Protein Alignment dnc and Pde9

DIOPT Version :9

• Sequence 1: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Sequence 2: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Alignment Length: 1265
• Identity: 282/1265 - (22%)
• Similarity: 452/1265 - (35%)
• Gaps: 386/1265 - (30%)

  Fly   101 RGGGSAAPATSPPQTPAQTPDELKVIPEDCNLEKSAEQKRDLLERNNKEDDLLNRTVSGSELDLY 165
            ||..|||.|||...|.|:|...........:.|::.|..           .::..|::.|  |::
  Fly    14 RGSSSAAAATSTAATAAETAAAAAATTTSSSDEETLETL-----------TIITTTITDS--DIH 65

  Fly   166 GGAGGGTKKHSLADTIDTSVTTPISLKTLI-----NDVDE---------------ELDQQLSAAD 210
            ......|...|...|...:..|..:|.||.     :|:::               |:|.|.:|.:
  Fly    66 ATTTTTTVIASGTATTAAAAATTATLATLATLASNSDIEDSSPVESEDSEECEYIEIDCQTTAQE 130

  Fly   211 IAAASLASGLVARRAEPETLSDASVSPTAVVQQQQQQQQQLQQPLLQSQPHFVPSSGNILSQV-- 273
               .:..||..:.......|..:|.:.....||||||||.||..|.|:....:...|.|.|:|
  Fly   131 ---GTSPSGGSSSSGNAVLLQRSSNNLQQQQQQQQQQQQHLQLQLQQADERLLRKIGYIASRVRC 192

  Fly   274 -TLYSGSNPSTNP-------------------------------------------------CQS 288
             :.|.|.....||                                                 |.|
  Fly   193 LSKYYGDFRLVNPYSARRQRRQLQEILLRHSIFDPGKEHQRAIVLAAATAAIAGPLAAIDCVCGS 257

  Fly   289 ------AVQNQGQNSNPNPNQNPNTNPNQNQQRCSCQPQTSPLPHIKEEEESDQANFKHQTSLKE 347
                  ||.::.::|....:.:......:.|::...|..|.     ..|||.:..:.|.:.:..|
  Fly   258 SSISLEAVSSRSRSSELEDDHHEQDQVQEEQEQEQHQGDTE-----DNEEEQEHPSEKPERTDIE 317

  Fly   348 HQPLPPPITIATGYCGSCESVHHSSATSSSAGTVPPGGQQTQEYIAGTSSTPSPRIKLKFRKPHK 412
            .:| ||.|.:.|   .:..:|...|::||:              |:|| :|.|..:.:.......
  Fly   318 EEP-PPAIAVTT---TTTATVRRKSSSSST--------------ISGT-ATVSGSVSVSASASQS 363

  Fly   413 SCWSRI-----VLAPIGSAGGSSSATTVIGSN---------SNETLASSSTTGGTATTTQNSSSV 463
            .|.:.|     :|..........|..|||..:         ..:.:.:::.......:.||::::
  Fly   364 FCSNNINLLEELLIQFYEEQDHRSNLTVIRHHHHQQHQQHQQQQRITNNNNNNNNCNSIQNNNNM 428

  Fly   464 SVAAHHRLTSSSASALATSHPS----------NSQLLPTSKMQAEQGSIGDLQKYHS------RY 512
            |        :.:|:|.||:.||          |..|.|||   ...||....::..|      ..
  Fly   429 S--------NPAATAAATATPSVEQPATSGTTNIHLQPTS---LPDGSDNPRRRRASDCSAVQAA 482

  Fly   513 LKNRRH--TLANVRFDVENGQGARSPLEGGSPSAG----LVLQNLPQRRESFLYRSDS--DFEMS 569
            |:|:.|  ||.|      |..|...|...||..|.    |...::..|....|.:|.|  |.:.:
  Fly   483 LQNQLHCITLKN------NNCGKAMPFHRGSCGAAGEHLLAANSIANRATIILSKSCSNVDGDAT 541

