Protein Alignment dnc and pde4d

DIOPT Version :10

• Sequence 1: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Sequence 2: XP_031749923.1
• Gene: pde4d / 100496479
• XenbaseID: XB-GENE-1013100
• Length: 912
• Species: Xenopus tropicalis
• Alignment Length: 1001
• Identity: 460/1001 - (45%)
• Similarity: 579/1001 - (57%)
• Gaps: 235/1001 - (23%)

  Fly   244 QQQQQQQLQQPLLQSQPHFV-------------PSSGNILSQVTLYSGSNP-------------- 281
            :|:|||:.|.|.|.....||             |.:..:|||..:|...:|
 Frog    40 RQEQQQRWQCPALHHHQSFVQHQEPPAPLHPALPDTPLLLSQQNIYPLLHPLPLAQINPALQPQI 104

  Fly   282 -STNPCQSAVQ------------NQGQNSNPNPNQ-NPNTNPN---------QNQQRCSCQPQTS 323
             |..|.|.|.|            :|.|:...:|:| :|...|.         .:|...:.|||:.
 Frog   105 YSVLPSQPAPQILPALQAHIYPVHQPQSPALSPSQVSPGLQPQIYPDLQPQPSSQINPALQPQSP 169

  Fly   324 P----LPHIKEEEESDQANFKHQTSL-KEHQPLP--PPITIATGYCGSCESVHHSSATSSSAGTV 381
            |    .||       ....|:.|..| .:.||.|  ||::..|.|..|  .|.|.
 Frog   170 PQIQAQPH-------PLLPFQLQPQLHSQAQPAPHCPPVSSRTRYSNS--RVRHR---------- 215

  Fly   382 PPGGQQTQEYIAGTSSTPSPRIKLKFRKPHKSCWSRIVLAPIGSAGGSSSATTVIGSNSNETLAS 446
              |...|:.|:
 Frog   216 --GFSDTERYL------------------------------------------------------ 224

  Fly   447 SSTTGGTATTTQNSSSVSVAAHHRLTSSSASALATSHPSNSQLLPTSKMQAEQGSIGDLQKYHSR 511
                                 |.:....|:.|:.|.|...   |..|:|           .:.|.
 Frog   225 ---------------------HCQAMDRSSYAVDTGHRPG---LKKSRM-----------SWPSS 254

  Fly   512 YLKNRRHTLANVRFDVENG-QGARSPLEG-GSPSAGLVLQ-NL--PQRRESFLYRSDSDFEMSPK 571
            :...|       ||||:|| ...||||:. .||.:||:|| |.  .|||||||||||||:|:|||
 Frog   255 FQGFR-------RFDVDNGTTSGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYELSPK 312

  Fly   572 SMSRNSSIASERFKEQEASILVDRSHGEDLIVTPFAQILASLRSVRNNLLSLTNVPASNKSRRPN 636
            ||||||||||:             .||:|||||||||:|||||:||||..:|||:    :.|.|:
 Frog   313 SMSRNSSIASD-------------IHGDDLIVTPFAQVLASLRTVRNNFAALTNL----QDRAPS 360

  Fly   637 QSSSASR--SGNPPGAPLSQGEEAYTRLATDTIEELDWCLDQLETIQTHRSVSDMASLKFKRMLN 699
            :.|:...  |.|....|    ||||.:||.:|:||||||||||||:||..|||:|||.|||||||
 Frog   361 KRSTMCNQPSINKATIP----EEAYQKLAGETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLN 421

  Fly   700 KELSHFSESSRSGNQISEYICSTFLDKQQEFDLPSLRVEDNPELVAANAAAGQQSAGQYARSRSP 764
            :||:|.||.||||||:||||.:||||||.|.::|                    |..|..:.:..
 Frog   422 RELTHLSEMSRSGNQVSEYISNTFLDKQHEVEMP--------------------SPAQKEKEKKK 466

  Fly   765 RGPPMSQISGVKRPLSHTNSFTGERLPTFGVETPRENELGTLLGELDTWGIQIFSIGEFSVNRPL 829
            |  |||||||||: |.|::|.|...:|.|||::..|..|...|.:::.||:.||.:.|||.||||
 Frog   467 R--PMSQISGVKK-LMHSSSLTNSNIPRFGVKSENEECLAKELEDVNKWGLNIFKVAEFSGNRPL 528

  Fly   830 TCVAYTIFQSRELLTSLMIPPKTFLNFMSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEG 894
            |.|.:||||.||:|.:..||..|.:.::.||||||..|..:||::|||||.|||:|||::||||.
 Frog   529 TVVMHTIFQEREMLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVAQSTHVLLSSPALEA 593

  Fly   895 VFTPLEVGGALFAACIHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNQGCDI 959
            |||.||:..|:||:.||||||||::||||:|::|||||||||.||||||||||.|||||.:.|||
 Frog   594 VFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDI 658

  Fly   960 FCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLENL 1024
            |.|:.|||||.||||||||||:|||||||:||||||||||||||..|||||||||:||||||:|:
 Frog   659 FQNLTKKQRQLLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNM 723

  Fly  1025 VHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKERESGMDISPMCDRHNATIEKSQVGFIDYIVH 1089
            ||||||||||||||||:.|...:|||||.|||:|||.||:||||||:|||::|||||||||||||
 Frog   724 VHCADLSNPTKPLPLYRHWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVH 788

  Fly  1090 PLWETWADLVHPDAQDILDTLEENRDYYQSMIP--PSPPPSGVDENP--QEDRIRFQVTLEE--- 1147
            ||||||||||||||||||||||:||::|||.||  |||.|...:|..  |.::.:|::||||
 Frog   789 PLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDEQEEGKQGQTEKFQFELTLEEDGE 853

  Fly  1148 --SDQENLAELEEGDESGGESTTTGT 1171
              :::::.:::|| |.|..:|.|..|
 Frog   854 SDTEKDSGSQVEE-DTSCSDSKTLCT 878

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDE4_UCR	603..725	CDD:465648	75/123 (61%)
		PDEase_I	870..1110	CDD:459723	190/239 (79%)
pde4d	XP_031749923.1	Atrophin-1	<76..>199	CDD:460830	29/129 (22%)
		PDE4_UCR	331..447	CDD:465648	75/123 (61%)
		PDEase_I	569..809	CDD:459723	190/239 (79%)