Protein Alignment dnc and Pde3b

DIOPT Version :10

• Sequence 1: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Sequence 2: NP_035185.2
• Gene: Pde3b / 18576
• MGIID: 1333863
• Length: 1099
• Species: Mus musculus
• Alignment Length: 900
• Identity: 202/900 - (22%)
• Similarity: 311/900 - (34%)
• Gaps: 322/900 - (35%)

  Fly   351 LPPPI--------TIATGYCGSCESVHHSSA-------TSSSAGTVPPGGQQTQEYIAGTSSTPS 400
            |||.:        ::...:.|||....:|..       .|.....|..|.::..:.::|.:|.|:
Mouse   350 LPPQVISSLRSISSLMGAFSGSCRPKINSFTPFPGFYPCSEVEDPVEKGDRKLHKGLSGRTSFPT 414

  Fly   401 PRIKLK------FRKPHKSCWSRIVLAPIGSAGGSSSATTVIGSNS---NETLASSSTTGGTATT 456
            |:::..      ....|.|.|.|       |:|..|.....:.|:.   |...:|:..|    ..
Mouse   415 PQLRRSSGASSLLTNEHCSRWDR-------SSGKRSYQELSVSSHGCHLNGPFSSNLFT----IP 468

  Fly   457 TQNSSSVSVAAHHRLTSSSASALATSHPSNSQLLPTSKMQAEQGSIGDLQKYHSRYLKNRRHTLA 521
            .|.|||||:..|..|..:.|.      ||:|.|..:|.:....||:.:
Mouse   469 KQRSSSVSLTHHAGLRRAGAL------PSHSLLNSSSHVPVSAGSLTN----------------- 510

  Fly   522 NVRFDVENGQGARSPLEGGSPSAGLVLQNLPQRRESFLYRSDSDFEMSPKSMSRNSSIASERFKE 586
                        |||:  |.|..                   :||...|
Mouse   511 ------------RSPI--GFPDT-------------------TDFLTKP---------------- 526

  Fly   587 QEASILVDRSHGEDLIVTPFAQILASLRSVRNNLLS----------LTNVP--ASNKSRRPNQSS 639
               :|::.||.|.   |:..|.....||:..:||.|          .|..|  ..:.|.:..:..
Mouse   527 ---NIILHRSLGS---VSSAADFHQYLRNSDSNLCSSCGHQILKYVSTCEPDGTDHPSEKSGEED 585

  Fly   640 SASRSGNPPGAPLSQGEEAYTRLATDTIEELDWCLDQLETIQTHRSVSDMASLKFKRMLNKELSH 704
            |:..|..|.....:|.||...:...:...|.|                               ||
Mouse   586 SSVFSKEPLNIVETQEEETMKKACRELFLEGD-------------------------------SH 619

  Fly   705 FSESSRSGNQISEYICSTFLDKQQEFDLPSLRVEDNPELVAANAAAGQQSAGQYARSRSPRGPPM 769
            ..|.::..|          :|  ||..|..:.|||
Mouse   620 LMEEAQQPN----------ID--QEVSLDPMLVED------------------------------ 642

  Fly   770 SQISGVKRPLSHTNSFTGERLPTFGVETPRENELGTLLGELDTWGIQIFSI----GEFSVNRPLT 830
                                             ..:|:.:::.|..|||.:    ||.| .|.|:
Mouse   643 ---------------------------------YDSLIEKMNNWNFQIFELVEKMGEKS-GRILS 673

  Fly   831 CVAYTIFQSRELLTSLMIPPKTFLNFMSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTP----- 890
            .|.||:||...||.:..||.:.|:|:...||:.| :|.|:||.:||.||..:...|...|
Mouse   674 QVMYTLFQDTGLLETFKIPTQEFMNYFRALENGY-RDIPYHNRVHATDVLHAVWYLTTRPIPGLP 737

  Fly   891 ---------------------------------------ALEGVFTPLEVGGALFAACIHDVDHP 916
                                                   .|......||:.....||.:||.|||
Mouse   738 QIHNNHETETKADSDGRLGSGQIAYISSKSCCIPDMSYGCLSSNIPALELMALYVAAAMHDYDHP 802

  Fly   917 GLTNQFLVNSSSELALMYNDESVLENHHLAVAFKL-LQNQGCDIFCNMQKKQRQTLRKMVIDIVL 980
            |.||.|||.:::..|::|||.|||||||.|.|:.| |.....:...|:...:.:..|.:||:.:|
Mouse   803 GRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLNLDHMEFKRFRFLVIEAIL 867

  Fly   981 STDMSKHMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVA 1045
            :||:.||...||:..  .:...|..:|: ...:..||:.|.:..:..||::.|.|...|:.||..
Mouse   868 ATDLKKHFDFLAEFN--AKANDVNSNGI-EWSSENDRLLVCQVCIKLADINGPAKDRDLHLRWTE 929

  Fly  1046 LLMEEFFLQGDKERESGMDISPMCDRHNATIEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTL 1110
            .::.||:.|||:|...|:.|||..||.:..:.|.|..||.:||.||..::      ||..:|
Mouse   930 GIVNEFYEQGDEEATLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSY------DAAGLL--- 985

  Fly  1111 EENRDYYQSMIPPSPPPSGVDENPQEDRIRFQVTLEESDQENLAELEEGDESGGE 1165
                           |...::....:|        .|||.:     ::.|:.|||
Mouse   986 ---------------PGQWIETEEGDD--------TESDDD-----DDDDDGGGE 1012

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDE4_UCR	603..725	CDD:465648	22/133 (17%)
		PDEase_I	870..1110	CDD:459723	85/284 (30%)
Pde3b	NP_035185.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29
		Interaction with RAPGEF3. /evidence=ECO:0000250|UniProtKB:Q13370	1..28
		CynX	<119..260	CDD:442057
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	400..423		4/22 (18%)
		Interaction with PIK3R6. /evidence=ECO:0000250|UniProtKB:Q13370	415..439		5/30 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	570..590		3/19 (16%)
		PDEase_I	712..986	CDD:459723	85/300 (28%)