DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dnc and pde4c

DIOPT Version :9

Sequence 1:	NP_726846.1	Gene:	dnc / 31309	FlyBaseID:	FBgn0000479	Length:	1209	Species:	Drosophila melanogaster
Sequence 2:	XP_004911040.1	Gene:	pde4c / 100380081	XenbaseID:	XB-GENE-1002336	Length:	801	Species:	Xenopus tropicalis

Alignment Length:	734	Identity:	412/734 - (56%)
Similarity:	508/734 - (69%)	Gaps:	82/734 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   475 SASALATSHPSNSQLLP--------TSKMQAEQGSIG------DLQKYH---SRYLKNRRHTLAN 522
            |.||:........||.|        .||.:.|.|.:.      ||..|.   |.||.
Frog    29 SLSAIKRRFSGTPQLPPLYHRQGNDNSKPEPESGRVVFTIEEIDLGTYDDPPSDYLS-------- 85

  Fly   523 VRFDVENG-QGARSPLEG-GSPSAGLVLQ-NLP--QRRESFLYRSDSDFEMSPKSMSRNSSIASE 582
              |||||| ...|||||. .||.:||||| |.|  |||||||||||||:::|||:|||||||||:
Frog    86 --FDVENGLSSGRSPLESQASPGSGLVLQGNFPHSQRRESFLYRSDSDYDLSPKAMSRNSSIASD 148

  Fly   583 RFKEQEASILVDRSHGEDLIVTPFAQILASLRSVRNNLLSLTNVPASNKSRRPNQSSSASRSGNP 647
                         .||||:|||||||:|||||:||:|...||::    :.|..|:.||.  |..|
Frog   149 -------------LHGEDMIVTPFAQVLASLRTVRSNFAMLTHL----QDRVSNKRSSG--SNQP 194

  Fly   648 PGAPLSQGEEAYTRLATDTIEELDWCLDQLETIQTHRSVSDMASLKFKRMLNKELSHFSESSRSG 712
            .....:..|:|..:||.:|:||||||||||||:||..|||:|||.|||||||:||:|.||:||||
Frog   195 SACKPNLSEDAVQKLAIETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSETSRSG 259

  Fly   713 NQISEYICSTFLDKQQEFDLPSLRVEDNPELVAANAAAGQQSAGQYARSRSPRGPPMSQISGVKR 777
            ||:||||.|||||||.|.::|:                      ..::.:..:..|||||||||:
Frog   260 NQVSEYISSTFLDKQHEVEIPT----------------------PVSKEKDKKKRPMSQISGVKK 302

  Fly   778 PLSHTNSFTGERLPTFGVETPRENELGTLLGELDTWGIQIFSIGEFSVNRPLTCVAYTIFQSREL 842
             |:|::||:...:|.|||:|.:|..|...:..::.||:.||.:.|:|.|||||.:.|:|||.|:|
Frog   303 -LTHSSSFSNCSIPRFGVKTEQEVPLAKEVENINKWGLDIFKVAEYSGNRPLTVIMYSIFQERDL 366

  Fly   843 LTSLMIPPKTFLNFMSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFA 907
            |.:..||..||:.:|.||||||..|..:||::|||||.|||:|||:|||||.|||.||:..|:||
Frog   367 LKTFHIPVDTFITYMMTLEDHYHSDVAYHNNIHAADVAQSTHVLLSTPALEAVFTDLEIMAAIFA 431

  Fly   908 ACIHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLR 972
            :.||||||||::||||:|::|||||||||.||||||||||.|||||.:.||||.|:.||||||||
Frog   432 SAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQEENCDIFQNLTKKQRQTLR 496

  Fly   973 KMVIDIVLSTDMSKHMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPL 1037
            |||||:||:|||||||:||||||||||||||...||||||||:||||||:|:|||||||||||||
Frog   497 KMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNMVHCADLSNPTKPL 561

  Fly  1038 PLYKRWVALLMEEFFLQGDKERESGMDISPMCDRHNATIEKSQVGFIDYIVHPLWETWADLVHPD 1102
            .:|::|...::.|||.|||:|||.||:||||||:|||::||||||||||||||||||||||||||
Frog   562 EIYRQWTDRIIVEFFHQGDREREKGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPD 626

  Fly  1103 AQDILDTLEENRDYYQSMIP--PSPPPSGVDE---NPQEDRIRFQVTLE---ESDQENLAELEEG 1159
            ||:||||||:||::||||||  |||||...|.   |...|:.:|::|||   |||.|........
Frog   627 AQEILDTLEDNREWYQSMIPQSPSPPPEEQDPDRGNAAGDKFQFELTLEEEGESDTEQEDTESPI 691

  Fly  1160 DESGGESTTTGTTGTTAAS 1178
            ||...:|....|..:..||
Frog   692 DEENSDSKIHATDDSAQAS 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDEase_I	870..1111	CDD:278654	186/240 (78%)
pde4c	XP_004911040.1	PDEase_I	394..635	CDD:278654	186/240 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	414	1.000	Domainoid score	I665
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	763	1.000	Inparanoid score	I546
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	1	1.000	-	-		otm47870
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X171
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.970