DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dnc and PDE11A

DIOPT Version :9

Sequence 1:	NP_726846.1	Gene:	dnc / 31309	FlyBaseID:	FBgn0000479	Length:	1209	Species:	Drosophila melanogaster
Sequence 2:	NP_058649.3	Gene:	PDE11A / 50940	HGNCID:	8773	Length:	933	Species:	Homo sapiens

Alignment Length:	963	Identity:	202/963 - (20%)
Similarity:	331/963 - (34%)	Gaps:	323/963 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   420 LAPIGSAGGSSSATTVIGSNSNETLASSSTTGGTATTTQNSSSVSVAAHHRLTSSSASALATSHP 484
            |.|..|..|:||            ||.|:..||        |||...     |..:.||.:...|
Human    49 LGPRPSLAGTSS------------LAHSTCRGG--------SSVGGG-----TGPNGSAHSQPLP 88

  Fly   485 SNSQL--LPTSKMQAEQGSIGD--LQKYHSRYLKNRRHTLA-------NVRFDVENGQGARSPLE 538
            .....  :|.|...| .||.||  ||:..|:  |..|.:.|       |..:|.:....|:.||.
Human    89 GGGDCGGVPLSPSWA-GGSRGDGNLQRRASQ--KELRKSFARSKAIHVNRTYDEQVTSRAQEPLS 150

  Fly   539 GG------------SPSAGLVLQ-------NLPQ----------------RRESFLYRSDSDFEM 568
            ..            .|:...:|.       |||:                .|:.||       |:
Human   151 SVRRRALLRKASSLPPTTAHILSALLESRVNLPRYPPTAIDYKCHLKKHNERQFFL-------EL 208

  Fly   569 SPKSMSRNSSIASERFKEQEASILV--------DR---------SHGEDLIVTPFAQI-----LA 611
             .|.:|.:..:.|..:|     ||:        ||         :.|:..:|:.|..:     |.
Human   209 -VKDISNDLDLTSLSYK-----ILIFVCLMVDADRCSLFLVEGAAAGKKTLVSKFFDVHAGTPLL 267

  Fly   612 SLRSVRN-NLLSL----------------TNVPASNKSRR-------------------PNQSSS 640
            ...|..| |.:.:                .|:|.:.:.||                   |.:||.
Human   268 PCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSD 332

  Fly   641 ASRSG-------NPPGAPLSQGEE-------------------------------AYTRLATDTI 667
            ....|       .|.|||.::.:|                               |...:..|..
Human   333 GEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLF 397

  Fly   668 EELDWCLDQLETIQTHRS-------------VSDMAS--LKFKR---MLNKELS-----HFSESS 709
            || ...|:::.....||:             :.|:.|  :||.:   :::.:.|     .|.||.
Human   398 EE-QTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESM 461

  Fly   710 RS--------GNQISEYICSTFL-----DKQQE--FDLPSLRVEDNPELVAANAAAGQQSAGQYA 759
            ..        .|.|:|.:.||.|     |..|:  ||                 |...|.:|.:.
Human   462 EKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFD-----------------AEADQISGFHI 509

  Fly   760 RS--RSPRGPPMSQISGVKRPLSHTNS----------------FTGERLPTFGVETPRENELGTL 806
            ||  ..|......||.||.:.|:..:.                |.|     .|:.       .|:
Human   510 RSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCG-----LGIN-------NTI 562

  Fly   807 LGE--LDTWGIQIFSIGEFS---------------VNRPLT---------------------CVA 833
            :.:  ..:|..|..::...|               .|.||.                     ..|
Human   563 MYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMITAA 627

  Fly   834 YTIFQSRELLTSLMIPPKTFLNFMSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTP 898
            ..:|....::....|..:|...::.|:..:| :...:||..||.:|.|....:|.|...:.:.|.
Human   628 LRMFMELGMVQKFKIDYETLCRWLLTVRKNY-RMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTE 691

  Fly   899 LEVGGALFAACIHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNQGCDIFCNM 963
            :|:...:.....||:||.|..|.|...|.|.||.:|...:.||:||...|..:||::|.:||.|:
Human   692 VEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANL 756

  Fly   964 QKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLENLVHCA 1028
            ..|:...|.:::...:|:||::.:.....:...:|.    .|.....:.|:.|..:.:  |:...
Human   757 SSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS----KGEYDWNIKNHRDIFRSM--LMTAC 815

  Fly  1029 DLSNPTKPLPLYKRWVALLMEEFFLQGDKER-ESGMDISPMCDRHNA-TIEKSQVGFIDYIVHPL 1091
            ||...|||..:.::...|:..|||.|||:|| |..:..|.:.||:.. .:.:.|:.:||.|..||
Human   816 DLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPL 880

  Fly  1092 WETWADLVHPDAQDILDTLEENRDYYQSMIPPSPPPSGVDENP------QEDR 1138
            ::.... |:...:.:||::..||..::.:.......|....:|      :|||
Human   881 YQALVK-VNVKLKPMLDSVATNRSKWEELHQKRLLASTASSSPASVMVAKEDR 932

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDEase_I	870..1111	CDD:278654	70/242 (29%)
PDE11A	NP_058649.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..125		30/103 (29%)
		GAF	217..380	CDD:214500	26/167 (16%)
		GAF	402..568	CDD:214500	36/194 (19%)
		PDEase_I	663..898	CDD:278654	70/241 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820