Protein Alignment dnc and Pde9a

DIOPT Version :10

• Sequence 1: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Sequence 2: XP_036016291.1
• Gene: Pde9a / 18585
• MGIID: 1277179
• Length: 536
• Species: Mus musculus
• Alignment Length: 551
• Identity: 142/551 - (25%)
• Similarity: 256/551 - (46%)
• Gaps: 91/551 - (16%)

  Fly   617 RNNLLSLTNVPASNKSRRPNQSSSASRSGNP----PGA--PLSQGEEAYTRLATDTIEELD--WC 673
            ||..:||.....:..|..|...:::.|:  |    |.|  .:|:.||....:.....|:..  :.
Mouse    47 RNTTISLLTTDDAMVSIDPTMPANSERT--PYKVRPVAVKQVSEREELIQGVLAQVAEQFSRAFK 109

  Fly   674 LDQLET-IQTHRSVSDMASLKFKRMLNKELSHFSESSRSGNQISEY-ICSTFLDKQQEFDLPSLR 736
            :::|:. :..|.:|.:      ||:   ||        .|.::.|. .|.:.:.|.:|
Mouse   110 INELKAEVANHLAVLE------KRV---EL--------EGLKVVEIEKCKSDIKKMRE------- 150

  Fly   737 VEDNPELVAANAAAGQQSAGQYARSRSPRGPPMSQISGVKRPLSHTNSFTGERLPTFGVETPREN 801
                 ||.|.|:..  ....:|:...:.:..|...:....:.|....:....|.|||.|.....|
Mouse   151 -----ELAARNSRT--NCPCKYSFLDNKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPN 208

  Fly   802 ELGTLLGEL--DTWGIQIFSIGEFSVNRPLTCVAYTIFQSRELLTSLMIPPKTFLNFMSTLEDHY 864
            |:.:.|..:  |...::.|||...::.|.|.||                            .|:|
Mouse   209 EMLSCLEHMYHDLGLVRDFSINPITLRRWLLCV----------------------------HDNY 245

  Fly   865 VKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQFLVNSSSE 929
             ::|||||..|...|||....::....|:..|:.:::...:.||..||:||||..|.:.:|:.:|
Mouse   246 -RNNPFHNFRHCFCVTQMMYSMVWLCGLQEKFSQMDILVLMTAAICHDLDHPGYNNTYQINARTE 309

  Fly   930 LALMYNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADL 994
            ||:.|||.|.|||||.|:||::|....|:||.::..:..:.:|:.:|.::|:|||::|..::...
Mouse   310 LAVRYNDISPLENHHCAIAFQILARPECNIFASVPPEGFRQIRQGMITLILATDMARHAEIMDSF 374

  Fly   995 KTMVETKKVAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKER 1059
            |..:|....:....|.|      ::::  |:.|.|:||..:|:.:.:.||..|:||:|:|.|:|:
Mouse   375 KEKMENFDYSNEEHLTL------LKMI--LIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREK 431

  Fly  1060 ESGMDISPMCDRHNATIEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEENRDYYQSMIPPS 1124
            ..|:.::|..||...|...:|:|||.:::.|::||...|.....:.:|..|.|:|::|:.:
Mouse   432 SEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPVVEETMLRPLWESREHYEEL---- 492

  Fly  1125 PPPSGVDENPQEDRI--RFQVTLEESDQENL 1153
               ..:|:..:|.:.  |.|...||..:.|:
Mouse   493 ---KQLDDAMKEVKAVQRVQAVAEEDRELNI 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDE4_UCR	603..725	CDD:465648	24/117 (21%)
		PDEase_I	870..1110	CDD:459723	78/239 (33%)
Pde9a	XP_036016291.1	PDEase_I	250..478	CDD:459723	77/235 (33%)