DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dnc and Pde4d

DIOPT Version :9

Sequence 1:	NP_726846.1	Gene:	dnc / 31309	FlyBaseID:	FBgn0000479	Length:	1209	Species:	Drosophila melanogaster
Sequence 2:	NP_001106799.1	Gene:	Pde4d / 24627	RGDID:	3281	Length:	803	Species:	Rattus norvegicus

Alignment Length:	975	Identity:	445/975 - (45%)
Similarity:	557/975 - (57%)	Gaps:	241/975 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 VARRAEPETLSDAS-----VSPTAVVQQQQQQQQQLQQP---LLQSQPHFVPSSGNILSQVTLYS 277
            |..||..:..||:|     .:|..:.:.:|..|..|:||   ||....|..|.
  Rat     8 VPARAGSDEGSDSSGGAALKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPP------------ 60

  Fly   278 GSNPSTNPCQSAVQNQGQNSNPNPNQNPNTNPNQNQQRCSCQPQTSPLPHIKEEEESDQANFKHQ 342
                                 |.|:..|...|          |...|||
  Rat    61 ---------------------PPPSPQPQLQP----------PPPPPLP---------------- 78

  Fly   343 TSLKEHQPLPPPITIATGYCGSCESVHHSSATSSSAGTVPPGGQQTQEYIAGTSSTPSPRIKLKF 407
                     |||                           ||.|.....|    :|:.:.|::
  Rat    79 ---------PPP---------------------------PPPGATRGRY----ASSGASRVR--- 100

  Fly   408 RKPHKSCWSRIVLAPIGSAGGSSSATTVIGSNSNETLASSSTTGGTATTTQNSSSVSVAAHHR-- 470
               |:                                ..|.|.........:.:|.:|...||
  Rat   101 ---HR--------------------------------GYSDTERYLYCRAMDRTSYAVETGHRPG 130

  Fly   471 LTSSSASALATSHPSNSQLLPTSKMQAEQGSIGDLQKYHSRYLKNRRHTLANVRFDVENGQGA-R 534
            |..|     ..|.||:.|.|.                                ||||:||..| |
  Rat   131 LKKS-----RMSWPSSFQGLR--------------------------------RFDVDNGTSAGR 158

  Fly   535 SPLEG-GSPSAGLVLQ-NL--PQRRESFLYRSDSDFEMSPKSMSRNSSIASERFKEQEASILVDR 595
            |||:. .||.:||:|| |.  .|||||||||||||:::|||||||||||||:
  Rat   159 SPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASD------------- 210

  Fly   596 SHGEDLIVTPFAQILASLRSVRNNLLSLTNVPASNKSRRPNQSSSASRSGNPPGAPLSQGEEAYT 660
            .||:|||||||||:|||||:||||..:|||:    :.|.|::.|......:...|.::  ||||.
  Rat   211 IHGDDLIVTPFAQVLASLRTVRNNFAALTNL----QDRAPSKRSPMCNQPSINKATIT--EEAYQ 269

  Fly   661 RLATDTIEELDWCLDQLETIQTHRSVSDMASLKFKRMLNKELSHFSESSRSGNQISEYICSTFLD 725
            :||::|:||||||||||||:||..|||:|||.|||||||:||:|.||.||||||:||||.:||||
  Rat   270 KLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLD 334

  Fly   726 KQQEFDLPSLRVEDNPELVAANAAAGQQSAGQYARSRSPRGPPMSQISGVKRPLSHTNSFTGERL 790
            ||.|.::|                    |..|..:.:..|  |||||||||: |.|::|.|...:
  Rat   335 KQHEVEIP--------------------SPTQKEKEKKKR--PMSQISGVKK-LMHSSSLTNSCI 376

  Fly   791 PTFGVETPRENELGTLLGELDTWGIQIFSIGEFSVNRPLTCVAYTIFQSRELLTSLMIPPKTFLN 855
            |.|||:|.:|:.|...|.:::.||:.:|.|.|.|.|||||.:.:||||.|:||.:..||..|.:.
  Rat   377 PRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLIT 441

  Fly   856 FMSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTN 920
            ::.||||||..|..:||::|||||.|||:|||:|||||.|||.||:..|:||:.||||||||::|
  Rat   442 YLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSN 506

  Fly   921 QFLVNSSSELALMYNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMS 985
            |||:|::|||||||||.||||||||||.|||||.:.||||.|:.|||||:||||.|||||:||||
  Rat   507 QFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMAIDIVLATDMS 571

  Fly   986 KHMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEE 1050
            |||:||||||||||||||..|||||||||:||||||:|:|||||||||||||.||::|...:|||
  Rat   572 KHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEE 636

  Fly  1051 FFLQGDKERESGMDISPMCDRHNATIEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEENRD 1115
            ||.|||:|||.||:||||||:|||::|||||||||||||||||||||||||||||||||||:||:
  Rat   637 FFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNRE 701

  Fly  1116 YYQSMIPPSPPPSGVDENP----QEDRIRFQVTLEESDQENLAELEEG-----DESGGESTTTGT 1171
            :|||.||.||.|:..|:..    |.::.:|::|||| |.|:..|.:.|     |.|..:|.|..|
  Rat   702 WYQSTIPQSPSPAPDDQEDGRQGQTEKFQFELTLEE-DGESDTEKDSGSQVEEDTSCSDSKTLCT 765

Fly 1172 1171
Rat 766 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDEase_I	870..1111	CDD:278654	190/240 (79%)
Pde4d	NP_001106799.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..103		34/231 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	338..358		7/41 (17%)
		PDEase_I	456..697	CDD:278654	190/240 (79%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	705..724		7/18 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	732..803		13/35 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	408	1.000	Domainoid score	I676
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H129755
Inparanoid	1	1.050	743	1.000	Inparanoid score	I559
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	1	1.000	-	-		otm44825
orthoMCL	1	0.900	-	-		OOG6_100782
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X171
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.830