DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dnc and PDE2A

DIOPT Version :9

Sequence 1:NP_726846.1 Gene:dnc / 31309 FlyBaseID:FBgn0000479 Length:1209 Species:Drosophila melanogaster
Sequence 2:NP_002590.1 Gene:PDE2A / 5138 HGNCID:8777 Length:941 Species:Homo sapiens


Alignment Length:996 Identity:211/996 - (21%)
Similarity:345/996 - (34%) Gaps:295/996 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   314 QRCS----CQPQTSPLPHIKEEEESDQANFKHQTSLKEHQPLPPPITIATGYCGSCESVHHSSAT 374
            |.|.    |:.|..|.....|..       ..|..||..:|.|||...|...         ..|.
Human     3 QACGHSILCRSQQYPAARPAEPR-------GQQVFLKPDEPPPPPQPCADSL---------QDAL 51

  Fly   375 SSSAGTVPPGGQQTQEYIAGTSSTPSPRIKLKFR-------------KPHKSCWSRIVLAPIGSA 426
            .|....:...|  .|..:....|...||::..:.             .||:       |...|..
Human    52 LSLGSVIDISG--LQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHE-------LPQEGKV 107

  Fly   427 GGSSSATTVIGSNSNETLASSSTTGGTATTTQNSSSVSVAAHHRLTSSSASALATSHPSNSQLLP 491
            ..:..:...:|.|.   |..|...|....              ||.:..|        .::|:|.
Human   108 REAIISQKRLGCNG---LGFSDLPGKPLA--------------RLVAPLA--------PDTQVLV 147

  Fly   492 TSKMQAEQGSIGDLQKYHSRYLKN---------RRHTLANV-RFDVENGQGARSPLEGGSPSAGL 546
            ......|.|::..:...|...|.:         .:|||..: |..|...:|.|.     :|.|  
Human   148 MPLADKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVALRRVQVLQQRGPRE-----APRA-- 205

  Fly   547 VLQNLPQ--------------RRESFLYRSDSDFEMSPKSM-----------SRNSS----IASE 582
             :||.|:              |....|......:::...|:           :|.|.    :.||
Human   206 -VQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDLDASSLQLKVLQYLQQETRASRCCLLLVSE 269

  Fly   583 RFKEQEASILVDRSHGEDL---IVTPFAQILASLRSVRNNLLSLTN------------------- 625
            ...:....::.|:..||::   :.....|::...:|::  |..||:                   
Human   270 DNLQLSCKVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQ--LKDLTSEDVQQLQSMLGCELQAMLC 332

  Fly   626 VPASNKSRRPNQSSSASRSGNPPGAPLSQGEEAYTRLATDTIEE-LDWCLDQLETIQTHRSVSDM 689
            ||..  ||..:|..:.:.:.|.     .:|:     |.||..|. :..|.....|:.|    |.:
Human   333 VPVI--SRATDQVVALACAFNK-----LEGD-----LFTDEDEHVIQHCFHYTSTVLT----STL 381

  Fly   690 ASLKFKRM---------LNKEL-SHFSESS--------RSGNQISEYICSTFLDKQQE-----FD 731
            |..|.:::         :.|.| :|..:.|        .:.|..:..|||.||..|.|     ||
Human   382 AFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFD 446

  Fly   732 LPSLRVEDNPELVAANAAAGQQSAGQYARSRSPRGPPMSQISGVKRPLSH---------TNSFTG 787
              ...|:|  |.......|.|..||..|.:        .||..:....:|         :..|..
Human   447 --GGVVDD--ESYEIRIPADQGIAGHVATT--------GQILNIPDAYAHPLFYRGVDDSTGFRT 499

  Fly   788 ERLPTFGVETPRENELGT--LLGELD-TW----------------GIQI-FSIGEFSVN------ 826
            ..:..|.::...:..:|.  |:.::: .|                ||.| .|:....||      
Human   500 RNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRS 564

  Fly   827 --------------------------RPLTCV-------AYT---------------IFQSRELL 843
                                      :|:..:       .||               :.|....:
Human   565 HLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFI 629

  Fly   844 TSLMIPPKTFLNFMSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAA 908
            .:..|...|...|...::..| :|.|:||.:||..|:....:|.....|......:|: .|||.:
Human   630 NNYKIDCPTLARFCLMVKKGY-RDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEI-FALFIS 692

  Fly   909 CI-HDVDHPGLTNQFLVNSSSELALMYNDE-SVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTL 971
            |: ||:||.|..|.|.|.|.|.||.:|:.| ||:|.||.|.|..:|...||:||.:..:|..|.:
Human   693 CMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRM 757

  Fly   972 RKMVIDIVLSTDMSKHMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLENLVHC-----ADLS 1031
            ..::.||:|:||::.|:.:..||:.|.|.            .|....:....|:.|     .|||
Human   758 LDLMRDIILATDLAHHLRIFKDLQKMAEV------------GYDRNNKQHHRLLLCLLMTSCDLS 810

  Fly  1032 NPTKPLPLYKRWVALLMEEFFLQGDKERESGMDISPMCDRHNATIEKSQVGFIDYIVHPLWETWA 1096
            :.||.....::...|:.:|||.|||.|:..|.....|.||..|.|.:.|:.|:::|..|:::...
Human   811 DQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQ 875

  Fly  1097 DLVHPDAQDILDTLEENRDYY 1117
            || .|.|.::.:.:..||:::
Human   876 DL-FPKAAELYERVASNREHW 895

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dncNP_726846.1 PDEase_I 870..1111 CDD:278654 80/247 (32%)
PDE2ANP_002590.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 16..42 9/32 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 196..221 7/32 (22%)
GAF 241..387 CDD:214500 30/163 (18%)
GAF 409..558 CDD:214500 31/160 (19%)
PDEase_I 655..885 CDD:306695 80/243 (33%)
Substrate binding 656..660 2/3 (67%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3689
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D904682at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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