DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dnc and Pde6c

DIOPT Version :9

Sequence 1:	NP_726846.1	Gene:	dnc / 31309	FlyBaseID:	FBgn0000479	Length:	1209	Species:	Drosophila melanogaster
Sequence 2:	NP_001101992.1	Gene:	Pde6c / 361752	RGDID:	1309844	Length:	861	Species:	Rattus norvegicus

Alignment Length:	587	Identity:	134/587 - (22%)
Similarity:	236/587 - (40%)	Gaps:	150/587 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   616 VRNNLLSLTNVPASNKSRRPNQSSSASRSGNPPGAPLSQGEEAYTR----------LATDTIEEL 670
            |..|:|||   |..||  :.:....|:......|.|..:.:|..|.          |.|||.|.:
  Rat   383 VIKNVLSL---PIVNK--KEDIVGVATFYNRKDGKPFDEHDEHITETLTQFLGWSLLNTDTYERV 442

  Fly   671 DWCLDQLETIQ------THRSVSDMAS-LKFKRMLNKELSHFSESSRSGNQISEYICSTFLDKQQ 728
            :....:.:..|      |..:.|:::| ||||..||.::                     :::.:
  Rat   443 NKLESRKDIAQEMIMNLTKATPSEISSILKFKEKLNIDV---------------------IEECE 486

  Fly   729 EFDLPSLRVEDNPELVAANAAAGQQSAGQYARSRSPRGPPMSQISGVKRPLSHTNSFTGERLPTF 793
            |..|.::..|:.|:                     ||...:.:.                |...|
  Rat   487 ERQLLAILKEELPD---------------------PRAADLYEF----------------RFSDF 514

  Fly   794 GVETPRENELGTLLGELDTWGIQIFSIGEFSVNRPLTCVAYTIFQSRELLTSLMIPPKTFLNFMS 858
            .|   .|:||...       |:::|    ..:|               ::....:|.:....:|.
  Rat   515 PV---TEHELVKC-------GLRLF----LEIN---------------VVEKFKVPVEVLTRWMY 550

  Fly   859 TLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQFL 923
            |:...| :...:||..|..:|.|:...||.|..|:..:|.||....|.||..||:||.|..|.:.
  Rat   551 TVRKGY-RPVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQ 614

  Fly   924 VNSSSELALMYNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHM 988
            :.|:|.||.::. .|:||.|||..:..|||::..:||.|:.|:|.:|:..:....:::||::.:.
  Rat   615 MKSTSPLARLHG-TSILERHHLEYSKTLLQDESLNIFQNLSKRQFETVIHLFEVAIIATDLALYF 678

  Fly   989 SLLADLKTMVET-----------KKVAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKR 1042
            ......:.:|:|           |.|..       :.|.:..::..::...|||..|||..:..:
  Rat   679 KKRTMFQKIVDTCEQMQSEEETIKYVTA-------DPTKKEVIMAMMMTACDLSAITKPWEVQSQ 736

  Fly  1043 WVALLMEEFFLQGDKERE-SGMDISPMCDRH-NATIEKSQVGFIDYIVHPLWETWADLVHPDAQD 1105
            ...|:..||:.|||.||. ......||.||: ...:.|.||||||::...:::.::.. |.:...
  Rat   737 ATLLVANEFWEQGDLERTVLQQQPIPMMDRNKKGELPKLQVGFIDFVCTFVYKEFSRF-HGEITP 800

  Fly  1106 ILDTLEENRDYYQSMIPPSPPPSGVDENPQEDRIRFQVTLEESDQENLAELEEGDESGGESTTTG 1170
            :|..|:.||..::|:             .:|...:.:||     :|.:.:.||....|..:|..|
  Rat   801 MLTGLQNNRVEWKSL-------------AEEYEAKVKVT-----EEEVGKQEEVTSDGKAATDLG 847

  Fly  1171 TT 1172
            ::
  Rat   848 SS 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDEase_I	870..1111	CDD:278654	74/253 (29%)
Pde6c	NP_001101992.1	GAF	81..232	CDD:214500
		GAF	256..443	CDD:214500	18/64 (28%)
		PDEase_I	561..806	CDD:278654	74/253 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820