Protein Alignment dnc and PDE1A

DIOPT Version :10

• Sequence 1: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Sequence 2: XP_016859783.1
• Gene: PDE1A / 5136
• HGNCID: 8774
• Length: 586
• Species: Homo sapiens
• Alignment Length: 490
• Identity: 153/490 - (31%)
• Similarity: 246/490 - (50%)
• Gaps: 88/490 - (17%)

  Fly   663 ATDTIEELD---------------W--------CL-DQLE-----TIQTHRSVSDMASL------ 692
            ||: ||||:               |        || .|||     .:...:::...||:
Human     5 ATE-IEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYI 68

  Fly   693 -KFKRMLN--KELSHFSESSRSGNQISEYICSTFLDKQQEFDLPSLRVEDNPELVAANAAAGQQS 754
             :.:|:|:  .|||.....| ..:::.:::.|||..|   ..:...:.|:.|:..:...|.   .
Human    69 DETRRLLDTEDELSDIQTDS-VPSEVRDWLASTFTRK---MGMTKKKPEEKPKFRSIVHAV---Q 126

  Fly   755 AGQYARSRSPRGPPMSQISGVKRPLSHTNSFTGERLPTFGVETPRENELGTLLGELDTWGIQIFS 819
            ||.:                |:|....|....|...|...:.|         |.::|.|...:|:
Human   127 AGIF----------------VERMYRKTYHMVGLAYPAAVIVT---------LKDVDKWSFDVFA 166

  Fly   820 IGEFSVNRPLTCVAYTIFQSRELLTSLMIPPKTFLNFMSTLEDHYVK-DNPFHNSLHAADVTQST 883
            :.|.|....|..:.|.:|...:|:....||....:.|...||..|.| .||:||.:|||||||:.
Human   167 LNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTV 231

  Fly   884 N-VLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAV 947
            : ::|:|..:..: |.||:...:|||.|||.:|.|.||.|.:.:.|::|::|||.|||||||::.
Human   232 HYIMLHTGIMHWL-TELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSA 295

  Fly   948 AFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMVETKKVAGSGVLLLD 1012
            |::|:|.:..:|..|:.|...:.||.:||::|||||||.|...:.:::..::..:    |:
Human   296 AYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPE----GI---- 352

  Fly  1013 NYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKERESGMDISPMCDRHNATIE 1077
               ||.:.:..::|.||:|:|.|...|:.||...||||||||||||.|.|:..||:|||.:..:.
Human   353 ---DRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVA 414

  Fly  1078 KSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEE 1112
            :||:||||:||.|   |::.|.....:.::..:||
Human   415 QSQIGFIDFIVEP---TFSLLTDSTEKIVIPLIEE 446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDE4_UCR	603..725	CDD:465648	23/99 (23%)
		PDEase_I	870..1110	CDD:459723	97/240 (40%)
PDE1A	XP_016859783.1	PDEase_I_N	73..133	CDD:462497	16/82 (20%)
		PDEase_I	218..439	CDD:459723	97/235 (41%)