Protein Alignment dnc and pde5aa

DIOPT Version :9

• Sequence 1: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Sequence 2: XP_009305135.1
• Gene: pde5aa / 100334568
• ZFINID: ZDB-GENE-100414-2
• Length: 922
• Species: Danio rerio
• Alignment Length: 1145
• Identity: 229/1145 - (20%)
• Similarity: 401/1145 - (35%)
• Gaps: 293/1145 - (25%)

  Fly    60 GGSGSGGGGCGSGSGSGSGKRKSKARTKCFGGTVFR--CCLPCRGGGSAAPATSPPQTPAQTPDE 122
            |.:.|..|..||.|.||..::..:..|:.....:.:  |.:.     |||...:|...|......
Zfish    19 GVASSRRGSQGSRSKSGKKRKSGEKSTRVERNEIEKEQCAIT-----SAAWFFTPLWVPGAKTQR 78

  Fly   123 LKVIPEDCNLEKSAEQKRDLLERNNKEDDLLNRTVSGSELDLYGGAGGGTKKHSLADTIDTSVTT 187
            |     ...:.|.:|:.:..|:   ...|......|.|..:...|..      ..|....|.:|.
Zfish    79 L-----GFRMGKESEKVKAWLD---DYSDSARSYFSRSSRNWMNGCA------ERAQAAQTLITE 129

  Fly   188 PISLKTLINDVDEELDQQLSAADIAAASLASGLVARRAEPETLSDASVSPTAVVQQQQQQQ---- 248
            |.|..|::                          .||.....:|..|.:....|..|:.|.
Zfish   130 PRSKTTVL--------------------------GRRRVSHPMSGPSRALVHPVTMQRPQSCLSV 168

  Fly   249 QQLQQP--LLQSQPHFVPSSGNILSQVTLYSGSNPSTNPCQSAVQNQGQNSNPNPNQNPNTNPNQ 311
            .|...|  |.|...||..|...|          :.:.:||:|..:......:|.|     ....:
Zfish   169 HQTDHPESLDQGGGHFPRSLQPI----------HFTFSPCRSRSRCSSFLGSPRP-----AGQCR 218

  Fly   312 NQQRCSCQPQT-SPLPHIKEEEESDQANFKHQTSLKEHQPLPPPITIATGYCGSC---------E 366
            ..:.|:...|. |.|....:::.......:|...:.|.|.:...:|......|.|         :
Zfish   219 RGESCAFMMQLFSGLIGALQDKNLHLQVLQHLCEVTEAQRVSLSMTTVDKTGGKCLGPVLQSDAD 283

  Fly   367 SVHHSSATSSSAGTVPPGGQQTQEYIAGT-------SSTPSPRIKLKFRKPHKSCWSRIVLAP-- 422
            |||.::.|.        ..:...||:..|       .:...||.:::..:..:...:.::..|
Zfish   284 SVHSNAQTK--------WNKSIMEYVVRTGRPLTVKDAHEDPRFQVELYEGEEDRPTSVLSVPVL 340

  Fly   423 ------IGSAGGSSSATTVIGSNSNETLASSSTTGGTATTTQNSSSVS--------VAAHHRLTS 473
                  ||         .|:..|...|.|||      ..:.|:...:|        :..:|:|..
Zfish   341 NHKKEVIG---------VVLAVNKTRTCASS------FFSEQDEKVLSSHMMLFGLILENHQLCE 390

  Fly   474 SSASALATSHPSNSQLLPTSKMQAEQGSIGDLQKYHSRYLKNRRHTLANVRFDVENGQGARSPLE 538
            ||..    .:..|..||..:::.:                    |...:|  |...|:
Zfish   391 SSEQ----ENKRNQVLLELAQLVS--------------------HDYPSV--DAMLGE------- 422

