Protein Alignment dnc and LOC1273035

DIOPT Version :10

• Sequence 1: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Sequence 2: XP_311976.5
• Gene: LOC1273035 / 1273035
• VectorBaseID: AGAMI1_012236
• Length: 1494
• Species: Anopheles gambiae
• Alignment Length: 917
• Identity: 209/917 - (22%)
• Similarity: 343/917 - (37%)
• Gaps: 208/917 - (22%)

  Fly   374 TSSSAGTVPPGG------QQTQEYIAGTSS------------------TPSPRIKLKFRKPHKSC 414
            |.:...|||||.      |:.||.:|..:.                  || |.:.:      :.|
Mosquito    59 TLARTPTVPPGSPDQQYQQEGQEELANCTEEQEDTGLQLPVVIIADEVTP-PSVIV------EEC 116

  Fly   415 WSRIVLAPIGSAGGSSSATTVIGSNSNETLASSSTTGGTATTTQNSSSVSVAAHHRL-------- 471
            .....::|....|...|..:   ||...::........:.........:.:|.:|..
Mosquito   117 AEASEVSPTADRGDDESGES---SNQRNSVEDVGNVEESVRKLDQLEELVIAFYHSCGRRSSRGG 178

  Fly   472 --TSSSASALATSHPSNSQLLPTSKMQAEQGSIGDLQKYHSRYLKNRRHTLANVRFDVENGQGAR 534
              |..:||.......|.::...|.|.|.:.........||......:||.      |.:     |
Mosquito   179 ADTEQTASEAVRDGASRARAKRTKKRQQQSSGEACTGAYHPDQQHQKRHP------DPD-----R 232

  Fly   535 SPLEGGSPSAGLVLQNLPQRRESFLY------RSDSDFEMSPKSMSRNSS----IASERFKEQEA 589
            :..:|..|.         |.|:...:      .:.||..:.|....|..:    :.|......|.
Mosquito   233 TMNQGTDPD---------QDRDHLAHAAAAATSAPSDTSVVPAGDGRQQAQPQPLRSIHADAPEP 288

  Fly   590 SILVDRS---HGEDLIVTPFAQILASLRSVRNNLLSLTNVPASNKSRRPNQSSSASRSGNPPGAP 651
            ...:||.   ..|:..||..|:..:...| :..::::.......:::........|..|:.|...
Mosquito   289 GHSLDRDVPLDDEEDTVTLTAETSSECCS-QQTVVAVVAEEEEVEAQAEEVVEDGSSPGHDPTET 352

  Fly   652 LSQGEEAYT-------------RLATDTIEELDWC-----LDQLETIQTHR-SVSDMASLKFKRM 697
            ::.|.:..|             ..|.|..|..|.|     |.|..|..:.| |:......:..|.
Mosquito   353 VAPGSDTTTDDEVENDDTGGSDADANDEAEPGDTCTRRTVLGQDSTPSSRRCSLGGEFETEQNRR 417

  Fly   698 LNKELSHFSESSRSGNQISEYICSTFLDKQQEFDLPSLRVEDNPELVAANAAAGQQSAGQYARSR 762
            |.:.||..:.:..:..|..: :|.. ||...:.||..|..|...::..|      :.......|.
Mosquito   418 LRRRLSELTNNFCTPKQFQQ-LCDN-LDNITDNDLKLLVRELKRKIEFA------ERMNWLCLSS 474

  Fly   763 SPRGPPMSQIS-----GVKRPLSHT--NSFTGE-----RLPTFGVETPRENELGTLLGELDTWGI 815
            .|||||..:.|     .||:....|  .:.:.|     |||.|...            |.:.|.:
Mosquito   475 RPRGPPHRKTSLPKHTDVKKRFLETCDKTLSDEVKAALRLPAFDSY------------EWEDWDV 527

  Fly   816 QIFSIGEFSVNRPLTCVAYTIFQSRELLTSLMIPPKTFLNFMSTLEDHYVKDNPFHNSLHAADVT 880
                          ..:..|:|....||....||..|...::..:..|| .|.||||..|...|.
Mosquito   528 --------------IHLMQTMFVELNLLEKFNIPIVTLREWLYEVYKHY-NDVPFHNYRHCFCVA 577

  Fly   881 Q-------STNVLLNTPALEGVFTPLEVGGALFAACI-HDVDHPGLTNQFLVNSSSELALMYNDE 937
            |       .||::.....||.:        .|..:|| ||:||||..|.:.:|:.:||||.|||.
Mosquito   578 QMMYTIAWHTNLVQRLGELEVL--------VLLVSCICHDLDHPGYNNIYQINARTELALRYNDI 634

  Fly   938 SVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMVE--- 999
            |.|||||.::||:||::..|:||.||.|:..:.:|:.:|..:|:|||::|..:|...:....
Mosquito   635 SPLENHHCSIAFRLLEHPECNIFRNMSKEMYKDVREGIIRCILATDMARHNEILTQFQEATPEFD 699

  Fly  1000 -TKKVAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKERESGM 1063
             :.||          :|:.:.::  |:..||:||..:|:.:.:.||..|::|||.|...|:..|:
Mosquito   700 YSNKV----------HTNLLCMV--LIKVADISNEARPMDVAEPWVDRLLQEFFAQSAAEKSEGL 752

  Fly  1064 DISPMCDRHNATIEKSQVGFIDYIVHPLWETWADLVHPDAQDILDT-LEENRDYY---------- 1117
            .::|..|....:...|||.||..::.||:|...:|: |:..|::.| :....|||
Mosquito   753 PVTPFMDPDKVSKPGSQVRFIGLVLLPLFEALGELL-PELTDLIITPVRVALDYYRRLNDAANKT 816

  Fly  1118 -QSMIPPSPPPSGVDENPQEDRIRFQVTLEES--------------DQ-----ENLAELEEGDES 1162
             :|:.......|....:||..|.:..::::..              |:     ..|.:|.||.||
Mosquito   817 RRSIAEAEAASSESGGSPQLPRSQSGISVKSRRSIPSQKSASRTSVDEPILIAAELHDLPEGSES 881

  Fly  1163 GGESTTT 1169
            |...|.|
Mosquito   882 GDSETAT 888

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDE4_UCR	603..725	CDD:465648	25/140 (18%)
		PDEase_I	870..1110	CDD:459723	84/252 (33%)
LOC1273035	XP_311976.5	PDEase_I	567..795	CDD:459723	83/248 (33%)