Protein Alignment dnc and pde7a

DIOPT Version :10

• Sequence 1: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Sequence 2: XP_031760262.1
• Gene: pde7a / 100498541
• XenbaseID: XB-GENE-1013813
• Length: 480
• Species: Xenopus tropicalis
• Alignment Length: 504
• Identity: 146/504 - (28%)
• Similarity: 240/504 - (47%)
• Gaps: 57/504 - (11%)

  Fly   626 VPASNKSRRP--NQSSSASRSGNPPGAPLSQGEEAYTRLATDTIEELDWCLDQLETIQTHRSVSD 688
            ||....|||.  :.|||::..|.|....|||  :...|....:.:..|         ||...:..
 Frog    16 VPKHVLSRRGAISFSSSSALFGCPNPRQLSQ--DHVKRRGAISYDSSD---------QTALYIRM 69

  Fly   689 MAS-LKFKRMLNKELSHFS----ESSRSGNQISEYICSTFLDKQQEFDLPSLRVEDNPELVAANA 748
            :.| :.||::..:::...|    ||.|.|:.  .||....|....|.:: ||...:...|:
 Frog    70 LGSCVIFKQLSARDVRVRSRAGFESERRGSH--PYIDFRILHSHSEIEI-SLSARNIRRLL---- 127

  Fly   749 AAGQQSAGQYARSRSPRGPPMSQISGVKRPLSHTNSFTGERLPTFGVETPRENELGTLLGELDTW 813
                 |..:|.:|           |...|.::..||.       :.::.....:...:|.::.:|
 Frog   128 -----SFQRYLKS-----------SRFFRGVTAQNSL-------YILDDDYNGQAKCMLEKVGSW 169

  Fly   814 GIQIFSIGEFSVNRPLTCVAYTIFQSRELLTSLMIPPKTFLNFMSTLEDHYVKDNPFHNSLHAAD 878
            ...||.....:....|..:.:.:.....|:....:.......|:..:::.|...||:||::||||
 Frog   170 SFDIFLFDRLTNGNSLVTLTFHLLSHHGLIDHFQLDMVKLRRFLVMVQEDYHSQNPYHNAVHAAD 234

  Fly   879 VTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQFLVNSSSELALMYNDESVLENH 943
            |||:....|..|.|...|||.::...|.||..||:||||:...||:.::..||.:|.:.||||||
 Frog   235 VTQAMYCFLKEPKLAKSFTPWDILLGLIAAATHDLDHPGVNQSFLIKTNHYLATLYKNTSVLENH 299

  Fly   944 HLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMVETKKVAGSGV 1008
            |...|..||:..|  :|.:|..::||.:...:..|:|:||:|:....|:..:|.::      .|.
 Frog   300 HWRSAVGLLRESG--LFAHMTLEERQHMEGQLGSIILATDISRQNEYLSQFRTHLD------RGD 356

  Fly  1009 LLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKERESGMDISPMCDRHN 1073
            |.|||.:||:.:|:..:.|||:.||.:...|.|:|...:.||||.|||.||:..:|:||:|||..
 Frog   357 LCLDNASDRLFILQMALKCADICNPCRTWELSKQWSEKVTEEFFYQGDVERKYKLDVSPLCDRQT 421

  Fly  1074 ATIEKSQVGFIDYIVHPLWETWADLVHPD-AQDILDTLEENRDYYQSMI 1121
            :.|...|:|||.|:|.||:..||...:.. :|.:|..:..|:..::.|:
 Frog   422 SNIANIQIGFITYLVEPLFVEWARFSNTRLSQTMLGHVGLNKASWKGML 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDE4_UCR	603..725	CDD:465648	27/105 (26%)
		PDEase_I	870..1110	CDD:459723	95/240 (40%)
pde7a	XP_031760262.1	PDEase_I	226..446	CDD:459723	93/227 (41%)