Protein Alignment dnc and Pde11a

DIOPT Version :9

• Sequence 1: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Sequence 2: NP_543169.1
• Gene: Pde11a / 140928
• RGDID: 621793
• Length: 935
• Species: Rattus norvegicus
• Alignment Length: 1189
• Identity: 229/1189 - (19%)
• Similarity: 396/1189 - (33%)
• Gaps: 383/1189 - (32%)

  Fly    37 NGQG-------LGGSCSANGLAATGGVGGGGGSGSGGGGCGSGSGSGSGKRKSKARTKCFGGTVF 94
            :|||       |.|:.|....:|.|..|.|||:|..|   .:.|...||
  Rat    44 SGQGASDLRPALAGASSLAQSSARGSTGIGGGAGPQG---SANSHPASG---------------- 89

  Fly    95 RCCLPCRGGGSAAPATSPPQTPAQTPDELKVIPEDCNLEKSAEQKRDLLERNNKEDDLLNRTVSG 159
                   ||.||....||........|.        ||::.|.||.            |.::.:.
  Rat    90 -------GGESAGVPLSPSWASGSRGDG--------NLQRRASQKE------------LRKSFAR 127

  Fly   160 SELDLYGGAGGGTKKHSLADTIDTSVTTPISLKTLINDVDEELDQQLSAADIAAASLASGLVARR 224
            |            |...:..|.|..||:             ...:.||:            |.||
  Rat   128 S------------KAIHVNRTYDEQVTS-------------RAQEPLSS------------VRRR 155

  Fly   225 AEPETLSDASVSPTAVVQQQQQQQQQLQQPLLQSQPHFVPSSGNILSQVTLYSGSNPSTNPCQSA 289
            |                             ||:......|::.:|||.:.
  Rat   156 A-----------------------------LLRKASSLPPTTAHILSALL--------------- 176

  Fly   290 VQNQGQNSNPNPNQNPNTNPNQNQQRCSCQPQTSPLPHIKEEEE--------SDQANFKHQTSLK 346
                  .|..|..|.|   |.....:|          |:|:..|        .|.:|....|||.
  Rat   177 ------ESRVNLPQYP---PTAIDYKC----------HLKKHNERQFFLELVKDISNDLDLTSLS 222

  Fly   347 EHQPLPPPITIATGYCGSCESVHHSSATSSSAGTVPPGGQQTQ-----EYIAGTSSTP------S 400
            ....:...:.:....| |...|..::|           |::|.     :..|||...|      |
  Rat   223 YKILIFVCLMVDADRC-SLFLVEGAAA-----------GKKTLVSKFFDVHAGTPLLPCSTTENS 275

  Fly   401 PRIKLKFRKPHKSCWSRIVLAPIGSAGGSSSATTVIG----SNSNETLASSSTTGGTATTTQNSS 461
            ..:::.        |.:.::..:|..|.:.:......    ::..:.|....|........:||.
  Rat   276 NEVQVP--------WGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLCMPIRNSD 332

  Fly   462 SVSVAAHHRLTSSSASALATSHP---------------SNSQLLPTSKMQAEQGSI--------- 502
            ...:.....:......|..|...               ||:||...|:.:.|:...
  Rat   333 GEIIGVAQAINKVPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLF 397

  Fly   503 ---GDLQKYHSRYLKNRRHTLANVRFDVENGQGARSPLEGGSPSAGLVLQNLPQRRESFLYRSDS 564
               .||:|...:.:...:..|...|..|                  |:|:::    ||.:.:...
  Rat   398 EEQTDLEKIVKKIMHRAQTLLKCERCSV------------------LLLEDI----ESPVVKFTK 440

  Fly   565 DFE-MSPKSMSRNSSIASERFKEQEASILVDRSHGED-LIVTPFAQILASLRSVRNNLLSLTNVP 627
            .|| ||||.    |:.|...|||.     |::|...| ||....|:::||           |.:|
  Rat   441 SFELMSPKC----SADAENSFKES-----VEKSSYSDWLINNSIAELVAS-----------TGLP 485

  Fly   628 --ASNKSRRPNQSSSASRSGNPPGAPLSQGEEAYTRLATDTIEELDWCLDQLETIQTHRSV---- 686
              .|:..:.|...:.|                                 ||:..... |||
  Rat   486 VNVSDAYQDPRFDAEA---------------------------------DQISGFHI-RSVLCVP 516

  Fly   687 ---SDMASLKFKRMLNK-ELSHFSESSRSGNQISEYICSTFLDKQQEFDLPSLRVEDNPELVAAN 747
               |:...:...::||: :...|.::.:...:.....|...::....:|
  Rat   517 IWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYD---------------- 565

  Fly   748 AAAGQQSAGQYARSRSPRGPPMSQIS-GVKRPLSHTNSFTGERLPTFGVETPRENELGTLLGELD 811
                     |..:|.:.:...:..:| ......:..:.|....:|              |:.||
  Rat   566 ---------QVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIP--------------LVSEL- 606

  Fly   812 TWGIQIFSIGEFSVN-RPLTCVAYTIFQSRELLTSLMIPPKTFLNFMSTLEDHYVKDNPFHNSLH 875
              .|......:||:: ..:...|..:|....::....|..:|...::.|:..:| :...:||..|
  Rat   607 --AIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNY-RMVLYHNWRH 668

  Fly   876 AADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQFLVNSSSELALMYNDESVL 940
            |.:|.|....:|.|...:.:.|.:|:...:.....||:||.|..|.|...|.|.||.:|...:.|
  Rat   669 AFNVCQLMFAMLTTAGFQEILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSDSALAQLYGTSATL 733

  Fly   941 ENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMVETKKVAG 1005
            |:||...|..:||::|.:||.|:..|:...|.:::...:|:||::.:.....:...:|.    .|
  Rat   734 EHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS----KG 794

  Fly  1006 SGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKERESGMDISP--M 1068
            :....:.::.|..:.:  |:...||...|||..:.::...|:..|||.|||:|| |.:.::|  :
  Rat   795 AYDWSITSHRDVFRSM--LMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRER-SELKLTPSAI 856

  Fly  1069 CDRHNA-TIEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEENRDYYQ------------SM 1120
            .||:.. .:.:.|:.:||.|..||::.... |:...:.:||::..||..::            |.
  Rat   857 FDRNRKDELPRLQLEWIDSICMPLYQALVK-VNAKLKPMLDSVAANRRKWEELHQKRLQVSAASP 920

  Fly  1121 IPPSPPPSGVDENPQEDRI 1139
            :|.||.|:...    |||:
  Rat   921 VPSSPSPAVAG----EDRL 935

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDEase_I	870..1111	CDD:278654	69/243 (28%)
Pde11a	NP_543169.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	41..125		30/126 (24%)
		GAF	217..380	CDD:214500	27/182 (15%)
		GAF	402..568	CDD:214500	46/266 (17%)
		PDEase_I	663..898	CDD:278654	69/242 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	915..935		7/23 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820