  Fly   570 PKSMSRNSSIASERFKEQEASILVDRSHGEDLIVTPFAQILASLRSVRNNLLSLTN--VPASNKS 632
            ..:.:..||...........||                ::.||...:..|.|:...  :.|||..
  Fly   542 ATAATALSSTVGGGIGGIGGSI----------------KMRASATDIETNALNGARDAIVASNNG 590

  Fly   633 RRPNQSSSASRSGNPPGAPLSQGEEAYTRL-ATDTIEELDWCLDQLETIQTHRSVSDMASLKFKR 696
            ...|       :||       .|...|:.| ..:||            ||.|.:..|.      |
  Fly   591 NNGN-------NGN-------NGNNEYSILQLNNTI------------IQCHFNDDDF------R 623

  Fly   697 MLNKELSHFSESSRSGNQISEYICSTFLDKQQEFDLPSLRVEDNPELVAANAAAGQQSAGQYARS 761
            .|.|:|....|.:...|    ::|                                       .|
  Fly   624 ALVKDLKRKVEYTERMN----WLC---------------------------------------LS 645

  Fly   762 RSPRGPPMSQIS-----GVKRPLSH--TNSFTGE-----RLPTFGVETPRENELGTLLGELDTWG 814
            :.|.|||..:.|     .|||....  ..:|:.|     |||.|                 |::
  Fly   646 KRPLGPPHRKSSLPKHQEVKRRFLEICDTTFSEEVRAALRLPAF-----------------DSY- 692

  Fly   815 IQIFSIGEFSVNRPLTCVAYTIFQSRELLTSLMIPPKTFLNFMSTLEDHYVKDNPFHNSLHA--- 876
                   |:| :..:..:..|:|.....:....||..|...::..:..|| .:.||||..|.
  Fly   693 -------EWS-DADVIHLMQTMFVELGFIEKFSIPVDTLREWLYEVYKHY-NEVPFHNFRHCFCV 748

  Fly   877 ----ADVTQSTNVLLNTPALEGVFTPLEVGGALFAACI-HDVDHPGLTNQFLVNSSSELALMYND 936
                ..:|:..|:|.....||.:.        |..:|| ||:||||..|.:.:|:.:||||.|||
  Fly   749 AQMMYAITRQANLLSRLGDLECLI--------LLVSCICHDLDHPGYNNIYQINARTELALRYND 805

  Fly   937 ESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMVETK 1001
            .|.|||||.::||:||::..|:||.|..:.....:|:.:|..:|:|||::|..:|.....:..
  Fly   806 ISPLENHHCSIAFRLLEHPECNIFKNFSRDTFNNIREGIIRCILATDMARHNEILTQFMEITP-- 868

  Fly  1002 KVAGSGVLLLDNYTDRIQVLEN-----LVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKERES 1061
                     :.:|::|..:  |     |:..||:||..:|:.:.:.|:..|::|||.|...|:..
  Fly   869 ---------IFDYSNRAHI--NLLCMILIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEKSE 922

  Fly  1062 GMDISPMCDRHNATIEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEENRDYYQSMIPPSPP 1126
            |:.::|..|....:...|||.||..::.||:|...:||....:.|:..:....:||:.:
  Fly   923 GLPVTPFMDPDKVSKPGSQVRFIGLVLLPLFEALGELVPELTELIIIPVRIALEYYRRL------ 981

  Fly  1127 PSGVDENPQEDRIRFQVTLEESDQENLAELEEGDESGGESTTTGTTGTTAA-------------- 1177
                  |..:.:.|..|.             :.:.|....:.:||..:.||
  Fly   982 ------NDAQTKTRKSVA-------------DSNTSATSDSNSGTIDSNAAMVSTPGGASDKLSL 1027

  Fly  1178 ------SALSGAGGGGGGGGGMAPRTG-GC 1200
                  |..||.|||||||||....|| ||
  Fly  1028 DKGQGNSQGSGGGGGGGGGGGAGGGTGSGC 1057

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDEase_I	870..1111	CDD:278654	79/253 (31%)
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	78/248 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45459136
Domainoid	1	1.000	82	1.000	Domainoid score	I1950
eggNOG	1	0.900	-	-		E1_KOG3689
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46491
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11347
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2223
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.880