DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dnc and Pde6b

DIOPT Version :9

Sequence 1:	NP_726846.1	Gene:	dnc / 31309	FlyBaseID:	FBgn0000479	Length:	1209	Species:	Drosophila melanogaster
Sequence 2:	NP_001099494.1	Gene:	Pde6b / 289878	RGDID:	1311039	Length:	856	Species:	Rattus norvegicus

Alignment Length:	415	Identity:	105/415 - (25%)
Similarity:	190/415 - (45%)	Gaps:	58/415 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   788 ERLPT---FGVETP--RENELGTLLGELDTWGIQIFSIGEFSVNRPLTCV-------AYTIFQSR 840
            |.|||   .|.|..  .|:|||.:|.| :..|...|.|.||..: .|.|.       ...::...
  Rat   465 EILPTRDRLGKEPADCEEDELGKILKE-ELPGPTKFDIYEFHFS-DLECTELELVKCGIQMYYEL 527

  Fly   841 ELLTSLMIPPKTFLNFMSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGAL 905
            .::....||.:..:.|:.::...| :...:||..|..:|.|:...||.|..|:..:|.||....:
  Rat   528 GVVRKFQIPQEVLVRFLFSVSKAY-RRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMV 591

  Fly   906 FAACIHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQT 970
            .|...||:||.|..|.:.:.|.:.||.::. .|:||.|||.....||..:..:|:.|:.::|.:.
  Rat   592 TAGLCHDIDHRGTNNLYQMKSQNPLAKLHG-SSILERHHLEFGKFLLAEESLNIYQNLNRRQHEH 655

  Fly   971 LRKMVIDIVLSTDMSKHMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQ--------------VL 1021
            :..::...:::||::.:.......:.:|:..|          ||.|:..              |:
  Rat   656 VIHLMDIAIIATDLALYFKKRTMFQKIVDESK----------NYEDKKSWVEYLSLETTRKEIVM 710

  Fly  1022 ENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKERESGMDIS--PMCDRHNAT-IEKSQVGF 1083
            ..::...|||..|||..:..:...|:..||:.|||.|| :.:|..  ||.||:.|. :.|.||||
  Rat   711 AMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLER-TVLDQQPIPMMDRNKAAELPKLQVGF 774

  Fly  1084 IDYIVHPLWETWADLVHPDAQDILDTLEENRDYYQSMIPPSPPPSGVDENPQEDRIRFQVTLEES 1148
            ||::...:::.::.. |.:...:.|.|:.||..::::         .||  .|.:::.....::.
  Rat   775 IDFVCTFVYKEFSRF-HEEILPMFDRLQNNRKEWKAL---------ADE--YEAKVKALEEEKKK 827

  Fly  1149 DQENLAELEEGDE--SGGESTTTGT 1171
            :::.:|..:.|.|  :||.:..:.|
  Rat   828 EEDRVAAKKAGTEICNGGPAPKSST 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDEase_I	870..1111	CDD:278654	70/257 (27%)
Pde6b	NP_001099494.1	GAF	71..230	CDD:214500
		GAF	252..439	CDD:214500
		PDEase_I	556..801	CDD:278654	70/257 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820