Protein Alignment dnc and pde3b

DIOPT Version :10

• Sequence 1: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Sequence 2: XP_031756238.1
• Gene: pde3b / 100487373
• XenbaseID: XB-GENE-486086
• Length: 1015
• Species: Xenopus tropicalis
• Alignment Length: 1187
• Identity: 268/1187 - (22%)
• Similarity: 393/1187 - (33%)
• Gaps: 457/1187 - (38%)

  Fly    97 CLPCRGGGSAAPATSPPQTPAQTPDELKVIPEDCNLEKSAEQKRDLLERNNKEDDLLNRTVSGSE 161
            ||...||...|.|:.|...|..:..|...:|.             :..|.......|..|.:
 Frog   155 CLAGLGGVLLALASRPAPPPRSSILEADKVPV-------------IRPRRRSSCVSLGETPN--- 203

  Fly   162 LDLYGGAGGGTKKHSLADTIDTSVTTP-ISLKTLIN---DVDEELDQQLSAA------DIAAASL 216
             ..|||:..| ::.||          | ||.:.:|.   |:.:....|..:|      |::..:.
 Frog   204 -SYYGGSKMG-RRPSL----------PCISREQMILWDWDLKQWYKPQYQSAGGGNGVDLSVLNE 256

  Fly   217 ASGLVARRAEPETLSDASVSPTAVVQQQQQQQQQLQQPLLQSQPHFVPSSGNILSQVTLYSGS-N 280
            |..:||     :.|:|.|:|                       |..:.|..:|.|.:..:||| .
 Frog   257 ARNMVA-----DILADPSLS-----------------------PQVISSLRSISSLMGTFSGSCR 293

  Fly   281 PSTNPCQSAVQNQGQNSNPNPNQNPNTNPNQNQQRCSCQPQTSPLPHIKEEEESDQANFKHQTSL 345
            |..||           ..|.|...|          |:           :.|:..|:...|....|
 Frog   294 PKINP-----------FTPFPGFYP----------CN-----------EVEDPMDKVERKPHKGL 326

  Fly   346 KEHQPLPPPITIATGYCGSCESVHHSSATSSSAGTVPP-----------GGQQTQEYIAGTSSTP 399
            .....||.|                ....||.|..:||           |.:..||||
 Frog   327 NSRNSLPTP----------------QLRRSSGASILPPMELPPRWERSNGKRPHQEYI------- 368

  Fly   400 SPRIKLKFRKPHKSCWSRIVLAPIGSAGGSSSATTVIGSNSNETLASSSTTGGTATTTQNSSSVS 464
                                        |:|.     ||..|...:|:..|    ...|.||||:
 Frog   369 ----------------------------GASQ-----GSYPNGPYSSNLLT----IPKQRSSSVT 396

  Fly   465 VAAHH---RLTSSSASALATSHPSNSQLLPTSKMQAEQGSIGDLQKYHSRYLKNRRHTLANVRFD 526
            : .||   |...:|.|....:.||
 Frog   397 L-THHIGPRRAGTSPSLSPVNSPS----------------------------------------- 419

  Fly   527 VENGQG-ARSPLEGGSPSAGLVLQNLPQRRESFLYRSDSDFEMSPKSMSRNSSIASERFKEQEAS 590
              :|.| :|:|:|            .|...: ||.:.......:|..:|     .|:.|:.|
 Frog   420 --HGSGFSRAPVE------------FPDTAD-FLTKPSVTLHKTPGLVS-----TSQDFQPQ--- 461

  Fly   591 ILVDRSHGEDLIVTPFAQILASLRSVRNNLLSLTNVPASNKS---------RRPNQSSSASRSGN 646
                       :..|.:.|..|..  |..|..|:|..|::.|         |.|.:|.:...|..
 Frog   462 -----------VRPPTSHICTSCG--RPILKHLSNTEATDTSSQSGTEHQARNPAESGTGGNSQK 513

