DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dnc and PDE4A

DIOPT Version :9

Sequence 1:	NP_726846.1	Gene:	dnc / 31309	FlyBaseID:	FBgn0000479	Length:	1209	Species:	Drosophila melanogaster
Sequence 2:	NP_001104777.1	Gene:	PDE4A / 5141	HGNCID:	8780	Length:	886	Species:	Homo sapiens

Alignment Length:	681	Identity:	393/681 - (57%)
Similarity:	478/681 - (70%)	Gaps:	63/681 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   524 RFDVENG---QGARSPLEGGSPSAGLVLQ---NLPQRRESFLYRSDSDFEMSPKSMSRNSSIASE 582
            ||:.|||   ...||||: ...|.||||.   ...|||||||||||||::||||:||||||:.||
Human   107 RFEAENGPTPSPGRSPLD-SQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSE 170

  Fly   583 RFKEQEASILVDRSHGEDLIVTPFAQILASLRSVRNNLLSLTNVPASNKSRRPNQSSSASRSGNP 647
                         :|.||||||||||:||||||||:|...|||||..:..|.|       ..|..
Human   171 -------------AHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSP-------LGGPT 215

  Fly   648 PGAPLSQGEEAYTRLATDTIEELDWCLDQLETIQTHRSVSDMASLKFKRMLNKELSHFSESSRSG 712
            |....:..||...:||.:|:|||||||:||||:||:||||:|||.|||||||:||:|.||.||||
Human   216 PVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSG 280

  Fly   713 NQISEYICSTFLDKQQEFDLPSLRVEDNPELVAANAAAGQQSAGQYARSRSPRGP-----PMSQI 772
            ||:||||.:||||||.|.::||..:::..          :|.|.:...|:.|..|     |||||
Human   281 NQVSEYISTTFLDKQNEVEIPSPTMKERE----------KQQAPRPRPSQPPPPPVPHLQPMSQI 335

  Fly   773 SGVKRPLSHTNSFTGERLPTFGVETPRENELGTLLGELDTWGIQIFSIGEFSVNRPLTCVAYTIF 837
            :|:|: |.|:||.....:|.|||:|.:|..|...|..|:.||:.||.:.:::..|.|||:.|.||
Human   336 TGLKK-LMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIF 399

  Fly   838 QSRELLTSLMIPPKTFLNFMSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVG 902
            |.|:||....||..|.:.:|.||||||..|..:|||||||||.|||:|||.||||:.|||.||:.
Human   400 QERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEIL 464

  Fly   903 GALFAACIHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQ 967
            .|||||.||||||||::||||:|::||||||||||||||||||||.|||||...||||.|:.|:|
Human   465 AALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQ 529

  Fly   968 RQTLRKMVIDIVLSTDMSKHMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLENLVHCADLSN 1032
            ||:|||||||:||:|||||||:||||||||||||||..|||||||||:||||||.|:||||||||
Human   530 RQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSN 594

  Fly  1033 PTKPLPLYKRWVALLMEEFFLQGDKERESGMDISPMCDRHNATIEKSQVGFIDYIVHPLWETWAD 1097
            |||||.||::|...:|.|||.|||:|||.||:||||||:|.|::|||||||||||||||||||||
Human   595 PTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 659

  Fly  1098 LVHPDAQDILDTLEENRDYYQSMI--PPSPPPS----GVDENPQEDRIRFQVTLEESDQENLAEL 1156
            |||||||:||||||:|||:|.|.|  .|||||.    |....|..|:.:|::||||.::|.::..
Human   660 LVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMA 724

  Fly  1157 EEGDESGGESTTTGTTGTTAASALSGAGGGG 1187
            :              ...||..||:..|..|
Human   725 Q--------------IPCTAQEALTAQGLSG 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDEase_I	870..1111	CDD:278654	190/240 (79%)
PDE4A	NP_001104777.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..128		9/21 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..331		10/46 (22%)
		PDEase_I	432..673	CDD:278654	190/240 (79%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	682..705		8/22 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	866..886
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	409	1.000	Domainoid score	I695
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	749	1.000	Inparanoid score	I580
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	1	1.000	-	-		otm40691
orthoMCL	1	0.900	-	-		OOG6_100782
Panther	1	1.100	-	-	O	PTHR11347
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X171
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.870