712	Species:	Homo sapiens

Alignment Length:	649	Identity:	371/649 - (57%)
Similarity:	466/649 - (71%)	Gaps:	60/649 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   524 RFDVENGQ--GARSPLEGGSPSAGLVLQ-NLP--QRRESFLYRSDSDFEMSPKSMSRNSSIASER 583
            |||:|||.  |.|:.....||..|.::| .:|  |||||||||||||:|:|||:||||||:||:
Human    81 RFDLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASD- 144

  Fly   584 FKEQEASILVDRSHGEDLIVTPFAQILASLRSVRNNLLSLTNVPASNKSRRPNQSSSASRSGNPP 648
                        .||||:|||||||:|||||:||:|:.:|..          .|...|::.| |.
Human   145 ------------LHGEDMIVTPFAQVLASLRTVRSNVAALAR----------QQCLGAAKQG-PV 186

  Fly   649 GAP-----LSQGEEAYTRLATDTIEELDWCLDQLETIQTHRSVSDMASLKFKRMLNKELSHFSES 708
            |.|     |...|:...:||.:|::|||||||||||:||..||.:|||.||||:||:||:|.||:
Human   187 GNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSET 251

  Fly   709 SRSGNQISEYICSTFLDKQQEFDLPSLRVEDNPELVAANAAAGQQSAGQYARSRSPRGPPMSQIS 773
            ||||||:||||..||||:|.|.:||.:..|:.|:                         |||:||
Human   252 SRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQ-------------------------PMSRIS 291

  Fly   774 GVKRPLSHTNSFTGERLPTFGVETPRENELGTLLGELDTWGIQIFSIGEFSVNRPLTCVAYTIFQ 838
            |: ..|.|:.|.:...:|.|||:|.:|.:|...|.:.:.||:.:|.:.|.|.|||||.:.::|||
Human   292 GL-HGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQ 355

  Fly   839 SRELLTSLMIPPKTFLNFMSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGG 903
            .|:||.:..||..|...::..||.||..:..:|||||||||.|||:|||.|||||.|||.||:..
Human   356 ERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILA 420

  Fly   904 ALFAACIHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQR 968
            ||||:.||||||||::||||:|::|||||||||.||||||||||.|||||.:.||||.|:..|||
Human   421 ALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQR 485

  Fly   969 QTLRKMVIDIVLSTDMSKHMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLENLVHCADLSNP 1033
            .:||:||||:||:|||||||:||||||||||||||...||||||||:||||||:|||||||||||
Human   486 LSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNP 550

  Fly  1034 TKPLPLYKRWVALLMEEFFLQGDKERESGMDISPMCDRHNATIEKSQVGFIDYIVHPLWETWADL 1098
            |||||||::|...:|.|||.|||:|||||:|||||||:|.|::|||||||||||.||||||||||
Human   551 TKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADL 615

  Fly  1099 VHPDAQDILDTLEENRDYYQSMIPPSPPPSGVDENPQEDRIRFQVTLEESDQENLAELEEGDES 1162
            |||||||:|||||:||::|||.||.||......|....||.:|::||||:::|:..|.|||:|:
Human   616 VHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDGPDRFQFELTLEEAEEEDEEEEEEGEET 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDEase_I	870..1111	CDD:278654	188/240 (78%)
PDE4C	NP_000914.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..64
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	181..200		5/19 (26%)
		PDEase_I	387..628	CDD:278654	188/240 (78%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	636..655		6/18 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	664..712		7/16 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	409	1.000	Domainoid score	I695
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	749	1.000	Inparanoid score	I580
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	1	1.000	-	-		otm40691
orthoMCL	1	0.900	-	-		OOG6_100782
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X171
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.730