Protein Alignment dnc and PDE4B

DIOPT Version :10

• Sequence 1: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Sequence 2: NP_002591.2
• Gene: PDE4B / 5142
• HGNCID: 8781
• Length: 736
• Species: Homo sapiens
• Alignment Length: 778
• Identity: 423/778 - (54%)
• Similarity: 521/778 - (66%)
• Gaps: 111/778 - (14%)

  Fly   429 SSSATTVIGSNS---------NETLASSSTTGGTATTTQNSSSVSVAAHHRLTSSSASALATSHP 484
            |.|..||:..::         :::.:|||.|.|          :.:....|..|
Human     4 SRSVMTVMADDNVKDYFECSLSKSYSSSSNTLG----------IDLWRGRRCCS----------- 47

  Fly   485 SNSQLLPTSKMQAEQGSI--GD---------LQKYHSRYLKNRRHTLANVRFDVENGQG-ARSPL 537
            .|.||.|.|:.|:|:...  ||         |....|..:.    |::...||||||.. .||||
Human    48 GNLQLPPLSQRQSERARTPEGDGISRPTTLPLTTLPSIAIT----TVSQECFDVENGPSPGRSPL 108

  Fly   538 E-GGSPSAGLVLQ-NLP---QRRESFLYRSDSDFEMSPKSMSRNSSIASERFKEQEASILVDRSH 597
            : ..|.||||||. ..|   |||||||||||||:::|||:||||||:.||:             |
Human   109 DPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQ-------------H 160

  Fly   598 GEDLIVTPFAQILASLRSVRNNLLSLTNVPASNKSRRPNQSSSASRSGNPPGAPLSQGEEAYTRL 662
            |:|||||||||:||||||||||...|||:..::..|.|..|       .||.:.::..||:|.:|
Human   161 GDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAAS-------QPPVSRVNPQEESYQKL 218

  Fly   663 ATDTIEELDWCLDQLETIQTHRSVSDMASLKFKRMLNKELSHFSESSRSGNQISEYICSTFLDKQ 727
            |.:|:|||||||||||||||:||||:|||.|||||||:||:|.||.||||||:||||.:||||||
Human   219 AMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQ 283

  Fly   728 QEFDLPSLRVEDNPELVAANAAAGQQSAGQYARSRSPRGPPMSQISGVKRPLSHTNSFTGERLPT 792
            .:.::||...:|                    |.:..:...|:||||||: |.|::|.....:..
Human   284 NDVEIPSPTQKD--------------------REKKKKQQLMTQISGVKK-LMHSSSLNNTSISR 327

  Fly   793 FGVETPRENELGTLLGELDTWGIQIFSIGEFSVNRPLTCVAYTIFQSRELLTSLMIPPKTFLNFM 857
            |||.|..|:.|...|.:|:.||:.||::..:|.||||||:.|.|||.|:||.:..|...||:.:|
Human   328 FGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYM 392

  Fly   858 STLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQF 922
            .||||||..|..:|||||||||.|||:|||:||||:.|||.||:..|:|||.||||||||::|||
Human   393 MTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQF 457

  Fly   923 LVNSSSELALMYNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKH 987
            |:|::||||||||||||||||||||.|||||.:.||||.|:.|||||||||||||:||:||||||
Human   458 LINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKH 522

  Fly   988 MSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEEFF 1052
            ||||||||||||||||..||||||||||||||||.|:|||||||||||.|.||::|...:|||||
Human   523 MSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFF 587

  Fly  1053 LQGDKERESGMDISPMCDRHNATIEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEENRDYY 1117
            .|||||||.||:||||||:|.|::|||||||||||||||||||||||.|||||||||||:||::|
Human   588 QQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWY 652

  Fly  1118 QSMIPPSPPPSGVDENPQE-----DRIRFQVTLEESDQENLAELEEGDESGGE------STTT 1169
            |||||.||.|. :||..::     ::.:|::||:|.|       .||.|..||      ||.|
Human   653 QSMIPQSPSPP-LDEQNRDCQGLMEKFQFELTLDEED-------SEGPEKEGEGHSYFSSTKT 707

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDE4_UCR	603..725	CDD:465648	76/121 (63%)
		PDEase_I	870..1110	CDD:459723	193/239 (81%)
PDE4B	NP_002591.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	51..78		8/26 (31%)
		PDE4_UCR	166..281	CDD:465648	76/121 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	189..209		5/26 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	282..301		6/38 (16%)
		PDEase_I	405..645	CDD:459723	193/239 (81%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	685..736		10/30 (33%)