Protein Alignment dnc and pde1c

DIOPT Version :10

• Sequence 1: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Sequence 2: XP_031759760.1
• Gene: pde1c / 100495383
• XenbaseID: XB-GENE-994226
• Length: 762
• Species: Xenopus tropicalis
• Alignment Length: 569
• Identity: 159/569 - (27%)
• Similarity: 269/569 - (47%)
• Gaps: 93/569 - (16%)

  Fly   578 SIASERFKE-QEASILVD-------RSHGEDLIVTPFAQIL--ASLRSVRNNLLSLTNVPASNK- 631
            |...|.||: :.|:..:|       .:...|....|.|:..  .|..|:.|.::|..|:....|
 Frog     5 SSRKEGFKKCRSATFSIDGFSFTIVANEAGDKNARPLARFARSKSQNSLWNTIISGLNLKEKQKP 69

  Fly   632 -----SRRPNQ--SSSASRSGNPPGAP------------LSQGEEAYTRLATDTIEELDWCLDQL 677
                 .|.|.:  :....:..:|...|            |.:||.:    ..|..:.|::....|
 Frog    70 AIATDPRSPEEILADELPQVDSPDAIPKASIRLRCLVKQLERGEAS----VVDLKKNLEYAATVL 130

  Fly   678 ETIQTHRSVSDMASLKFKRMLN--KELSHFSESSRSGNQISEYICSTFLDKQQEFDLPSLRVEDN 740
            |::....:         :|:|:  .|||.. :|....:::.:::.|||   .::..:...|.|:.
 Frog   131 ESVYIDET---------RRLLDTEDELSDI-QSDSVPSEVRDWLASTF---TRQMGMMLKRTEEK 182

  Fly   741 PELVAANAAAGQQSAGQYARSRSPRGPPMSQISGVKRPLSHTNSFTGERLPTFGVETPRENELGT 805
            |...:...|.   .||.:                |:|....|::..|...|...:         .
 Frog   183 PRFRSIVHAV---QAGIF----------------VERMYRRTSNMVGLSYPPAVI---------A 219

  Fly   806 LLGELDTWGIQIFSIGEFSVNRPLTCVAYTIFQSRELLTSLMIPPKTFLNFMSTLEDHYVK-DNP 869
            :|..:|.|...:|::.:.|.:..|..:.|.:....:|:....||....::|:..||..|.| .||
 Frog   220 VLKNVDKWSFDVFALNDASGDHGLKFIFYELLTRYDLINRFKIPISALVSFVEALEVGYTKHKNP 284

  Fly   870 FHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQFLVNSSSELALMY 934
            :||.:|||||||:.:..|....|....|.||:...:|||.:||.:|.|.||.|.:.:.|:.|::|
 Frog   285 YHNLIHAADVTQTVHYFLFKSGLVHWLTELEIFAMIFAAAVHDYEHTGTTNNFHIQTRSDSAILY 349

  Fly   935 NDESVLENHHLAVAFKLLQ-NQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMV 998
            ||.|||||||::.|::||| ::..:|..|:.|...:..|.:||::||:||||.|...:..:|..:
 Frog   350 NDRSVLENHHVSAAYRLLQDDEEMNILYNLSKDDWREFRALVIEMVLATDMSCHFHQIKQMKNAL 414

  Fly   999 ETKKVAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKERESGM 1063
            :..:    |:       |:.:.|..|:|.||:|:|.|...|:.||...|:||||.|||||.|.|:
 Frog   415 QQPE----GI-------DKPKALSLLLHTADISHPAKNWDLHHRWTMSLLEEFFRQGDKEAELGL 468

  Fly  1064 DISPMCDRHNATIEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEE 1112
            ..||:|||::..:.:||:||||:||.|.:....|::.   :.::..:||
 Frog   469 PFSPLCDRNSTMVAQSQIGFIDFIVEPTFTVLTDMIE---KIVVPLIEE 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDE4_UCR	603..725	CDD:465648	28/145 (19%)
		PDEase_I	870..1110	CDD:459723	94/240 (39%)
pde1c	XP_031759760.1	PDEase_I_N	140..200	CDD:462497	16/82 (20%)
		PDEase_I	285..507	CDD:459723	94/235 (40%)