DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dnc and pde6c

DIOPT Version :9

Sequence 1:	NP_726846.1	Gene:	dnc / 31309	FlyBaseID:	FBgn0000479	Length:	1209	Species:	Drosophila melanogaster
Sequence 2:	NP_957165.1	Gene:	pde6c / 393845	ZFINID:	ZDB-GENE-040426-1664	Length:	852	Species:	Danio rerio

Alignment Length:	773	Identity:	165/773 - (21%)
Similarity:	302/773 - (39%)	Gaps:	217/773 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   476 ASALATSHPSN---------SQLL--PTSKMQAEQGSIGDLQK-YHS------RYLKNRRHTLAN 522
            |:.:|..|.:|         ||:|  ..||:..|   :.|::: :|.      .||:..|::...
Zfish   216 ATVIALQHYTNYMYNVESRRSQVLLWSASKVFEE---LTDIERQFHKALYTVRTYLQCERYSCGL 277

  Fly   523 VRF---------------DVENGQGARSP--------------LEG-------GSPSAG--LVLQ 549
            :..               |||..:|.::|              |||       .:|.|.  .::.
Zfish   278 LDMTKEKEFYDEWPIKLGDVEPYKGPKTPDGREIIFYKIIDYLLEGKEEIKVIPNPPADHWALVS 342

  Fly   550 NLPQRRESFLYRSDSDFEMSPKSMSRNSSIASERFKEQEASILVDRSHGEDLIVTPFAQILASLR 614
            .||      .|.:::.|..:..:::     |.|.|..|:.:  ||.        |.|
Zfish   343 GLP------TYVAENGFICNMMNVA-----ADEYFTFQKEA--VDE--------TGF-------- 378

  Fly   615 SVRNNLLSLTNVPASNKSRRPNQSSSASRSGNPPGAPLSQGEEAYTRLATDTIEELDWCLDQLET 679
             |..|:|||   |..||  :......|:......|.|..:.:|..|...|   :.|.|.:...:|
Zfish   379 -VIKNVLSL---PIVNK--KEEIVGVATFFNRKDGKPFEEQDEQITEALT---QFLGWSVLNCDT 434

  Fly   680 IQTHRSVSDMASLKFKRMLNKELSHFSESSRSGNQISEYICSTFLDKQQEFDLPSLRVEDNPELV 744
                  ...:..:::::.:.:|:..: ::..:..::.:     .|:.:::||       .|||
Zfish   435 ------YDKLNRMEWRKEIAEEMVMY-QTKATPAEVQQ-----ILNTKEKFD-------QNPE-- 478

  Fly   745 AANAAAGQQSAGQYARSRSPRGPPMS--QISGVKRPLSHTNSFTGERLPTFGVETPRENELGTLL 807
                ...|:...:..|:..|....:.  :.|....||:.|
Zfish   479 ----DCDQKEMYKLLRANIPEAKDVDLLEFSFSDFPLTET------------------------- 514

  Fly   808 GELDTWGIQ-IFSIGEFSVNRPLTCVAYTIFQSRELLTSLMIPPKTFLNFMSTLEDHYVKDNPFH 871
             :|...||: .|.:|                    ::....:|.:....:|.|:...| :|..:|
Zfish   515 -DLIKCGIRCFFELG--------------------VVEKFKVPAEVLTRWMYTVRKGY-RDITYH 557

  Fly   872 NSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQFLVNSSSELALMYND 936
            |..|..:|.|:...||.|..|...:|.|:....:.||..||:||.|..|.:...|:|.||.::.
Zfish   558 NWRHGFNVGQTMFCLLQTGKLRRYYTDLDAFAMVAAAFCHDIDHRGTNNLYQTKSASPLAKLHG- 621

  Fly   937 ESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMV--- 998
            .|:||.|||..:..|:..:..:||.::||:|.:|::.:....:::||::.:.......:.:|
Zfish   622 SSILERHHLQYSKNLMAEENVNIFQSLQKRQFETVQHLHDVCIIATDLALYFKKRTMFQKIVDAT 686

  Fly   999 -----ETKKVAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKE 1058
                 |.:.||.    :.:|...:..::..::...|||..|||..:..:...::..||:.|||.|
Zfish   687 EPMTKEEEMVAH----VANNPIRKEIIMAMMMTGCDLSAITKPWEVQSKVALMVAAEFWEQGDLE 747

  Fly  1059 RESGMDIS--PMCDRHNA-TIEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEENR------ 1114
            | :.:|..  ||.||:.: .:.|.|.||||::...:::.::.. |.:...:.|.|..||
Zfish   748 R-TVLDQQPIPMMDRNKSDELPKMQCGFIDFVCSFVYKEFSRF-HKEITPMFDGLNNNRVHWKEL 810

  Fly  1115 -DYYQSMIPPSPPPSGVDENPQEDRIRFQVTLEESDQENLAELEEGDESGGESTTTGT 1171
             |.||:.|         |....|.:     .|||.      :.::|.|.|||...:.|
Zfish   811 ADIYQAKI---------DAIANEKK-----RLEEE------QAKKGGEEGGEGGKSKT 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDEase_I	870..1111	CDD:278654	69/251 (27%)
pde6c	NP_957165.1	GAF	72..224	CDD:214500	2/7 (29%)
		GAF	252..439	CDD:214500	44/230 (19%)
		PDEase_I	556..801	CDD:278654	69/251 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920