Protein Alignment dnc and Pde11a

DIOPT Version :9

• Sequence 1: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Sequence 2: XP_006499516.1
• Gene: Pde11a / 241489
• MGIID: 3036251
• Length: 1011
• Species: Mus musculus
• Alignment Length: 1196
• Identity: 237/1196 - (19%)
• Similarity: 403/1196 - (33%)
• Gaps: 358/1196 - (29%)

  Fly   132 LEKSAEQKRDLLERNNKE---DDLLNRTVSG----------------SELDLYG--GAGGGTKKH 175
            |::..|...|.|.|..|:   |..|.|..||                ::.:..|  |.|||....
Mouse    15 LDRHPELFEDYLMRKGKQELVDKWLQRHTSGQGASSLRPALAGASSLAQSNAKGSPGIGGGAGPQ 79

  Fly   176 SLADTIDT-----SVTTPISLKTLINDVDEELDQQLSAADIAAASLASGLVARRAEPETLSDASV 235
            ..|.:..|     |...|:|                  ...|:.|...|.:.|||..:.|..:..
Mouse    80 GSAHSHPTPGGGESAGVPLS------------------PSWASGSRGDGSLQRRASQKELRKSFA 126

  Fly   236 SPTAVVQQQQQQQQ---QLQQP--------LLQSQPHFVPSSGNILSQVTLYSGSNPSTNPCQSA 289
            ...|:...:...:|   :.|:|        ||:......|::.:|||.:.
Mouse   127 RSKAIHVNRTYDEQVTSRAQEPLSSVRRRALLRKASSLPPTTAHILSALL--------------- 176

  Fly   290 VQNQGQNSNPNPNQNPNTNPNQNQQRCSCQPQTSPLPHIKEEEE--------SDQANFKHQTSLK 346
                  .|..|..|.|   |.....:|          |:|:..|        .|.:|....|||.
Mouse   177 ------ESRVNLPQYP---PTAIDYKC----------HLKKHNERQFFLELVKDISNDLDLTSLS 222

  Fly   347 EHQPLPPPITIATGYCGSCESVHHSSATSSSAGTVPPGGQQTQ-----EYIAGTSSTP--SPRIK 404
            ....:...:.:....| |...|..::|           |::|.     :..|||...|  |....
Mouse   223 YKILIFVCLMVDADRC-SLFLVEGAAA-----------GKKTLVSKFFDVHAGTPLLPCSSTENS 275

  Fly   405 LKFRKPHKSCWSRIVLAPIGSAGGSSSATTVIG----SNSNETLASSSTTGGTATTTQNSSSVSV 465
            .:.:.|    |.:.::..:|..|.:.:......    ::..:.|....|........:||....:
Mouse   276 NEVQVP----WGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLCMPIRNSDGEII 336

  Fly   466 AAHHRLTSSSASALATSHP---------------SNSQLLPTSKMQAEQGSI------------G 503
            .....:......|..|...               ||:||...|:.:.|:...            .
Mouse   337 GVAQAINKVPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQT 401

  Fly   504 DLQKYHSRYLKNRRHTLANVRFDVENGQGARSPLEGGSPSAGLVLQNLPQRRESFLYRSDSDFE- 567
            ||:|...:.:...:..|...|..|                  |:|:::    ||.:.:....||
Mouse   402 DLEKIVKKIMHRAQTLLKCERCSV------------------LLLEDI----ESPVVKFTKSFEL 444

  Fly   568 MSPKSMSRNSSIASERFKEQEASILVDRSHGED-LIVTPFAQILASLRSVRNNLLSLTNVP--AS 629
            ||||.    |:.|...|||.     |::|...| ||....|:::||           |.:|  .|
Mouse   445 MSPKC----SADAENSFKES-----VEKSSYSDWLINNSIAELVAS-----------TGLPVNVS 489

  Fly   630 NKSRRPNQSSSASRSGNPPGAPLSQGEEAYTRLATDTIEELDWCLDQLETIQTHRSV-------S 687
            :..:.|...:.|                                 ||:..... |||       |
Mouse   490 DAYQDPRFDAEA---------------------------------DQISGFHI-RSVLCVPIWNS 520

  Fly   688 DMASLKFKRMLNK-ELSHFSESSRSGNQISEYICSTFLDKQQEFDLPSLRVEDNPELVAANAAAG 751
            :...:...::||: :...|.::.:...:.....|...::....:|
Mouse   521 NHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYD-------------------- 565

  Fly   752 QQSAGQYARSRSPRGPPMSQIS-GVKRPLSHTNSFTGERLPTFGVETPRENELGTLLGELDTWGI 815
                 |..:|.:.:...:..:| ......:..:.|....:|              |:.||   .|
Mouse   566 -----QVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIP--------------LVSEL---AI 608

  Fly   816 QIFSIGEFSVN-RPLTCVAYTIFQSRELLTSLMIPPKTFLNFMSTLEDHYVKDNPFHNSLHAADV 879
            ......:||:: ..:...|..:|....::....|..:|...::.|:..:| :...:||..||.:|
Mouse   609 DDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNY-RMVLYHNWRHAFNV 672

  Fly   880 TQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQFLVNSSSELALMYNDESVLENHH 944
            .|....:|.|...:.:.|.:|:...:.....||:||.|..|.|...|.|.||.:|...:.||:||
Mouse   673 CQLMFAMLTTAGFQEILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSDSALAQLYGTSATLEHHH 737

  Fly   945 LAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMVETKKVAGSGVL 1009
            ...|..:||::|.:||.|:..|:...|.:::...:|:||::.:.....:...:|.    .|....
Mouse   738 FNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVR----KGDYDW 798

  Fly  1010 LLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKERESGMDISP--MCDRH 1072
            .:.::.|..:.:  |:...||...|||..:.::...|:..|||.|||:|| |.:.::|  :.||:
Mouse   799 SITSHRDVFRSM--LMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRER-SELKLTPSAIFDRN 860

  Fly  1073 NA-TIEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEENRDYYQSMIPPSPPPSGVDENPQE 1136
            .. .:.:.|:.:||.|..||                         |||:......|..:.|:.:
Mouse   861 RKDELPRLQLEWIDSICMPL-------------------------YQSIGSNIRGPEFLTESTE- 899

  Fly  1137 DRIRFQVTLEESDQENLAELEEGDESGGESTTTGTTGTTAASALSGAGGG--------GGGG--- 1190
              :.|.|.|.||                 .||.|..|.:.....:|.|.|        |..|
Mouse   900 --LAFFVYLNES-----------------LTTGGWEGDSLLLFFAGLGEGQCKTETNAGFSGCQP 945

  Fly  1191 ---GGMAPR--TG-GCQNQP--QHGG 1208
               |.:||:  || ||..:|  .|||
Mouse   946 KEVGRVAPKKTTGLGCLPRPCQSHGG 971

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDEase_I	870..1111	CDD:278654	66/243 (27%)
Pde11a	XP_006499516.1	GAF	217..380	CDD:214500	28/178 (16%)
		GAF	402..568	CDD:214500	46/266 (17%)
		PDEase_I	663..885	CDD:365964	69/253 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810