DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dnc and pde-5

DIOPT Version :9

Sequence 1:NP_726846.1 Gene:dnc / 31309 FlyBaseID:FBgn0000479 Length:1209 Species:Drosophila melanogaster
Sequence 2:NP_491544.3 Gene:pde-5 / 183125 WormBaseID:WBGene00016328 Length:728 Species:Caenorhabditis elegans


Alignment Length:830 Identity:180/830 - (21%)
Similarity:302/830 - (36%) Gaps:218/830 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   394 GTSSTPSPRIKLKFRKPHKSCWSRI-VLAPIGSAGGSSSATTVIGSNSNETL------------- 444
            ||.:...|.:.:|.|...::..:|. :|..|....|.     :||:||.|.:             
 Worm    52 GTGAWTEPDLSMKRRVILETSDNRTRILYEITQCCGQ-----LIGTNSIELIVQNDEGAFSCRKT 111

  Fly   445 ---------ASSSTTGGTATTTQNSSSVSVAAHH---RLTSSSAS--------ALATSHPSNSQL 489
                     ..:|.:.....|..|:.:.::|..|   :|.|:..|        |.||::.|.   
 Worm   112 ENGELKLKKVKTSKSADYIQTIVNAGNQTIAEIHFYTQLDSTEKSIVNAVCTWAAATNYYSE--- 173

  Fly   490 LPTSKMQAEQGSIGDLQKYHSRYLKNRRHTLANVRFDVENGQGARSPLEGGSPSAGLVL------ 548
            |.|.|.:...|     |..|....|.|:  |:|...||     |||..........:::      
 Worm   174 LYTHKQEGSDG-----QDIHENIAKQRK--LSNFLLDV-----ARSIFHDIVSMDAVIIKVMNFA 226

  Fly   549 QNLPQRRESFLYRSDSDFEMSPKSMSRNSSIASERF-------------KEQEASILVDRSHGED 600
            |.|.....:.|:..|          |:|:.|.:..|             .|.:..|..|.|.|  
 Worm   227 QKLVDADRASLFLVD----------SKNAQIYARIFDVGTGDEEHVRVNSEGQKEIRFDMSKG-- 279

  Fly   601 LIVTPFAQILASLRSVRNNLLSLTNVPASNKSRRPNQSSSASRSGNPPGAPLSQGEEAYTRLATD 665
                    |...:.|....|    |:..:.:..|.| :...|::|             ||   |.
 Worm   280 --------IAGYVASTGEGL----NIENAYEDERFN-ADVDSKTG-------------YT---TK 315

  Fly   666 TIEELDWCLDQLETIQTHRSVSDMASLKFKRMLNKELSHFSESSRSGNQISEYICSTFLDKQQEF 730
            ||    .|:..|     .|.:    .:...:|:||....|:.......:|....|...|...:.:
 Worm   316 TI----LCMPIL-----IRGI----VIGVVQMVNKHDGVFTRQDEDAFEIFAVYCGLALHHAKLY 367

  Fly   731 DLPSLRVEDNPELVAANAAAGQQSAGQYARSRSPRGPPMSQISGVKRPLSHTNSFTGERLPTFGV 795
            |  .:|..:....||....|                             .|:.....|      |
 Worm   368 D--KIRRSEQKYRVALEVLA-----------------------------YHSVCNADE------V 395

  Fly   796 ETPRENELGTLLGELDTWGIQIFSIGEFSVNRPLTCVAYTIFQSRELLT-SLMIPPKTFLNFMST 859
            ...::.|:...:.||:|.......:.|  :.:||    |.::..:.|.. :|....:..:.|:.|
 Worm   396 NKLKKIEINNRIVELETIDFNGMRLSE--LEKPL----YAVYMFKTLFADTLRFDTEDLIRFVLT 454

  Fly   860 LEDHYVKDNPFHNSLHAADVTQST-NVLLNTPALEGVFTPLEVGGALFAACI-HDVDHPGLTNQF 922
            :..:| :...:||..|...|..:. ..|:|:|   ..||.|| ..||:.:|: ||:||.|..|.:
 Worm   455 VRKNY-RRVAYHNWAHGWSVAHAMFATLMNSP---DAFTKLE-ALALYVSCLCHDLDHRGKNNAY 514

  Fly   923 LVNSSSELALMYNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKH 987
            :...|:.||.:|: .||:|.||......:||..|.:|..::..:..:....::...:|:||::..
 Worm   515 MKTMSTPLASIYS-TSVMERHHFNQTVTILQQDGHNILKSLSSEDYKKTLSLIKHCILATDLALF 578

  Fly   988 MSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLEN--------LVHCADLSNPTKPLPLYKRWV 1044
            .|..|.|.             ::|||.|..|...|:        :..| ||....||..:....|
 Worm   579 FSNKAKLN-------------VILDNNTFDINRQEHRLLTQAVMMTGC-DLVASAKPWNIQTETV 629

  Fly  1045 ALLMEEFFLQGDKERESGMDISPMCDRHNA-TIEKSQVGFIDYIVHPLWETWADLVHPDAQDILD 1108
            .::.|||:.|||.||.||.:..||.||..| .:.:.||||:..|..|.::..| .:.|....:.:
 Worm   630 KVIFEEFYDQGDAERLSGKEPIPMMDRQQAHMLPQMQVGFMRGICMPCYDLIA-RIFPKNDKMRE 693

  Fly  1109 TLEENRDYYQSMIPPSPPPSGVDENPQEDRIRFQVTLEESDQENLAELEE 1158
            ..|.|...:             :|..:|.|.:.:...:::.:.|  |.:|
 Worm   694 RCEYNAKKW-------------EELAEEQRKKQEALAQQNGEAN--ETQE 728

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dncNP_726846.1 PDEase_I 870..1111 CDD:278654 74/251 (29%)
pde-5NP_491544.3 GAF 221..371 CDD:214500 37/205 (18%)
PDEase_I 464..696 CDD:278654 74/251 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3689
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D904682at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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