DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dnc and Pde5a

DIOPT Version :9

Sequence 1:	NP_726846.1	Gene:	dnc / 31309	FlyBaseID:	FBgn0000479	Length:	1209	Species:	Drosophila melanogaster
Sequence 2:	NP_700471.2	Gene:	Pde5a / 242202	MGIID:	2651499	Length:	865	Species:	Mus musculus

Alignment Length:	905	Identity:	183/905 - (20%)
Similarity:	327/905 - (36%)	Gaps:	186/905 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   286 CQSAVQNQGQNSNPNPNQNP---NTNPNQNQQRCSCQPQTSPLPHIKEEEESDQANFKHQTSLKE 347
            |:..::...::.:.:..|:|   ||.|....::.|......||..|..::.....:|...:..||
Mouse    58 CKEGIRAHTESCSCSLQQSPHADNTTPGAPARKISASEFDRPLRPIVVKDSEGTVSFLSDSGKKE 122

  Fly   348 HQPLPPPITIATGYCGSCESVHHSSATSSSAGTVPPGGQQTQEYIAGTSSTPSPRIKLKFRKPHK 412
            ..||.|| ...:.....|..:.......||...|.....:...:|.|..|.....:.|......|
Mouse   123 QMPLTPP-RFDSDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSK 186

  Fly   413 SCW--SRIVLAPIGSAGGSSSATTVIGSNSNETLASSSTTGGTATTTQNSSSVSVAAHHRLTSSS 475
            ..:  ||:.....||         .:...||..:......|             :..|
Mouse   187 DKFLISRLFDVAEGS---------TLEEASNNCIRLEWNKG-------------IVGH------- 222

  Fly   476 ASALATSHPSN-SQLLPTSKMQAEQGSIGDLQKYHSRY-----LKNRRHTLANVRFDVENGQGAR 534
              ..|...|.| .......:..||   :..:..|.::.     :||.|..:..|...:....|
Mouse   223 --VAAFGEPLNIKDAYEDPRFNAE---VDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSG-- 280

  Fly   535 SPLEGGS-------------PSAGLVLQNLPQRRESFLYRSDSDFEMSPKSMSRNS---SIASER 583
               .||:             ...|:||.|      :.||      |.|.....||.   .:||..
Mouse   281 ---NGGTFTEKDEKDFAAYLAFCGIVLHN------AQLY------ETSLLENKRNQVLLDLASLI 330

  Fly   584 FKEQEASILVDRSHGEDLIVTPFAQILASLRSVRNNLLSLTNVPASNKSRRPNQSSSASRSGNPP 648
            |:||::.         ::|:...|..:.|...|:...:.:.:....:...|.....  ......|
Mouse   331 FEEQQSL---------EVILKKIAATIISFMQVQKCTIFIVDEDCPDSFSRVFHME--CEEVGKP 384

  Fly   649 GAPLSQGEEA------YTRLATDTIEELDWCLDQLETIQTHRSVSDMASLKFKRMLNKELSHFSE 707
            ..||::.::|      |.:...:|:|.|              ::.|:...|.....|:.:.|.:.
Mouse   385 SDPLTREQDANKINYMYAQYVKNTMEPL--------------NIPDVTKDKRFPWTNENMGHVNT 435

  Fly   708 SSRSGNQISEYICSTFLD--KQQEFDLPSL--RVEDNP-ELVAAN-------------AAAGQQS 754
            ..     |...:|:...:  |.:...:..|  ::|:|. ::.|.|             ...|.|:
Mouse   436 PC-----IGSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKIKAFNQNDEQFLEAFVIFCGLGIQN 495

  Fly   755 AGQYARSRSPRGPPMSQISGVKRPLSHTNSFTGERLPTFGV---------ETPRENEL--GTLLG 808
            ...|              ..|:|.::       :::.|..|         |..||.:.  ..::.
Mouse   496 TQMY--------------EAVERAMA-------KQMVTLEVLSYHASAAEEETRELQALSAAVVP 539

  Fly   809 ELDTWGIQIFSIGEFSVNRPLTCV-AYTIFQSRELLTSLMIPPKTFLNFMSTLEDHYVKDNPFHN 872
            ...|..|..||..:|.::...|.: ...:|....|:.:..:..:....::.:::.:|.|:..:||
Mouse   540 SAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHN 604

  Fly   873 SLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQFLVNSSSELALMYNDE 937
            ..||.:..|.....|....::...|.||....|.||..||:||.|:.|.::..|...||.:| ..
Mouse   605 WRHAFNTAQCMFAALKAGKIQNKLTDLETLALLIAALSHDLDHRGVNNSYIQRSEHPLAQLY-CH 668

  Fly   938 SVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMVETKK 1002
            |::|:||......:|.:.|..|...:...:.:|..|::...:|:||::.::....:...::...:
Mouse   669 SIMEHHHFDQCLMILNSPGNQILSGLSIDEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQ 733

  Fly  1003 VAGSGVLLLDNYTDRIQ---VLENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKER-ESGM 1063
            .         ::.|.:|   .|..|:...|||..|||.|:.:|...|:..|||.|||:|| |..|
Mouse   734 F---------SFEDPLQKELFLAMLMTACDLSAITKPWPIQQRIAELVAAEFFDQGDRERKELNM 789

  Fly  1064 DISPMCDRHNAT-IEKSQVGFIDYIVHPLWETWADLVH--PDAQDILDTLEENRDYYQSM 1120
            :.:.:.:|.... |...||||||.|...|:|.   |.|  .|...:||...:||..:|::
Mouse   790 EPADLMNREKKNKIPSMQVGFIDAICLQLYEA---LTHVSEDCLPLLDGCRKNRQKWQAL 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDEase_I	870..1111	CDD:278654	73/247 (30%)
Pde5a	NP_700471.2	GAF	154..311	CDD:214500	33/207 (16%)
		GAF	337..503	CDD:214500	28/209 (13%)
		PDEase_I	602..837	CDD:278654	73/247 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820