Protein Alignment dnc and Pde2a

DIOPT Version :10

• Sequence 1: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Sequence 2: XP_006507586.1
• Gene: Pde2a / 207728
• MGIID: 2446107
• Length: 953
• Species: Mus musculus
• Alignment Length: 843
• Identity: 188/843 - (22%)
• Similarity: 311/843 - (36%)
• Gaps: 231/843 - (27%)

  Fly   452 GTATTTQNSSSVSVAAHHRLTSSSASALATSHPSNSQ--LLPTSKMQAEQGSIGDLQKYHSRYLK 514
            |..:.::..|...|..|..:......||....|...|  .:..|:.|.::....|    |.|.:.
Mouse   183 GQLSDSEEQSLQVVEKHALVALRRVQALQQRRPEAVQNTSVDASEDQKDEKGYTD----HDRKIL 243

  Fly   515 NRRHTLANVRFDVENGQGARSPLEGGSPSAGL-VLQNLPQRRES----FLYRSDSDFEMSPKSMS 574
            .    |....||::            :.|..| |||.|.|..::    .|..|:.:.::|.|
Mouse   244 Q----LCGELFDLD------------ATSLQLKVLQYLQQETQATHCCLLLVSEDNLQLSCK--- 289

  Fly   575 RNSSIASERFKEQEASILVDRSHGED----LIVTPFAQILASLRSVR------------NNLL-- 621
                            ::.|:..||:    |.:....|::...:.::            .|:|
Mouse   290 ----------------VIGDKVLGEEVSFPLTMGRLGQVVEDKQCIQLKDLTSDDVQQLQNMLGC 338

  Fly   622 ---SLTNVPASNKSRRPNQSSSASRSGNPPGAPLSQGEEAYTRLATDTIEELDWCLDQLETIQTH 683
               ::..||..  ||..:|..:.:.:.|..|......|:.:.         :..|.....|:.|
Mouse   339 ELQAMLCVPVI--SRATDQVVALACAFNKLGGDFFTDEDEHV---------IQHCFHYTGTVLT- 391

  Fly   684 RSVSDMASLKFKRM---------LNKEL-SHFSESS--------RSGNQISEYICSTFLDKQQE- 729
               |.:|..|.:::         :.|.| :|..:.|        .:.|..:..|||.||..|.|
Mouse   392 ---STLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNEL 453

  Fly   730 ----FDLPSLRVEDNPELVAANAAAGQQSAGQYARSRSPRGPPMSQISGVKRPLSH--------- 781
                ||  ...|:|  |.......|.|..||..|.:        .||..:....:|
Mouse   454 VAKVFD--GGVVDD--ESYEIRIPADQGIAGHVATT--------GQILNIPDAYAHPLFYRGVDD 506

  Fly   782 TNSFTGERLPTFGVETPRENELGT--LLGELD-TW----------------GIQIF------SIG 821
            :..|....:..|.::...:..:|.  |:.::: .|                ||.|.      .:.
Mouse   507 STGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVN 571

  Fly   822 EFSVNRPLT--CVAYTIFQSRELLTSLM---IPP-----KTFLNF----------------MSTL 860
            |......|.  .:.|.:..|.:..|.|:   |.|     ..|.||                :|.|
Mouse   572 EAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFANFTYTPRSLPEDDTSMAILSML 636

  Fly   861 ED-----HY-----------------VKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGG 903
            :|     :|                 .:|.|:||.:||..|:....:|.....|......:|: .
Mouse   637 QDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELSNYLEDIEI-F 700

  Fly   904 ALFAACI-HDVDHPGLTNQFLVNSSSELALMYNDE-SVLENHHLAVAFKLLQNQGCDIFCNMQKK 966
            |||.:|: ||:||.|..|.|.|.|.|.||.:|:.| ||:|.||.|.|..:|...||:||.:..:|
Mouse   701 ALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRK 765

  Fly   967 QRQTLRKMVIDIVLSTDMSKHMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLENLVHC---- 1027
            ..|.:..::.||:|:||::.|:.:..||:.|.|.            .|....:....|:.|
Mouse   766 DYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEV------------GYDRNNRQHHRLLLCLLMT 818

  Fly  1028 -ADLSNPTKPLPLYKRWVALLMEEFFLQGDKERESGMDISPMCDRHNATIEKSQVGFIDYIVHPL 1091
             .|||:.||.....::...|:.:|||.|||.|:..|.....|.||..|.|.:.|:.|:::|..|:
Mouse   819 SCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPI 883

  Fly  1092 WETWADLVHPDAQDILDTLEENRDYYQSM-----IPPSPPPSGVD------ENPQEDRIRFQV 1143
            ::...|| .|.|.::.:.:..||:::..:     |...|..:.:|      |.|..|..|..|
Mouse   884 YKLLQDL-FPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPV 945

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDE4_UCR	603..725	CDD:465648	26/156 (17%)
		PDEase_I	870..1110	CDD:459723	80/246 (33%)
Pde2a	XP_006507586.1	GAF	253..400	CDD:214500	32/192 (17%)
		GAF	422..571	CDD:214500	30/160 (19%)
		PDEase_I	668..901	CDD:459723	80/246 (33%)