DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dnc and pde-4

DIOPT Version :9

Sequence 1:	NP_726846.1	Gene:	dnc / 31309	FlyBaseID:	FBgn0000479	Length:	1209	Species:	Drosophila melanogaster
Sequence 2:	NP_871945.1	Gene:	pde-4 / 174235	WormBaseID:	WBGene00020114	Length:	674	Species:	Caenorhabditis elegans

Alignment Length:	720	Identity:	345/720 - (47%)
Similarity:	460/720 - (63%)	Gaps:	59/720 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   437 GSNSNETLASSSTTGGTATTTQNSSSVSVAAHHRLTSSSASALATSHPSNSQLLPTSKMQAEQGS 501
            ||:|:.:.|..|  ||......:|....:..|:...:||.||.:||....:.|.|.:......||
Worm     6 GSSSSSSAAGGS--GGGGGFGFSSLRRELHLHNFFRTSSPSASSTSRTPPAALPPRTSAVTIPGS 68

  Fly   502 IGDLQKYHSRYLKNRRHTLANVRFDVENGQGARSPLEGGSPSAGLVLQNLPQRRESFLYRSDSDF 566
            ...|....|.|...|..|::.    ...|....:...||:.....:..::..||||||||:..|.
Worm    69 NHKLTSSASSYHPPRELTVST----FSAGSATAADGLGGAHLTPSLSSSVHARRESFLYRASDDL 129

  Fly   567 E--MSPKSMSRNSSIASERFKEQEASILVDRSHGEDLIVTPFAQILASLRSVRNNLLSLTNVPAS 629
            .  .|.:.:||.|||||.           :..||:|||||||||:|||||:||:||:|:||:..|
Worm   130 REASSLRPVSRASSIASN-----------EHGHGDDLIVTPFAQLLASLRNVRSNLISITNIQNS 183

  Fly   630 NKSRRPNQSSSASRSGNPPGAPLSQGEEAYTRLATDTIEELDWCLDQLETIQTHRSVSDMASLKF 694
            :.||..|:|:.     .||...:...::. ...|.||:||||||||||||||||||||:|||.||
Worm   184 DDSRHANRSAK-----RPPLHNIELPDDV-VHCAHDTLEELDWCLDQLETIQTHRSVSEMASSKF 242

  Fly   695 KRMLNKELSHFSESSRSGNQISEYICSTFLDKQQEFDLPSLRVEDNPELVAANAAAGQQSAGQYA 759
            ::|||||||||:|||:||.|:|:::.:|::||::  |.||:.:|...|:      .|..::|...
Worm   243 RKMLNKELSHFAESSKSGTQVSKFLITTYMDKEE--DEPSIEIEVPTEV------QGPSTSGPMT 299

  Fly   760 RS--RSPRGPPMSQISGVK--RPLSHTNSFTGERLPTFGVETPRENELGTLLGELDTWGIQIFSI 820
            .|  :..:...|::||||:  |..||..     .:|.:||...|  |:...:..||.||..:|.|
Worm   300 LSILKKAQTAAMNKISGVRKLRAPSHDG-----HVPEYGVNCAR--EIAVHMQRLDDWGPDVFKI 357

  Fly   821 GEFSVNRPLTCVAYTIFQSRELLTSLMIPPKTFLNFMSTLEDHYVKDNPFHNSLHAADVTQSTNV 885
            .|.|.|..||.|.:::.:.|.|..:..|...|.:.::..||.|| ::|.:||.:|||||.||.:|
Worm   358 DELSKNHSLTVVTFSLLRQRNLFKTFEIHQSTLVTYLLNLEHHY-RNNHYHNFIHAADVAQSMHV 421

  Fly   886 LLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFK 950
            ||.:|.|..|||.|||..|:||..:|||||||.|||:|:||::|||:|||||||||.||||||||
Worm   422 LLMSPVLTEVFTDLEVLAAIFAGAVHDVDHPGFTNQYLINSNNELAIMYNDESVLEQHHLAVAFK 486

  Fly   951 LLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMVETKKVAGSGVLLLDNYT 1015
            |||:..||...|:.:|||...||:|||:||:||||||||||||||||||.|||||:.|::||.|.
Worm   487 LLQDSNCDFLANLSRKQRLQFRKIVIDMVLATDMSKHMSLLADLKTMVEAKKVAGNNVIVLDKYN 551

  Fly  1016 DRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKERESGMDISPMCDRHNATIEKSQ 1080
            |:||||::::|.|||||||||:.||::|...:|||::.|||||:|.|::|||||||.|.||||||
Worm   552 DKIQVLQSMIHLADLSNPTKPIELYQQWNQRIMEEYWRQGDKEKELGLEISPMCDRGNVTIEKSQ 616

  Fly  1081 VGFIDYIVHPLWETWADLVHPDAQDILDTLEENRDYYQSMIPPSPPPSGVDENPQEDRIRFQVTL 1145
            |||||||||||:|||||||:||||:|||.|||||::|||.||..|           |..|   |:
Worm   617 VGFIDYIVHPLYETWADLVYPDAQNILDQLEENREWYQSRIPEEP-----------DTAR---TV 667

  Fly  1146 EESDQ 1150
            .|.|:
Worm   668 TEDDE 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDEase_I	870..1111	CDD:278654	166/240 (69%)
pde-4	NP_871945.1	PDEase_I	406..647	CDD:278654	166/240 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159310
Domainoid	1	1.000	356	1.000	Domainoid score	I513
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H129755
Inparanoid	1	1.050	602	1.000	Inparanoid score	I510
Isobase	1	0.950	-	0	Normalized mean entropy	S2320
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	1	1.000	-	-		oto18358
orthoMCL	1	0.900	-	-		OOG6_100782
Panther	1	1.100	-	-	LDO	PTHR11347
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4715
SonicParanoid	1	1.000	-	-		X171
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.880