DRSC/TRiP Functional Genomics Resources

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Protein Alignment dnc and Pde1a

DIOPT Version :10

Sequence 1:NP_726846.1 Gene:dnc / 31309 FlyBaseID:FBgn0000479 Length:1209 Species:Drosophila melanogaster
Sequence 2:NP_058024.2 Gene:Pde1a / 18573 MGIID:1201792 Length:545 Species:Mus musculus


Alignment Length:491 Identity:153/491 - (31%)
Similarity:246/491 - (50%) Gaps:88/491 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   663 ATDT-IEELD---------------W--------CL-DQLE-----TIQTHRSVSDMASL----- 692
            :||| ||||:               |        || .|||     .:...:::...||:     
Mouse     3 STDTDIEELENATYKYLIGEQTEKMWQRLKGILRCLVKQLEKGDVNVVDLKKNIEYAASVLEAVY 67

  Fly   693 --KFKRMLN--KELSHFSESSRSGNQISEYICSTFLDKQQEFDLPSLRVEDNPELVAANAAAGQQ 753
              :.:|:|:  .|||.....| ..:::.:::.|||..|   ..:...:.|:.|:..:...|.   
Mouse    68 IDETRRLLDTEDELSDIQTDS-VPSEVRDWLASTFTRK---MGMMKKKPEEKPKFRSIVHAV--- 125

  Fly   754 SAGQYARSRSPRGPPMSQISGVKRPLSHTNSFTGERLPTFGVETPRENELGTLLGELDTWGIQIF 818
            .||.:                |:|.........|...|...:.|         |.|:|.|...:|
Mouse   126 QAGIF----------------VERMYRKNYHMVGLTYPAAVIVT---------LKEVDKWSFDVF 165

  Fly   819 SIGEFSVNRPLTCVAYTIFQSRELLTSLMIPPKTFLNFMSTLEDHYVK-DNPFHNSLHAADVTQS 882
            ::.|.|....|..:.|.:|...:|:....||....:.|...||..|.| .||:||.:|||||||:
Mouse   166 ALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLIAFAEALEVGYSKHKNPYHNLVHAADVTQT 230

  Fly   883 TN-VLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLA 946
            .: ::|:|..:..: |.||:...:|||.|||.:|.|.||.|.:.:.|::|::|||.|||||||::
Mouse   231 VHYIMLHTGIMHWL-TELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVS 294

  Fly   947 VAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMVETKKVAGSGVLLL 1011
            .|::|:|.:..:|..|:.|...:.||.:||::||:||||.|...:.:::..::..:    |:   
Mouse   295 AAYRLMQEEEMNILVNLSKDDWRDLRNLVIEMVLATDMSGHFQQIKNIRNSLQQPE----GI--- 352

  Fly  1012 DNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKERESGMDISPMCDRHNATI 1076
                ||.:.:..::|.||:|:|.|...|:.||...||||||||||||.|.|:..||:|||.:..:
Mouse   353 ----DRAKTMSLILHAADISHPAKTWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMV 413

  Fly  1077 EKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEE 1112
            .:||:||||:||.|   |::.|.....:.::..:||
Mouse   414 AQSQIGFIDFIVEP---TFSLLTDSTEKIVIPLIEE 446

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dncNP_726846.1 PDE4_UCR 603..725 CDD:465648 24/100 (24%)
PDEase_I 870..1110 CDD:459723 96/240 (40%)
Pde1aNP_058024.2 Calmodulin-binding. /evidence=ECO:0000250|UniProtKB:P14100 24..44 5/19 (26%)
PDEase_I_N 73..133 CDD:462497 16/82 (20%)
Calmodulin-binding. /evidence=ECO:0000250|UniProtKB:P14100 114..137 6/41 (15%)
PDEase_I 218..439 CDD:459723 96/235 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 526..545
Blue background indicates that the domain is not in the aligned region.

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