Protein Alignment dnc and pde11a

DIOPT Version :10

• Sequence 1: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Sequence 2: XP_002934646.1
• Gene: pde11a / 100379882
• XenbaseID: XB-GENE-5999893
• Length: 892
• Species: Xenopus tropicalis
• Alignment Length: 1051
• Identity: 201/1051 - (19%)
• Similarity: 355/1051 - (33%)
• Gaps: 328/1051 - (31%)

  Fly   227 PETLSDASVSPTAVVQQQQQQQQQLQQPLLQSQPHFVPSSGNILSQVTLYSGSNPSTNPCQSAVQ 291
            ||...|..:        ::.:.|.:::.:.::|....|||          |.::..:..|.|
 Frog    19 PELFEDYLI--------RKGKHQMVERWMKRNQLAKTPSS----------SSADDKSKDCWS--- 62

  Fly   292 NQGQNSNPNPNQNP-----------NTNPNQNQQRCSCQPQTSPLPHIKEEEESDQANFKHQTSL 345
            |:|.......:|..           |.|...::             |:....:....:.:.:..|
 Frog    63 NRGDGLQRRASQKELRKSFARSKAINVNRTYDE-------------HVNSRAQEPLTSMRRRALL 114

  Fly   346 KEHQPLPPPITIATGYCGSCESVHHSSATSSSAGTVPPGGQQTQEYIAGTSSTPSPRIK-LKFRK 409
            ::...|||            .:.|..||...|...:|       :|       ||..|. :.:.|
 Frog   115 RKASSLPP------------TTAHILSALLESRVNIP-------QY-------PSTAIDYIYYLK 153

  Fly   410 PHKS--------------------CWSRIVLAPIGSAGGSSSATTVIGSNSNETLAS------SS 448
            .|..                    |:..::...|.......|...|.|:.:.::|.|      :.
 Frog   154 EHNERAFFLELVKDISNELNLTSLCYKILIFVCIMVDADRCSLFLVEGTANKKSLVSKFFDVHAG 218

  Fly   449 TTGGTATTTQNSSSVSVAAHHRLTSSSASALATSHPSNSQLLPTSKMQAEQGSIGDLQKYHSRYL 513
            ||...:.:|:||:.|.|                  |....::.......|..:|.|  .|..|..
 Frog   219 TTLLPSCSTENSNEVQV------------------PWGKGIIGYVAEHGETVNIPD--AYQDRRF 263

  Fly   514 KNRRHTLANVRFDVENGQGARSPLEGGSPSAGLVLQNLPQRRESFLYRSDSDFEMSPKSMSRNSS 578
            .:        ..|...|...:|            |..:|.|        .||.|:...:.:.|.:
 Frog   264 SD--------EIDKLTGYKTKS------------LLCMPIR--------SSDGEIIGVAQAINKT 300

  Fly   579 IASERFKEQEASILVDRSHGEDLIVTPFAQILASLRSVRNNLLSLTNVPASNKSRRPNQSSSASR 643
            .....|.|.:..::        .:..||..|            :::|......||:....|
 Frog   301 PGGAPFIEDDEKVM--------QMYLPFCGI------------AISNAQLFAASRKEYDRS---- 341

  Fly   644 SGNPPGAPLSQGEEAYTRLATDTIEELDWCLDQLETIQTHRS-------------VSDMAS--LK 693
                         .|...:..|..|| ...|:::.....||:             :.|:.|  :|
 Frog   342 -------------RALLEVVNDLFEE-QTDLEKVVKKIMHRAQNLLKCERCSVLLLEDIESPVVK 392

  Fly   694 FKR---MLNKELSHFSESSRS-------------GNQISEYICSTFL-----DKQQEFDLPSLRV 737
            |.:   :|:.:.|..:|:|..             .|.|:|.:.||.|     |..|:   |...|
 Frog   393 FTKSFELLSPKCSADTENSFKDSVEKSSYSDWLVNNSIAELVASTGLPVNISDAYQD---PRFDV 454

  Fly   738 EDNPELVAANAAAGQQSAGQYARS--RSPRGPPMSQISGVKRPLSHTNS---------------- 784
            |            ..|.:|.:.||  ..|......||.||.:.|:..:.
 Frog   455 E------------ADQFSGFHIRSVLCVPIWNSSHQIIGVAQVLNRIDGKPFDDADQRLFEAFVI 507

  Fly   785 FTGERLPTFGVETPRENELGTLLGE--LDTWGIQIFSIGEFS---------------VNRPLT-- 830
            |.|     .|:.       .|::.:  ..:|..|..::...|               .|.||.
 Frog   508 FCG-----LGIN-------NTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSE 560

  Fly   831 -----------CV--------AYTIFQSRELLTSLMIPPKTFLNFMSTLEDHYVKDNPFHNSLHA 876
                       |:        |..:|....::....|..:|...::.|:..:| :...:||..||
 Frog   561 LSIADIHFDDFCLDVDAMISAALRMFMELGMVQKFKIDYETLCRWLLTIRKNY-RMVLYHNWRHA 624

  Fly   877 ADVTQSTNVLLNTPALEGVFTPLEVGGALFAACI-HDVDHPGLTNQFLVNSSSELALMYNDESVL 940
            .:|.|....:|.|...:.|.:..|. .||...|: ||:||.|..|.|...|.|.|:.:|...:.|
 Frog   625 FNVCQLMFAMLTTAGFQEVLSDTET-LALIVGCLCHDLDHRGTNNAFQAKSGSALSQLYGTSATL 688

  Fly   941 ENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMVETKKVAG 1005
            |:||...|..:||::|.:||.|:..::...|.:::...:|:||::.|      .:...|..::..
 Frog   689 EHHHFNHAVMILQSEGHNIFANLSSQEYSDLMQLLKQSILATDITLH------FERRNEFFELVN 747

  Fly  1006 SGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKER-ESGMDISPMC 1069
            .|....:..:.|:.....|:...||...|||..:.::...|:..|||.|||:|| |..|..|.:.
 Frog   748 KGDYNWNVKSHRVIFRSMLMTACDLGAATKPWEISRQVAELVTSEFFEQGDRERLELKMTPSAIF 812

  Fly  1070 DRHNA-TIEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEENRDYYQSM------------- 1120
            ||:.. .:.:.|:.:||.|..||:|:... ::...:.:||::..||..::.:
 Frog   813 DRNRKDELPRLQLEWIDNICFPLYESLVK-INGKLKPMLDSVTTNRGKWEELHRKQGNSSSTSYP 876

  Fly  1121 IPPSPPPSGVD 1131
            .|.|.|...::
 Frog   877 TPASSPQPAIE 887

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDE4_UCR	603..725	CDD:465648	28/157 (18%)
		PDEase_I	870..1110	CDD:459723	72/242 (30%)
pde11a	XP_002934646.1	GAF	173..335	CDD:214500	36/229 (16%)
		GAF	357..523	CDD:214500	36/192 (19%)
		PDEase_I	618..853	CDD:459723	72/242 (30%)