Protein Alignment dnc and pde1a

DIOPT Version :10

• Sequence 1: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Sequence 2: NP_001096444.1
• Gene: pde1a / 100125056
• XenbaseID: XB-GENE-949176
• Length: 538
• Species: Xenopus tropicalis
• Alignment Length: 581
• Identity: 176/581 - (30%)
• Similarity: 277/581 - (47%)
• Gaps: 88/581 - (15%)

  Fly   627 PASNKSRRPNQSSSASRSGNPPGAPLSQGEEAYTRLATDTIEELDWCLDQLETIQTHRSVSDMAS 691
            |:||...|.:......|........:.|.|:....: ||....:::....||.:....:
 Frog    14 PSSNFETRESNDKMVQRLQGILRCLVKQLEKGDINV-TDLKNNIEYAASVLEAVYIDET------ 71

  Fly   692 LKFKRMLN--KELSHFSESSRSGNQISEYICSTFLDKQQEFDLPSLRVEDNPEL--VAANAAAGQ 752
               :|:|:  .|||.....| ...::.:::.|||..|   ..:...|.|:.|:.  :.....||.
 Frog    72 ---RRLLDTEDELSDIHTDS-VPLEVRDWLASTFTRK---MGMRKRRPEEKPKFRSIVHAVQAGI 129

  Fly   753 QSAGQYARSRSPRGPPMSQISGVKRPLSHTNSFTGERLPTFGVETPRENELGTLLGELDTWGIQI 817
            .....|.||        |.|:|:..|.|...|                      :.::|.|...:
 Frog   130 FVERMYRRS--------SNIAGLTYPSSVIAS----------------------MKDVDRWAFNV 164

  Fly   818 FSIGEFSVNRPLTCVAYTIFQSRELLTSLMIPPKTFLNFMSTLEDHYVK-DNPFHNSLHAADVTQ 881
            |::.|.|....|..:.|.:|...:|.....||....::|:..||..|.| .||:||.:|||||||
 Frog   165 FTLNEASGEHALKFMVYELFTRYDLTNRFKIPVSNLVSFVEALEVGYSKYKNPYHNLVHAADVTQ 229

  Fly   882 STN-VLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHL 945
            :.: ::|:|..:..: |.||:...:|||.|||.:|.|.||.|.:.:.|::|::|||.|||||||:
 Frog   230 TVHYIILHTGIMHWL-TELEILAMIFAAAIHDFEHTGTTNNFHIQTRSDVAILYNDRSVLENHHV 293

  Fly   946 AVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMVETKKVAGSGVLL 1010
            :.|::::|:...:||.|:.|...:.||.:||::|||||||.|..   .||||..|.: ...|:
 Frog   294 SAAYRIMQDDEMNIFINLSKDDWRDLRTLVIEMVLSTDMSGHFQ---QLKTMRSTLQ-QPEGI-- 352

  Fly  1011 LDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKERESGMDISPMCDRHNAT 1075
                 |:.:.:..::|.||:|:|.||..::.||..|||||||.|||||...|:..||:|||.:..
 Frog   353 -----DKAKAMSLILHAADISHPAKPWDMHLRWTNLLMEEFFRQGDKEAALGLPFSPLCDRKSTM 412

  Fly  1076 IEKSQVGFIDYIVHPLWETWAD----LVHPDAQD-------ILD-TLEENRDYYQSMIPPSPP-- 1126
            :.:||:||||:||.|.:....|    :|.|..::       :.| :.:.|.:..:....|..|
 Frog   413 VAQSQIGFIDFIVEPTFTLLTDSTEKIVFPLIEEAAKSDNSVFDKSSQNNSEVVRGTDTPRKPSV 477

  Fly  1127 -PSGVD-ENPQE------DRIRFQVTLEESDQENLAELEE--GDESGGEST--TTGTTGTT 1175
             .|.:| .:|.|      |...|:..|.|..|:|....:|  ..|...:||  :.|.||.|
 Frog   478 RTSQMDGSSPSEYSLATVDLHHFKKNLVEIIQQNKERWKELAAQERNLKSTHKSEGGTGGT 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDE4_UCR	603..725	CDD:465648	20/99 (20%)
		PDEase_I	870..1110	CDD:459723	102/252 (40%)
pde1a	NP_001096444.1	PDEase_I_N	73..133	CDD:462497	15/63 (24%)
		PDEase_I	218..443	CDD:459723	100/236 (42%)