DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dnc and Pde9a

DIOPT Version :9

Sequence 1:	NP_726846.1	Gene:	dnc / 31309	FlyBaseID:	FBgn0000479	Length:	1209	Species:	Drosophila melanogaster
Sequence 2:	NP_612552.1	Gene:	Pde9a / 191569	RGDID:	621035	Length:	534	Species:	Rattus norvegicus

Alignment Length:	491	Identity:	125/491 - (25%)
Similarity:	228/491 - (46%)	Gaps:	67/491 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   684 RSVSDMASLKFKRMLNKELSHFSESSRSGNQISEYICSTFLDKQQEFDLPSLRVEDNPELVAANA 748
            :.||:...| .:.:|.:....||.:.:. |::...:.:.....::..:|..|:|.:..:..:...
  Rat    84 KQVSEREEL-VQGVLAQVAEQFSRAFKI-NELKAEVANHLAMLEKRVELEGLKVVEIEKCKSDIK 146

  Fly   749 AAGQQSAGQYARSRSP---------RGPPMSQISGVKRPLSHTNSFTGERLPTFGVETPRENELG 804
            ...::.|.:..|:..|         :..|...:....:.|....:....|.|||.|.....||:.
  Rat   147 KMREELAARNNRTNCPCKYSFLDNKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEML 211

  Fly   805 TLLGEL--DTWGIQIFSIGEFSVNRPLTCVAYTIFQSRELLTSLMIPPKTFLNFMSTLEDHYVKD 867
            :.|..:  |...::.|||...::.|.|.||                            .|:| :.
  Rat   212 SCLEHMYHDLGLVRDFSINPITLRRWLLCV----------------------------HDNY-RS 247

  Fly   868 NPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQFLVNSSSELAL 932
            |||||..|...|||....::....|:..|:.:::...:.||..||:||||..|.:.:|:.:|||:
  Rat   248 NPFHNFRHCFCVTQMMYSMVWLCGLQEKFSQMDILVLMTAAICHDLDHPGYNNTYQINARTELAV 312

  Fly   933 MYNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTM 997
            .|||.|.|||||.|:||::|....|:||.::..:..:.:|:.:|.::|:|||::|..::...|..
  Rat   313 RYNDISPLENHHCAIAFQILARPECNIFASVPPEGFRQIRQGMITLILATDMARHAEIMDSFKEK 377

  Fly   998 VETKKVAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKERESG 1062
            :|....:....|.|      ::::  |:.|.|:||..:|:.:.:.||..|:||:|:|.|:|:..|
  Rat   378 MENFDYSNEEHLTL------LKMI--LIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEG 434

  Fly  1063 MDISPMCDRHNATIEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEENRDYYQSMIPPSPP- 1126
            :.::|..||...|...:|:|||.:::.|::||...|.....:.:|..|.|:|::|:.:......
  Rat   435 LPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPIVEETMLRPLWESREHYEELKQLDDAM 499

  Fly  1127 ----------PSGVDENPQEDRIRFQVTLEESDQEN 1152
                      .||..||..|.      |.:..|.|:
  Rat   500 KELQKKTENLTSGATENAPEK------TRDAKDNED 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDEase_I	870..1111	CDD:278654	78/240 (33%)
Pde9a	NP_612552.1	PDEase_I	250..478	CDD:278654	77/235 (33%)
Pde9a	NP_612552.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..534		8/36 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820