DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dnc and pde-2

DIOPT Version :9

Sequence 1:	NP_726846.1	Gene:	dnc / 31309	FlyBaseID:	FBgn0000479	Length:	1209	Species:	Drosophila melanogaster
Sequence 2:	NP_001022705.2	Gene:	pde-2 / 176270	WormBaseID:	WBGene00011146	Length:	831	Species:	Caenorhabditis elegans

Alignment Length:	781	Identity:	169/781 - (21%)
Similarity:	291/781 - (37%)	Gaps:	195/781 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   441 NETLASSSTTGG-TATTTQNSSSVSVAAHHRLTSSSASALA---TSHPS---NSQLLPTSKMQAE 498
            :|..:.|:..|| |..|..|::..|     ...:.|||...   ||||.   |:.......:|.:
Worm    35 HEAASGSTCCGGMTVFTGANAAKSS-----NEPAGSASPTVWRKTSHPPLHFNNNETRNRNLQMQ 94

  Fly   499 QGSIGDLQKYHSRYLKNR---RHTLANVRFDVENGQGARSPLEGGSPSAGLVLQNLPQRRESFLY 560
                          ||||   ....|::|:|:|            .|::..:|:.||.
Worm    95 --------------LKNRGTKDDWGASLRYDIE------------EPTSSGLLELLPD------- 126

  Fly   561 RSDSDFEMSPKSMSRNSSIASERFKEQEASILVDRSHGEDLIVTP------FAQILASLRSVRNN 619
                      ..:.|..|....:..:|:.:..|..:..:..:::|      |.|.|.    :.||
Worm   127 ----------VPIVRKLSRPLVKMDDQDDACSVASNESDRTVLSPLVPMSIFDQFLC----LTNN 177

  Fly   620 LLSLTN--VPASNKSRRPNQSSSASRSGNPPGAPLSQGEEAYTRLATDTIEELDW-CLDQLETIQ 681
            |.:|.:  :..:.|:......:......:.....|...|   |.|.|....::.: .:.::.:..
Worm   178 LSALISCIIAEAKKNTEAEDYAVFLHDEDNKQMVLFNNE---TMLMTGKKFDMGYGIVGKVASTM 239

  Fly   682 THRSVSDMASLKFKRMLNKEL-SHFSESSRSGNQIS----EYICS-----TFLDKQQEFDLPSLR 736
            ...::.|::...|   .|:|: ..||..:|  |.|:    :..||     ...:|:..|.....:
Worm   240 RTMNIRDVSRCPF---FNEEIDEQFSIKAR--NLIAFPLIDSSCSLIGVIVLYNKENGFSRHDEK 299

  Fly   737 VEDNPELVAANAAAGQQSAGQYARSRSPRGPPMSQISGVKRPLSHTNSF--TGERLPTFGVETPR 799
            .........||:.|....|              .||..|:..:.....|  .||
Worm   300 YIKRFSYFVANSIAHAILA--------------KQIEEVRTRIHMVEEFKIQGE----------- 339

  Fly   800 ENELGTLLGELDTWGIQIFSIGEFSVNRPLTCVAYTIFQSRELLTSLMIPPKTFLNFMSTLEDHY 864
                ..::.|:|...:         ||.||....|  |...  ......||:      |..|:|:
Worm   340 ----DAVIEEVDIMRL---------VNDPLRDWRY--FSQN--FADFSFPPR------SVGENHF 381

  Fly   865 VKDN----------------------------------PFHNSLHAADVTQSTNVLLNTPALEGV 895
            .:.:                                  |:||..||..||....:.|.|.|:...
Worm   382 HRASMMFFEDLGFSMLYKLNKRKLSYLVLRVSAGYRPVPYHNWSHAFAVTHFCWLTLRTDAIRRA 446

  Fly   896 FTPLEVGGALFAACIHDVDHPGLTNQFLVNS--SSELALMYNDE-SVLENHHLAVAFKLLQNQGC 957
            .:.:|....|.|...||:||.|.||.|.:.|  .:.|:::|:.| ||||.||.|...||||.:.|
Worm   447 LSDMERLSLLIACLCHDIDHRGTTNSFQMQSLQKTPLSVLYSTEGSVLERHHFAQTIKLLQQEEC 511

  Fly   958 DIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLE 1022
            .|..|:.....:|:...:.:::|:||:|.|:.....:|||:.    .|...:..|:   |..::.
Worm   512 SILENLPAADFRTIVNTIREVILATDISAHLRKQERIKTMIS----EGYNPMSFDH---RYLLMC 569

  Fly  1023 NLVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKERESGMDISPMCDRHNATIEKSQVGFIDYI 1087
            .::..:|||:..|.....||....:..|||.|||.|.:.|:....|.||.||.:...|:.|:..|
Worm   570 LVMTASDLSDQAKNFHNAKRIAENIYLEFFAQGDLELQLGVKPLEMMDRTNAYVPTVQIDFLFKI 634

  Fly  1088 VHPLWETWADLVHPDAQDILDTLEENRDYYQSM---IPPSPPPSGV-----DENPQE---DRIRF 1141
            ..|:::..|.:| |:.:...:.::.|...:.::   :..:|..:..     |||.:.   ||:|.
Worm   635 GVPVFQLLASVV-PEGRTTSEAIDANHLCWVALDEEVRNNPSATNTLEYLRDENLERRIYDRVRK 698

  Fly  1142 Q 1142
            |
Worm   699 Q 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDEase_I	870..1111	CDD:278654	76/243 (31%)
pde-2	NP_001022705.2	GAF	177..322	CDD:214500	27/166 (16%)
pde-2	NP_001022705.2	PDEase_I	421..657	CDD:278654	76/243 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920