  Fly   647 PPGAPLSQGEEAYTRLATDTIEELDWCLDQLETIQTHRSVSDMASLKFKRMLNKELSH--FSESS 709
            .||....:.:|  |||..||                 |:||:              :|  ::|..
 Frog   514 EPGHLKEKAQE--TRLHKDT-----------------RNVSE--------------THEPYTEPG 545

  Fly   710 RSGNQISEYICSTFLDKQQEFDLPSLRVEDNPELVAANAAAGQQSAGQYARSRSPRGPPMSQISG 774
            ::|.:         .:.::|..|..:.:||.
 Frog   546 QAGRE---------SEMKEESPLELMLIEDQ---------------------------------- 567

  Fly   775 VKRPLSHTNSFTGERLPTFGVETPRENELGTLLGELDTWGIQIFSIGEFS---VNRPLTCVAYTI 836
                                         .:||..||.|...||.:.|.:   ..|.|:.|:||:
 Frog   568 -----------------------------DSLLDRLDNWNFPIFDLVERTGGKSGRILSQVSYTL 603

  Fly   837 FQSRELLTSLMIPPKTFLNFMSTLEDHYVKDNPFHNSLHAADVTQS------------------- 882
            ||...|.....||.:.|.||...||..| :|.|:||.:||.||..|
 Frog   604 FQDTGLFEIFKIPLREFQNFFRALESGY-RDIPYHNRIHATDVLHSVWYLSTRPIPGFHEIHSDE 667

  Fly   883 -----------TNVLL-----------------NTPALEGVFTPLEVGGALF-AACIHDVDHPGL 918
                       :.|.|                 |.||||.:        ||| ||.:||.||||.
 Frog   668 TDPDPDAEGGASQVFLTSKTCKLPDESYGCLSSNIPALELM--------ALFVAAAMHDYDHPGR 724

  Fly   919 TNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNQGCDIFCN-MQKKQRQTLRKMVIDIVLST 982
            ||.|||.:::..|::|||.|||||||.|.|:.|..:|....|.. :...|.:..|.:||:.:|:|
 Frog   725 TNAFLVATNAPQAVLYNDRSVLENHHAASAWNLFLSQPEHNFLTYLDHVQFKRFRFLVIEAILAT 789

  Fly   983 DMSKHMSLLADLKTMVETKKVAGSGVLLLD--NYTDRIQVLENLVHCADLSNPTKPLPLYKRWVA 1045
            |:.||...||:....|  ..|.|.|:   |  |..||:.|.:..:..||::.|.|...|:.:|..
 Frog   790 DLKKHFDFLAEFNAKV--NDVNGIGI---DWSNENDRLLVCQVCIKLADINGPAKTRELHLKWTE 849

  Fly  1046 LLMEEFFLQGDKERESGMDISPMCDRHNATIEKSQVGFIDYIVHPLWETWADLVHPDAQDILD-- 1108
            .::.||:.|||:|...|:.|||..||....:.|.|..||.:||.||..::      ||..:|.
 Frog   850 GIVNEFYEQGDEESSLGLPISPFMDRSAPQLAKLQESFITHIVGPLCNSY------DAAGLLPGR 908

  Fly  1109 TLEENRDYYQSMIPPSPPPSGVDENPQED---------RIRFQVTLEESDQEN----LAELEEGD 1160
            .|||:.:..:|...........:|..:||         |.|....|....:||    ...:||.:
 Frog   909 WLEEDEEVMESEDEDGEELDSEEEEMEEDINPKPQRRKRRRMFCRLIHHLRENHKAWKKTIEEEE 973

  Fly  1161 ESGGESTTTGTTGTTAA 1177
            :|..|.|...:....||
 Frog   974 KSKAEQTKQQSDDAPAA 990

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDE4_UCR	603..725	CDD:465648	27/132 (20%)
		PDEase_I	870..1110	CDD:459723	95/292 (33%)
pde3b	XP_031756238.1	PDEase_I	636..906	CDD:459723	94/288 (33%)