  Fly   539 GGSPSAGLVLQNLPQRRESF--LYRSDSDFEMSPKSMSRNSSIASERFKEQEASILVDRSHGEDL 601
                   |....||..:..|  ::.||   :.|.:..||...|   .::|.|.|:   .....|.
Zfish   423 -------LAAVILPITKAQFCTVFISD---DSSTRLFSRMVRI---EYEEIECSV---HCSSRDC 471

  Fly   602 IVTPFAQILASLRSVRNNL--LSLTNVPASNKSRRPNQSSSASRSGNPPGAPLSQGEEAYTRLAT 664
            .....:.|.|  ..|:|::  |::.|.|.|..|  |.:|..        |||| :|:::
Zfish   472 DTDDVSYIYA--MHVQNSMETLNIVNRPISMVS--PIRSLI--------GAPL-RGKQS------ 517

  Fly   665 DTIEELDWCLDQLETIQTHRSVSDMASLKFKRMLNKELSHFSESSRSGNQISEYICSTFLDK--- 726
                               .:|..:..|..|||...|...||.:.....:.....|:..|.|
Zfish   518 -------------------SNVIGVCQLVNKRMAIAESEAFSRADEHLLEDFAVYCALGLQKFNT 563

  Fly   727 QQEFDLPSLRVEDNPELVAANAAAGQQSAGQYARSRSPRGPPMSQISGVKRPLSHTNSFTGERLP 791
            ||..|...:|:....|:::...:|.|:...:...:..|
Zfish   564 QQTADKTRVRLAVTKEVLSYQISASQEEINELEEAAIP--------------------------- 601

  Fly   792 TFGVETPRENELGTLLGELDTWGIQIFSIGEFSVNR-PLTCVAYTIFQSRELLTSLMIPPKTFLN 855
                             ..||..:..|...:|.::: .:|.....:|....|.....|..|....
Zfish   602 -----------------SADTLSLLDFGFSDFDMSQNAMTQAVVRMFLDLNLPQEFKIDYKALCQ 649

  Fly   856 FMSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTN 920
            ::.:::..|..:..:||..||....|....:|.|..|:...:.|||...:.|:..||:||.|:.|
Zfish   650 WVLSVQKCYRSNVVYHNWSHALRTAQCMFAMLQTKELKSNLSSLEVLALMIASLSHDLDHRGVNN 714

  Fly   921 QFLVNSSSELALMYNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMS 985
            .::..|:..||.:|. :|.||:||..:...:|.|.|..|..::...:.....:|:...:|:||
Zfish   715 SYIQRSNQPLAQLYG-QSSLEHHHYDMCLLILNNPGSQILSSLSVNEYMACLQMIEKNILATD-- 776

  Fly   986 KHMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEE 1050
              :::..:.:|  :..|:|.:...|..:...|..:...|:..:|:...|||.|:.||...|:..|
Zfish   777 --LAIFFEKRT--KFFKLAENNSCLWKDEGHRELLRSMLMTASDICAITKPWPVQKRIAELVATE 837

  Fly  1051 FFLQGDKERESGMDISP--MCDRHNAT-IEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEE 1112
            |:.|||:|:.. ::|.|  :.||.||: :.:.||.:||.|..||:|..| .:......:.:...:
Zfish   838 FYAQGDREKRE-LNIQPIDVMDRENASRLPQMQVDYIDGICSPLYEALA-FICESCSPLKEGCSK 900

  Fly  1113 NRDYYQSMIPPSPPPSGVDENPQEDRIRFQVTLEESDQEN 1152
            ||.::|.|:          ::.:||.|:        :|||
Zfish   901 NRKHWQEMV----------DDRKEDNIK--------EQEN 922

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDEase_I	870..1111	CDD:278654	70/243 (29%)
pde5aa	XP_009305135.1	GAF	245..388	CDD:214500	27/165 (16%)
		GAF	415..558	CDD:307634	42/205 (20%)
		PDEase_I	664..894	CDD:306695	70/238 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920