DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dnc and Pde4c

DIOPT Version :9

Sequence 1:	NP_726846.1	Gene:	dnc / 31309	FlyBaseID:	FBgn0000479	Length:	1209	Species:	Drosophila melanogaster
Sequence 2:	XP_011240550.1	Gene:	Pde4c / 110385	MGIID:	99556	Length:	745	Species:	Mus musculus

Alignment Length:	818	Identity:	407/818 - (49%)
Similarity:	512/818 - (62%)	Gaps:	131/818 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   375 SSSAGTVPPGGQQTQEYIAGTSSTPSPRIKLKFRKPHKSCWSRIVLAPIGSAGGSSSATTVIGSN 439
            |..|...|.||.......:||                      ::|.|:.|..|||...
Mouse    22 SGVAPVSPLGGGVILRRFSGT----------------------LLLPPLSSRLGSSGEA------ 58

  Fly   440 SNETLASSSTTGGTATTTQNSSSVSVAAHHRLTSSSASALATSHPSN--SQLLPTSKMQAEQGSI 502
              |:.|....|.||..|.:|..|...::..  .|.||.|.....|.:  .||....::|
Mouse    59 --ESAAHVVFTIGTQGTQRNLGSAQSSSWR--PSLSARAGVPRSPKHLWGQLQRPIRIQ------ 113

  Fly   503 GDLQKYHS--------RYLKNRRHTLANV--RFDVENG-QGARSPLEGGS-PSAGLVLQ---NLP 552
               :::||        ..:|:|....::.  |||:||| .|.:..|:..| ||.|..||   :..
Mouse   114 ---RRFHSDPERPDRPAPVKSRLSWPSSFHRRFDLENGLPGGKGLLDAQSGPSLGRALQPPVHHV 175

  Fly   553 QRRESFLYRSDSDFEMSPKSMSRNSSIASERFKEQEASILVDRSHGEDLIVTPFAQILASLRSVR 617
            |||||||||||||.|.|||::||.||.||:             .||||:|||||||:|||||:||
Mouse   176 QRRESFLYRSDSDHEPSPKAVSRTSSAASD-------------LHGEDMIVTPFAQVLASLRTVR 227

  Fly   618 NNLLSLTNVPASNKSRRPNQSSSASRS---GNPP-----GAPLSQGEEAYTRLATDTIEELDWCL 674
            ||:.:|.:.|           .||:|.   |.||     .||.   |::..:|..:|:|||||||
Mouse   228 NNVAALAHGP-----------GSATRQVLLGTPPHSSQQAAPT---EDSGLQLVQETLEELDWCL 278

  Fly   675 DQLETIQTHRSVSDMASLKFKRMLNKELSHFSESSRSGNQISEYICSTFLDKQQEFDLPSLRVED 739
            :||||:||.|||.:|||.|||||||:|||:.||:||||||:||||..||||:|.|.:||....||
Mouse   279 EQLETLQTRRSVGEMASNKFKRMLNRELSYLSETSRSGNQVSEYISQTFLDQQAEVELPQPPTED 343

  Fly   740 NPELVAANAAAGQQSAGQYARSRSPRGPPMSQISGVKRPLSHTNSFTGERLPTFGVETPRENELG 804
            :|.                         ||:||:.::|. ||| |.....:|.|||:|.:|.:|.
Mouse   344 DPW-------------------------PMAQITELRRS-SHT-SLPTAAIPRFGVQTDQEEQLA 381

  Fly   805 TLLGELDTWGIQIFSIGEFSVNRPLTCVAYTIFQSRELLTSLMIPPKTFLNFMSTLEDHYVKDNP 869
            ..|.:.:.||:.:|.:.|.|.|||||.|.:::||.|:||.:..||..|.|.::.|||.||..|..
Mouse   382 KELEDTNKWGLDVFKVAELSGNRPLTAVIFSVFQERDLLKTFQIPADTLLAYLLTLEGHYHSDVA 446

  Fly   870 FHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQFLVNSSSELALMY 934
            :|||:|||||.||.:|||.|||||.|||.|||..|:||..||||||||::||||:|::|||||||
Mouse   447 YHNSMHAADVVQSAHVLLGTPALEAVFTDLEVLAAIFACAIHDVDHPGVSNQFLINTNSELALMY 511

  Fly   935 NDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMVE 999
            ||.||||||||||.|||||.:.||||.|:..|||.:||:||||:||:||||||||||||||||||
Mouse   512 NDSSVLENHHLAVGFKLLQGENCDIFRNLSTKQRLSLRRMVIDMVLATDMSKHMSLLADLKTMVE 576

  Fly  1000 TKKVAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKERESGMD 1064
            ||||...||||||||:||||||::||||||||||.||||||::|...:|.|||.|||:|||||:|
Mouse   577 TKKVTSLGVLLLDNYSDRIQVLQSLVHCADLSNPAKPLPLYRQWTERIMAEFFQQGDRERESGLD 641

  Fly  1065 ISPMCDRHNATIEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEENRDYYQSMIPPSPPPSG 1129
            ||||||:|.|::|||||||||||..|||||||||||||||::|||||:||::|||.||.|||
Mouse   642 ISPMCDKHTASMEKSQVGFIDYIAQPLWETWADLVHPDAQELLDTLEDNREWYQSRIPCSPP--- 703

  Fly  1130 VDENPQEDRIRFQVTLEESDQENLAELEEGDESGGEST 1167
              .....||.:|::||||:::|.    ||.||  |:.|
Mouse   704 --HTMGSDRFKFELTLEEAEEEE----EEEDE--GQCT 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDEase_I	870..1111	CDD:278654	183/240 (76%)
Pde4c	XP_011240550.1	PDE4_UCR	213..329	CDD:375549	71/129 (55%)
Pde4c	XP_011240550.1	PDEase_I	447..688	CDD:365964	183/240 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	409	1.000	Domainoid score	I695
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	744	1.000	Inparanoid score	I587
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	1	1.000	-	-		otm42764
orthoMCL	1	0.900	-	-		OOG6_100782
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X171
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.730