DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dnc and pde6a

DIOPT Version :9

Sequence 1:	NP_726846.1	Gene:	dnc / 31309	FlyBaseID:	FBgn0000479	Length:	1209	Species:	Drosophila melanogaster
Sequence 2:	XP_002936750.3	Gene:	pde6a / 100489913	XenbaseID:	XB-GENE-988755	Length:	866	Species:	Xenopus tropicalis

Alignment Length:	559	Identity:	127/559 - (22%)
Similarity:	219/559 - (39%)	Gaps:	133/559 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   616 VRNNLLSLTNVPASNKSRRPNQSSSASRSGNPPGAPLSQGEEAYTR----------LATDTIEEL 670
            :..|:||:   |..||  :......|:......|.|..:.:|..|.          |.|||.|::
Frog   381 IMKNVLSM---PIVNK--KEEILGVATFYNRKDGKPFDEMDEVLTESLTQFLGWSVLNTDTYEKM 440

  Fly   671 DWCLDQLETIQTHRSVSDMASLKFKRMLNKELSHFSESSRSGNQISEYICSTFLDKQQEFDLPSL 735
            :...::.:..|      ||.:...| ..|.||....::....|::.|        :.:|.:|..:
Frog   441 NKLENRKDIYQ------DMVNYHVK-CSNDELQIILKTKEIYNRLPE--------ECEEEELYEI 490

  Fly   736 RVEDNPELVAANAAAGQQSAGQYARSRSPRGPPMSQISGVKRPLSHTNSFTGERLPTFGVETPRE 800
            ..|:.|:                                                       |.|
Frog   491 LQEELPD-------------------------------------------------------PTE 500

  Fly   801 NELGTLLGELDTWGIQIFSIGEFSVNRP-LTCVAYTIFQSRELLTSLMIPPKTFLNFMSTLEDHY 864
            .|            |..|...:..|:.. |...|..|:...|::....||.:..:.|:.::...|
Frog   501 AE------------IYEFHFSDLPVSELFLVKCAIQIYYELEVVDKFHIPQEVLVRFLFSVSKGY 553

  Fly   865 VKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQFLVNSSSE 929
            .|.. :||..|..:|.|:...||.|..|:..:|.||....:.||..||:||.|..|.:.:.|...
Frog   554 RKIT-YHNWRHGFNVGQTMFTLLMTGNLKRYYTDLEAMAMVTAAFCHDIDHRGTNNLYQMKSGHP 617

  Fly   930 LALMYNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADL 994
            ||.::. .|:||.|||.....||:::..:||.|:.::|......|:...:::||::.:....|..
Frog   618 LAKLHG-SSILERHHLEFGKFLLKDESLNIFQNLNRRQYDHAIHMMDIAIIATDLALYFKKRAMF 681

  Fly   995 KTMVE-----TKKVAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQ 1054
            :.:|:     |.:...:..::|:.....| |:..::...|||...||..:..:...|:..||:.|
Frog   682 QKIVDQSQTFTSEKDWTEYMMLEQTRKEI-VMAMMMTACDLSAIAKPWDIQSKVALLVAAEFWEQ 745

  Fly  1055 GDKERE-SGMDISPMCDRHNA-TIEKSQVGFIDYIVHPLWETWADLVHPDAQDILD--------- 1108
            ||.||. ...:..||.||:.| .:.|.|.||||::...:::.::.. ||:.|.:.|
Frog   746 GDLERTVLQQNPIPMMDRNKADELPKLQCGFIDFVCTFVYKEFSRF-HPEIQPMYDGILNNKKEW 809

  Fly  1109 ------------TLEENRDYYQSMIPPS--PPPSGVDEN 1133
                        ||||::...:.:.||.  |.|: |.||
Frog   810 KKLADEYDAKMKTLEEDKQKKEGIQPPKQVPQPT-VREN 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDEase_I	870..1111	CDD:278654	73/268 (27%)
pde6a	XP_002936750.3	GAF	73..232	CDD:214500
		GAF	254..441	CDD:214500	16/64 (25%)
		PDEase_I	558..802	CDD:395177	72/246 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920