Protein Alignment dnc and PDE10A

DIOPT Version :9

• Sequence 1: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Sequence 2: NP_001372008.1
• Gene: PDE10A / 10846
• HGNCID: 8772
• Length: 1055
• Species: Homo sapiens
• Alignment Length: 1137
• Identity: 234/1137 - (20%)
• Similarity: 388/1137 - (34%)
• Gaps: 315/1137 - (27%)

  Fly    49 GLAATGGVGGGGGSGSGGGGCG---------------SGSGSGSGKRKSKARTKCFGGTVFRCCL 98
            |.||....||||.:|.|||| |               .|.|||.|:|:........|     ..|
Human   147 GAAAAAAAGGGGDAGGGGGG-GQEAAPLSVPTSSSHRGGGGSGGGRRRLFLSPALQG-----LLL 205

  Fly    99 PCRGG-----------GSAAPATSPPQTP-------AQTPDELKVIPEDCNLEKSAEQKRDLLER 145
            |.|.|           |.||.....|..|       .|||..    |:..:...:|...  ||..
Human   206 PARAGPRPPPPPRLPLGQAARRAGSPGFPGAGPGGGGQTPRR----PQGASFALAAAAA--LLFG 264

  Fly   146 NNKEDDLLNRTVSGSELDLYGGAGGGTKKHSLADTIDTSVTTPISLKTLINDVDEELDQQLSAAD 210
            ::.||               |.:...:....|.:...:...|...:|..::...:.||:.:|.:
Human   265 SDMED---------------GPSNNASCFRRLTECFLSPSLTDEKVKAYLSLHPQVLDEFVSES- 313

  Fly   211 IAAASLASGLVARRAEPETLSDASVSPTAVVQQQQQQQQQLQQPLLQSQPHFVPSSGNILSQVTL 275
            ::|.::...|..:..:.|..|    :|..|.:.|....|.:...|.......:.:.|:  :|:.|
Human   314 VSAETVEKWLKRKNNKSEDES----APKEVSRYQDTNMQGVVYELNSYIEQRLDTGGD--NQLLL 372

  Fly   276 YSGSN---PSTNPCQSAVQNQGQNSNPNPNQNPNTNPNQNQQRCSCQPQTSPLPHIKEEEESDQA 337
            |..|:   .:|.....|:...|:.:|               ..|...|     |.|||.:.
Human   373 YELSSIIKIATKADGFALYFLGECNN---------------SLCIFTP-----PGIKEGKP---- 413

  Fly   338 NFKHQTSLKEHQPLPP-PITIATGYCGSCESVHHSSATSSSAGTVPPGGQQTQEYIAGTSSTPSP 401
                       :.:|. |||..|...........:.......|        .:.:..||......
Human   414 -----------RLIPAGPITQGTTVSAYVAKSRKTLLVEDILG--------DERFPRGTGLESGT 459

  Fly   402 RIKLKFRKPHKSCWSRIVLAPIGSAGGSSSATTVIG------SNSNETLASSSTTGGTATTTQNS 460
            ||:            .::..||.:|.|.     :||      ....|....|.....||    |.
Human   460 RIQ------------SVLCLPIVTAIGD-----LIGILELYRHWGKEAFCLSHQEVATA----NL 503

  Fly   461 SSVSVAAHHRLTSSSASALATSHPSNSQLLPTSKMQAEQ-GSIGDLQKYHSRYLKNRRHTLANVR 524
            :..|||.|.   ......||.....|..||..||...:. .:|..|.::...|.||..:......
Human   504 AWASVAIHQ---VQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCAL 565

  Fly   525 FDVENGQGARSPLEGGSPSAGLVLQNLPQRRESFLYRSDSDFEMSPKSMSRNSSIASERFKEQEA 589
            |.|::                                             :|..:.|:.|
Human   566 FQVDH---------------------------------------------KNKELYSDLF----- 580

  Fly   590 SILVDRSHGEDLIVTPFAQILASLR-SVRNNLLSLTNVPASNKSRRPNQSSSASRSGNPPGAPLS 653
                  ..||:....|..:....:| |:...:                 :...:|:|.....|.:
Human   581 ------DIGEEKEGKPVFKKTKEIRFSIEKGI-----------------AGQVARTGEVLNIPDA 622

  Fly   654 QGEEAYTRLATDTIEELDWCLDQLETIQTHRS------VSDMASLKFKRMLNK-ELSHFSESSRS 711
            ..:..:.|       |:|     |.|..|.|:      ||..:.:...:|:|| ..|.||::.
Human   623 YADPRFNR-------EVD-----LYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTD-- 673

  Fly   712 GNQISEYICSTFLDKQQEFDLPSLRVEDNPELVAANAAAGQQSAGQYARSRSPRGPPMSQISGVK 776
                                      |:|.::.|...|.....|..|.|.|  ....:.:::..|
Human   674 --------------------------ENNFKMFAVFCALALHCANMYHRIR--HSECIYRVTMEK 710

  Fly   777 RPLSHTNSFTGERLP-----TFGVETPRENELGTLLGELDTWGIQIFSIGEFSVNRPLTCVAYTI 836
              ||:.:..|.|...     |..|...:|.||..            |.||.|....|...| |.:
Human   711 --LSYHSICTSEEWQGLMQFTLPVRLCKEIELFH------------FDIGPFENMWPGIFV-YMV 760

  Fly   837 FQS-----RELLTSLMIPPKTFLNFMSTLEDHYVKDNPFHNSLHAADVTQSTNVLL-NTPALEGV 895
            .:|     .||        :....|:.:::.:| :..|:||..||..|......:| |...|
Human   761 HRSCGTSCFEL--------EKLCRFIMSVKKNY-RRVPYHNWKHAVTVAHCMYAILQNNHTL--- 813

  Fly   896 FTPLEVGGALFAACIHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNQGCDIF 960
            ||.||..|.|.|...||:||.|.:|.:|......||.:|: .|.:|.||.:....:||.:|.:||
Human   814 FTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYS-TSTMEQHHFSQTVSILQLEGHNIF 877

  Fly   961 CNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLENLV 1025
            ..:...:.:.:.:::...:::||::.:......|:.|.:|      |.|.|:|.:.|.:|:..::
Human   878 STLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQT------GSLNLNNQSHRDRVIGLMM 936

  Fly  1026 HCADLSNPTKPLPLYKRWVALLMEEFFLQGDKERESGMDISPMCDRHNA-TIEKSQVGFIDYIVH 1089
            ...||.:.||..|:.|.....:..||:.:||:.::.|:...||.||... .:.:.|:||.:.:..
Human   937 TACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAI 1001

  Fly  1090 PLWETWADLVHPDAQDILDTLEENRDYYQSMI 1121
            |.:.|...:: |..:.:|....:|...::.:|
Human  1002 PCYTTLTQIL-PPTEPLLKACRDNLSQWEKVI 1032

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDEase_I	870..1111	CDD:278654	67/242 (28%)
PDE10A	NP_001372008.1	GAF	367..510	CDD:396252	37/208 (18%)
		GAF	543..698	CDD:214500	40/267 (15%)
		PDEase_I	790..1022	CDD:395177	67/242 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820