Protein Alignment dnc and PDE1C

DIOPT Version :10

• Sequence 1: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Sequence 2: XP_016867753.1
• Gene: PDE1C / 5137
• HGNCID: 8776
• Length: 804
• Species: Homo sapiens
• Alignment Length: 728
• Identity: 188/728 - (25%)
• Similarity: 304/728 - (41%)
• Gaps: 131/728 - (17%)

  Fly   567 EMSPKSMSRNS----SIASERFKEQEASILVDRSHGEDLIVTPFAQILASLRSVRNNLLSLTNVP 627
            |.||....|:|    :|.|   |:.|..:|..:..|......|:|     |.|..:....|....
Human    11 ESSPVFCLRSSHNGVAIVS---KQLECPLLGGQLRGCICCGKPWA-----LESHADLSCPLVANE 67

  Fly   628 ASNKSRRPNQSSSASRSGNPPGAPLSQG------EEAYTRLATDTIEELDWCLDQLETIQTHRSV 686
            |.:|:.||....|.|:|.|.....|..|      |:....:..|.....:...|:|..:.   |.
Human    68 AGDKNARPLARFSRSKSQNCLWNSLIDGLTGNVKEKPRPTIVHDPRPPEEILADELPQLD---SP 129

  Fly   687 SDMASLKFK-RMLNKELSHFSESSRSGNQISEYIC----STFLDKQQEFDLPSLRVEDNPELVAA 746
            ..:....|: |.|.|:|.....|.....:..||..    |.::|:.:..    |..||....:.:
Human   130 EVLVKTSFRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRL----LDTEDELSDIQS 190

  Fly   747 NAAAGQ----------QSAGQYARSRSPRGPPMSQI-----SG--VKRPLSHTNSFTGERLPTFG 794
            :|...:          :..|...| ||...|....|     :|  |:|....|::..|...|...
Human   191 DAVPSEVRDWLASTFTRQMGMMLR-RSDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAV 254

  Fly   795 VETPRENELGTLLGELDTWGIQIFSIGEFSVNRPLTCVAYTIFQSRELLTSLMIPPKTFLNFMST 859
            :|.         |.::|.|...:||:.|.|.:..|..:.|.:....:|::...||....::|:..
Human   255 IEA---------LKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEA 310

  Fly   860 LEDHYVK-DNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQFL 923
            ||..|.| .||:||.:|||||||:.:.||....:....|.||:...:|:|.|||.:|.|.||.|.
Human   311 LEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFH 375

  Fly   924 VNSSSELALMYNDESVLENHHLAVAFKLLQ-NQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKH 987
            :.:.|:.|::|||.||||||||:.|::||| ::..:|..|:.|...:..|.:||::|::||||.|
Human   376 IQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCH 440

  Fly   988 MSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEEFF 1052
            ...:..:||.::..:.           .::.:.|..::|.||:|:|.|...|:.||...|:||||
Human   441 FQQIKAMKTALQQPEA-----------IEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFF 494

  Fly  1053 LQGDKERESGMDISPMCDRHNATIEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEE----- 1112
            .|||:|.|.|:..||:|||.:..:.:|||||||:||.|.:....|:.......::|...:
Human   495 RQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDETSQTGGTG 559

  Fly  1113 ----------------------------------------------------NRDYYQSMIPPSP 1125
                                                                ||:.:::.:|...
Human   560 QRRSSLNSISSSDAKRSGVKTSGSEGSAPINNSVISVDYKSFKATWTEVVHINRERWRAKVPKEE 624

  Fly  1126 PPSGVDENPQEDRIRFQVTLEESDQENLAELEEGDESGGESTTTGTTGTTAASALSGAGGGGGGG 1190
            ..    :...|::.|.....::.:.|..::.|||.....|..|:|.|........:.......|.
Human   625 KA----KKEAEEKARLAAEEQQKEMEAKSQAEEGASGKAEKKTSGETKNQVNGTRANKSDNPRGK 685

  Fly  1191 GGMAPRTGGCQNQ 1203
            ...|.::.|.|.|
Human   686 NSKAEKSSGEQQQ 698

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDE4_UCR	603..725	CDD:465648	29/132 (22%)
		PDEase_I	870..1110	CDD:459723	93/240 (39%)
PDE1C	XP_016867753.1	PDEase_I_N	177..237	CDD:462497	12/64 (19%)
		PDEase_I	322..550	CDD:459723	92/238 (39%)