DRSC/TRiP Functional Genomics Resources

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Protein Alignment dnc and PDE4C

DIOPT Version :10

Sequence 1:NP_726846.1 Gene:dnc / 31309 FlyBaseID:FBgn0000479 Length:1209 Species:Drosophila melanogaster
Sequence 2:NP_000914.2 Gene:PDE4C / 5143 HGNCID:8782 Length:712 Species:Homo sapiens


Alignment Length:649 Identity:371/649 - (57%)
Similarity:466/649 - (71%) Gaps:60/649 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly   524 RFDVENGQ--GARSPLEGGSPSAGLVLQ-NLP--QRRESFLYRSDSDFEMSPKSMSRNSSIASER 583
            |||:|||.  |.|:.....||..|.::| .:|  |||||||||||||:|:|||:||||||:||: 
Human    81 RFDLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASD- 144

  Fly   584 FKEQEASILVDRSHGEDLIVTPFAQILASLRSVRNNLLSLTNVPASNKSRRPNQSSSASRSGNPP 648
                        .||||:|||||||:|||||:||:|:.:|..          .|...|::.| |.
Human   145 ------------LHGEDMIVTPFAQVLASLRTVRSNVAALAR----------QQCLGAAKQG-PV 186

  Fly   649 GAP-----LSQGEEAYTRLATDTIEELDWCLDQLETIQTHRSVSDMASLKFKRMLNKELSHFSES 708
            |.|     |...|:...:||.:|::|||||||||||:||..||.:|||.||||:||:||:|.||:
Human   187 GNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSET 251

  Fly   709 SRSGNQISEYICSTFLDKQQEFDLPSLRVEDNPELVAANAAAGQQSAGQYARSRSPRGPPMSQIS 773
            ||||||:||||..||||:|.|.:||.:..|:.|:                         |||:||
Human   252 SRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQ-------------------------PMSRIS 291

  Fly   774 GVKRPLSHTNSFTGERLPTFGVETPRENELGTLLGELDTWGIQIFSIGEFSVNRPLTCVAYTIFQ 838
            |: ..|.|:.|.:...:|.|||:|.:|.:|...|.:.:.||:.:|.:.|.|.|||||.:.::|||
Human   292 GL-HGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQ 355

  Fly   839 SRELLTSLMIPPKTFLNFMSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGG 903
            .|:||.:..||..|...::..||.||..:..:|||||||||.|||:|||.|||||.|||.||:..
Human   356 ERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILA 420

  Fly   904 ALFAACIHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQR 968
            ||||:.||||||||::||||:|::|||||||||.||||||||||.|||||.:.||||.|:..|||
Human   421 ALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQR 485

  Fly   969 QTLRKMVIDIVLSTDMSKHMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLENLVHCADLSNP 1033
            .:||:||||:||:|||||||:||||||||||||||...||||||||:||||||:|||||||||||
Human   486 LSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNP 550

  Fly  1034 TKPLPLYKRWVALLMEEFFLQGDKERESGMDISPMCDRHNATIEKSQVGFIDYIVHPLWETWADL 1098
            |||||||::|...:|.|||.|||:|||||:|||||||:|.|::|||||||||||.||||||||||
Human   551 TKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADL 615

  Fly  1099 VHPDAQDILDTLEENRDYYQSMIPPSPPPSGVDENPQEDRIRFQVTLEESDQENLAELEEGDES 1162
            |||||||:|||||:||::|||.||.||......|....||.:|::||||:::|:..|.|||:|:
Human   616 VHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDGPDRFQFELTLEEAEEEDEEEEEEGEET 679

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dncNP_726846.1 PDE4_UCR 603..725 CDD:465648 67/126 (53%)
PDEase_I 870..1110 CDD:459723 187/239 (78%)
PDE4CNP_000914.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..31
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 45..64
PDE4_UCR 152..268 CDD:465648 67/126 (53%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 181..200 5/19 (26%)
PDEase_I 387..627 CDD:459723 187/239 (78%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 636..655 6/18 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 664..712 7/16 (44%)
Blue background indicates that the domain is not in the aligned region.

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