Protein Alignment dnc and Pde5a

DIOPT Version :9

• Sequence 1: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Sequence 2: XP_006233322.1
• Gene: Pde5a / 171115
• RGDID: 620995
• Length: 865
• Species: Rattus norvegicus
• Alignment Length: 960
• Identity: 186/960 - (19%)
• Similarity: 339/960 - (35%)
• Gaps: 202/960 - (21%)

  Fly   241 VQQQQQQQQQLQQPLLQSQ-----PHFVPSSGNILSQVTLYSGSNPSTNP-CQSAVQNQGQNSNP 299
            ||.|||:.|...:..|...     .:||..:..  ..|..:........| |:..::...::.:.
  Rat     9 VQSQQQRDQDWVEAWLDDHRDFTFSYFVRKATR--DMVNAWFSERVHNIPVCKEGIRAHTESCSC 71

  Fly   300 NPNQNP---NTNPNQNQQRCSCQPQTSPLPHIKEEEESDQANFKHQTSLKEHQPLPPPITIATGY 361
            :..|:|   ||.|....::.|......||..|..::.....:|...:..||..||..| ...:..
  Rat    72 SLPQSPHADNTTPGAPARKISASEFDRPLRPIVVKDSEGTVSFLSDSGKKEQMPLTSP-RFDSDE 135

  Fly   362 CGSCESVHHSSATSSSAGTVPPGGQQTQEYIAGTSSTPSPRIKLKFRKPHKSCW--SRIVLAPIG 424
            ...|..:.......||...|.....:...:|.|..|.....:.|......|..:  ||:.....|
  Rat   136 GDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSKDKFLVSRLFDVAEG 200

  Fly   425 SAGGSSSATTVIGSNSNETLASSSTTGGTATTTQNSSSVSVAAHHRLTSSSASALATSHPSN-SQ 488
            |         .:...||..:......|             :..|         ..|...|.| ..
  Rat   201 S---------TLEEASNNCIRLEWNKG-------------IVGH---------VAAFGEPLNIKD 234

  Fly   489 LLPTSKMQAEQGSIGDLQKYHSRY-----LKNRRHTLANVRFDVENGQGARSPLEGGS------- 541
            .....:..||   :..:..|.::.     :||.|..:..|...:....|     .||:
  Rat   235 AYEDPRFNAE---VDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSG-----NGGTFTEKDEK 291

  Fly   542 ------PSAGLVLQNLPQRRESFLYRSDSDFEMSPKSMSRNS---SIASERFKEQEASILVDRSH 597
                  ...|:||.|      :.||      |.|.....||.   .:||..|:||::.
  Rat   292 DFAAYLAFCGIVLHN------AQLY------ETSLLENKRNQVLLDLASLIFEEQQSL------- 337

  Fly   598 GEDLIVTPFAQILASLRSVRNNLLSLTNVPASNKSRRPNQS--SSASRSGNPPGAPLSQGEEA-- 658
              ::|:...|..:.|...|:...:.:.:....:...|..|.  ....:|..    ||::..:|
  Rat   338 --EVILKKIAATIISFMQVQKCTIFIVDEDCPDSFSRVFQMEWEEVGKSSE----PLTREHDANK 396

  Fly   659 ----YTRLATDTIEELD-----------WCLDQLETIQTHRSVSDMASLKFK-----------RM 697
                |.:...:|:|.|:           |..:.:..|.|| .:..:.....|           ::
  Rat   397 INYMYAQYVKNTMEPLNIPDVTKDNRFPWTNENMGHISTH-CIGSLLCTPIKNGKKNKVIGVCQL 460

  Fly   698 LNK------ELSHFSESSRSGNQISEYICSTFLDKQQEFDLPSLRVEDNP---ELVAANAAAGQQ 753
            :||      ::..|:::.....:.....|...:...|.::.....:....   |:::.:|:|.::
  Rat   461 VNKMEEKTGKIKAFNQNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEE 525

  Fly   754 SAGQYARSRSPRGPPMSQISGVKRPLSHTNSFTGERLPTFGVETPRENELGTLLGELDTWGIQIF 818
            ...:           :..::....|.:.|...|.                              |
  Rat   526 ETRE-----------LQALAAAVVPSAQTLKITD------------------------------F 549

  Fly   819 SIGEFSVNRPLTCV-AYTIFQSRELLTSLMIPPKTFLNFMSTLEDHYVKDNPFHNSLHAADVTQS 882
            |..:|.::...|.: ...:|....|:.:..:..:....::.:::.:|.|:..:||..||.:..|.
  Rat   550 SFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQC 614

  Fly   883 TNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAV 947
            ....|....::...|.||....|.||..||:||.|:.|.::..|...||.:| ..|.:|:||...
  Rat   615 MFAALKAGKIQNKLTDLETLALLIAALSHDLDHRGVNNSYIQRSEHPLAQLY-CHSTMEHHHFDQ 678

  Fly   948 AFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMVETKKVAGSGVLLLD 1012
            ...:|.:.|..|...:..::.:|..|::...:|:||::.::....:...::...:.
  Rat   679 CLMVLNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNEF--------- 734

  Fly  1013 NYTDRIQ---VLENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKER-ESGMDISPMCDRHN 1073
            ::.|.:|   .|..|:...|||..|||.|:.:|...|:..|||.|||:|| |..|:.:.:.:|..
  Rat   735 SFEDPLQKELFLAMLMTACDLSAITKPWPIQQRIAELVAAEFFDQGDRERKELNMEPADLMNREK 799

  Fly  1074 AT-IEKSQVGFIDYIVHPLWETWADLVH--PDAQDILDTLEENRDYYQSM 1120
            .. |...||||||.|...|:|.   |.|  .|...:||...:||..:|::
  Rat   800 KNKIPSMQVGFIDAICLQLYEA---LTHVSEDCLPLLDGCRKNRQKWQAL 846

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDEase_I	870..1111	CDD:278654	73/247 (30%)
Pde5a	XP_006233322.1	GAF	154..311	CDD:214500	33/207 (16%)
		GAF	337..503	CDD:214500	24/179 (13%)
		PDEase_I	602..837	CDD:278654	73/247 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820