Protein Alignment dnc and pde4a

DIOPT Version :9

• Sequence 1: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Sequence 2: XP_031755243.1
• Gene: pde4a / 100488846
• XenbaseID: XB-GENE-5789473
• Length: 744
• Species: Xenopus tropicalis
• Alignment Length: 706
• Identity: 415/706 - (58%)
• Similarity: 496/706 - (70%)
• Gaps: 68/706 - (9%)

  Fly   468 HHRLTSSSASALATS-HPSNSQLLPTSKMQAEQGSIGDLQKYHSRYLKNRRHTLANVRFDVENGQ 531
            |.......|.|:.|| .|.    |..|:|.......|.....|:.:.:         |||||||.
 Frog    53 HPHRQMERADAMDTSDRPG----LRKSRMSWPSSFHGTTSNSHASHKQ---------RFDVENGP 104

  Fly   532 G-ARSPLEGGSPSAGLVLQ-NLP--QRRESFLYRSDSDFEMSPKSMSRNSSIASERFKEQEASIL 592
            . .|||:: ...|.||||. :.|  |||||||||||||::||||:||||||:.||
 Frog   105 SPGRSPID-SQASPGLVLHPSFPQSQRRESFLYRSDSDYDMSPKTMSRNSSVTSE---------- 158

  Fly   593 VDRSHGEDLIVTPFAQILASLRSVRNNLLSLTNVPASNKSRRPNQSSSASRSGNPPGAPLSQGEE 657
               :|.||||||||||:||||||||||...|.||......|.|.........     |.||  ||
 Frog   159 ---AHAEDLIVTPFAQVLASLRSVRNNFTILANVTTPTNKRSPVMPQQTVCK-----ATLS--EE 213

  Fly   658 AYTRLATDTIEELDWCLDQLETIQTHRSVSDMASLKFKRMLNKELSHFSESSRSGNQISEYICST 722
            .|.:||.:|:||||||||||||:||:||||:|||.|||||||:||:|.||.||||||:||||.:|
 Frog   214 TYQQLAKETLEELDWCLDQLETMQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNT 278

  Fly   723 FLDKQQEFDLPSLRVEDNPELVAANAAAGQQSAGQYARSRSPRGPPMSQISGVKRPLSHTNSFTG 787
            |||||.|.|:|                    |..|..|.:..:..||.||||||: |.|::|.|.
 Frog   279 FLDKQNEVDIP--------------------SPTQKEREKKKKQQPMCQISGVKK-LMHSSSLTN 322

  Fly   788 ERLPTFGVETPRENELGTLLGELDTWGIQIFSIGEFSVNRPLTCVAYTIFQSRELLTSLMIPPKT 852
            ..:|.|||:|.:|..||..|..|:.||:.||.:.|:|.||||:|..||:||.||||.:..||..|
 Frog   323 SAIPRFGVKTDQEESLGKELDNLNKWGLNIFRVAEYSNNRPLSCTMYTVFQERELLKTFKIPVDT 387

  Fly   853 FLNFMSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPG 917
            .:.:|.||||||..|..:|||||||||||||:|||:||||:.|||.||:..|||||.||||||||
 Frog   388 LMTYMMTLEDHYHADVAYHNSLHAADVTQSTHVLLSTPALDAVFTDLEILAALFAAAIHDVDHPG 452

  Fly   918 LTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLST 982
            ::||||:|::||||||||||||||||||||.|||||.:.||||.|:.|:||||:||||||:||:|
 Frog   453 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEENCDIFQNLTKRQRQTMRKMVIDMVLAT 517

  Fly   983 DMSKHMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALL 1047
            |||||||||||||||||||||..||||||||||||||||.|:|||||||||||||.||::|...:
 Frog   518 DMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKPLELYRQWTDRI 582

  Fly  1048 MEEFFLQGDKERESGMDISPMCDRHNATIEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEE 1112
            :||||.|||||||.||:||||||:|.|::|||||||||||||||||||||||||||||||||||:
 Frog   583 LEEFFRQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLED 647

  Fly  1113 NRDYYQSMIP--PSPPPSGVDENPQE--DRIRFQVTLEE----SDQENLAELEEGD 1160
            |||:||.|||  |||||...|::.:.  ::.:|::||||    ||::..:.:||.|
 Frog   648 NRDWYQGMIPQSPSPPPDDPDKDEEACIEKFQFELTLEEEAEDSDKDRNSGIEEED 703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDEase_I	870..1111	CDD:278654	195/240 (81%)
pde4a	XP_031755243.1	PDE4_UCR	166..281	CDD:407935	75/121 (62%)
		PDEase_I	405..646	CDD:395177	195/240 (81%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	414	1.000	Domainoid score	I665
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	763	1.000	Inparanoid score	I546
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	1	1.000	-	-		otm47870
Panther	1	1.100	-	-	O	PTHR11347
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X171
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160