DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dnc and Pde7b

DIOPT Version :9

Sequence 1:	NP_726846.1	Gene:	dnc / 31309	FlyBaseID:	FBgn0000479	Length:	1209	Species:	Drosophila melanogaster
Sequence 2:	NP_001334295.1	Gene:	Pde7b / 29863	MGIID:	1352752	Length:	498	Species:	Mus musculus

Alignment Length:	474	Identity:	137/474 - (28%)
Similarity:	212/474 - (44%)	Gaps:	67/474 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   706 SESSRSGNQ-------ISEYICSTFLDKQQEFDLPSLRVEDNPELVAANAAAGQQSAGQYARSRS 763
            |.|||.|.|       :.|.|....|..:.:.:|.:.:    |..:..|..|.....|. .|.|.
Mouse    27 SLSSRPGCQQGPLPWDLPEMIRMVKLVWKSKSELQATK----PRGILENEDASHSFPGD-VRLRG 86

  Fly   764 PRGPPMSQ----------------ISG-------VKRPLSHTNSFTGERL-----PTFGVETPRE 800
            ..|.|..:                .||       |||.||....|...||     |...:....|
Mouse    87 QTGVPAERRGSYPFIDFRLLNNTTHSGEIGTKKKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDE 151

  Fly   801 NELGT---LLGELDTWGIQIFSIGEFSVNRPLTCVAYTIFQSRELLTSLMIPPKTFLNFMSTLED 862
            :.||.   :|.::.||...||.....:....|..:...:|.|..|:....:...|...|:..:::
Mouse   152 DYLGQARHMLSKVGTWDFDIFLFDRLTNGNSLVTLLCHLFNSHGLIHHFKLDMVTLHRFLVMVQE 216

  Fly   863 HYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQFLVNSS 927
            .|...||:||::|||||||:.:..|..|.|....|||::...|.||..|||||||:...||:.::
Mouse   217 DYHGHNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTN 281

  Fly   928 SELALMYNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLA 992
            ..||.:|.:.|||||||......:|:..  .:..::.|:..|.:.:.:..::|:||:::....|.
Mouse   282 HHLANLYQNMSVLENHHWRSTIGMLRES--RLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLT 344

  Fly   993 DLKTMVETKKVAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDK 1057
            .||..:..|.      |.|:|..||..:|:..:.|||:.||.:...:.|:|...:.|||:.|||.
Mouse   345 RLKAHLHNKD------LRLENVQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGDL 403

  Fly  1058 ERESGMDISPMCDRHNATIEKSQVGFIDYIVHPLWETWA--------------DLVHPDAQ--DI 1106
            |::..::|||:|::...:|...|:||:.|||.||:..||              .|.|..||  .:
Mouse   404 EQKFELEISPLCNQQKDSIPSIQIGFMTYIVEPLFREWARFTGNSTLSENMLSHLAHNKAQWKSL 468

  Fly  1107 LDTLEENRDYYQSMIPPSP 1125
            |......|...|.:..|:|
Mouse   469 LSNQHRRRGSGQDLAGPAP 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDEase_I	870..1111	CDD:278654	87/256 (34%)
Pde7b	NP_001334295.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820