DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dnc and pde6a

DIOPT Version :9

Sequence 1:	NP_726846.1	Gene:	dnc / 31309	FlyBaseID:	FBgn0000479	Length:	1209	Species:	Drosophila melanogaster
Sequence 2:	NP_001007161.1	Gene:	pde6a / 368410	ZFINID:	ZDB-GENE-030616-42	Length:	858	Species:	Danio rerio

Alignment Length:	383	Identity:	94/383 - (24%)
Similarity:	175/383 - (45%)	Gaps:	49/383 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   800 ENELGTLLGEL--DTWGIQIFSIG----EFSVNRPLTCVAYTIFQSRELLTSLMIPPKTFLNFMS 858
            |:||..:|.|:  |:...:||...    |||....:.| ...::....::....||.:|.:.|:.
Zfish   485 EDELEDILNEVLPDSEESEIFEFHFCDFEFSELDLVKC-GIKMYYELGVVDKFHIPRETLVRFVY 548

  Fly   859 TLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQFL 923
            ::...|.|.. :||..|..:|.|:...||.|..|:..:|.||....:.|...||:||.|..|.:.
Zfish   549 SVSKGYRKIT-YHNWRHGFNVGQTMFTLLMTGDLKRYYTDLEAMAMVTAGLCHDIDHRGTNNLYQ 612

  Fly   924 VNSSSELALMYNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHM 988
            :.|.:.||.::. .|:||.|||.....||:::..:|:.|:.::|.:|:..::...:::||::.:.
Zfish   613 MKSGNPLAKLHG-SSILERHHLEFGKTLLRDEALNIYQNLNRRQHETVIHLMDIAIIATDLALYF 676

  Fly   989 SLLADLKTMVETKKVAGSGVLLLDNYTDRIQ--------VLENLVHCADLSNPTKPLPLYKRWVA 1045
            ......:.:|:..|...|    .|::|..:.        |:..::...|||...||..:..:...
Zfish   677 KKRTMFQKIVDQSKTYDS----WDSWTKYMMLETTRKEIVMAMMMTACDLSAIAKPWEIQSKVAL 737

  Fly  1046 LLMEEFFLQGDKERE-SGMDISPMCDRHNA-TIEKSQVGFIDYIVHPLWETWADLVHPDAQDILD 1108
            .:..||:.|||.||. ......||.||:.| .:.|.|.||||::...:::.::.. |.:...:|:
Zfish   738 SVAAEFWEQGDLERTVLEQQPIPMMDRNKAEELPKLQCGFIDFVCSFVYKEFSRF-HVEITPMLE 801

  Fly  1109 TLEENRDYYQSMIPPSPPPSGVDENPQEDRIRFQVTLEESDQENLAELEEGDESGGES 1166
            .|..||..:.:                         |:|..:..:|:|:|..::..|:
Zfish   802 RLLNNRKEWNA-------------------------LKEIHEAKVAKLDEAKKAKEEA 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDEase_I	870..1111	CDD:278654	67/250 (27%)
pde6a	NP_001007161.1	GAF	74..233	CDD:214500
		GAF	255..442	CDD:214500
		PDEase_I	559..803	CDD:278654	67/249 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820